Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternate splicing results in multiple transcript variants of this gene.[provided by RefSeq, Jun 2012].
Latest Publications for our Thrombopoietin Proteins
McGill, Tomco, Ondrasik, Belknap, Dwyer, Quinlan, Kircher, Andam, Brown, Claxton, Barth: "Therapeutic effect of Northern Labrador tea extracts for acute myeloid leukemia." in: Phytotherapy research : PTR, (2018) (PubMed).
Vas, Wandhoff, Dörr, Niebel, Geiger: "Contribution of an aged microenvironment to aging-associated myeloproliferative disease." in: PLoS ONE, Vol. 7, Issue 2, pp. e31523, (2012) (PubMed).
Kinzfogl, Hangoc, Broxmeyer: "Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells." in: Blood, Vol. 118, Issue 3, pp. 565-75, (2011) (PubMed).