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TRAF3IP2 Products

(TRAF3 Interacting Protein 2 (TRAF3IP2))

Categories

This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq, Aug 2009].

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Featured TRAF3IP2 Categories

TRAF3IP2 Antibodies

High quality antibodies with extensive validation data.

TRAF3IP2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TRAF3IP2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC (p), IF
Validations
  • (5)
Cat. No. ABIN564691
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (5)
Cat. No. ABIN6149464
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IP
Validations
  • (3)
Cat. No. ABIN948987
Quantity 100 μL
Datasheet Datasheet

Recommended TRAF3IP2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1323505
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1323504
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
  • (1)
Cat. No. ABIN3077805
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our TRAF3IP2 products

Das, Carpenter, Yoshida, Kumar, Gautam, Mostany, Izadpanah, Kumar, Mummidi, Siebenlist, Chandrasekar: "TRAF3IP2 mediates TWEAK/TWEAKR-induced pro-fibrotic responses in cultured cardiac fibroblasts and the heart." in: Journal of molecular and cellular cardiology, Vol. 121, pp. 107-123, (2019) (PubMed).

Mummidi, Das, Carpenter, Kandikattu, Krenz, Siebenlist, Valente, Chandrasekar: "Metformin inhibits aldosterone-induced cardiac fibroblast activation, migration and proliferation in vitro, and reverses aldosterone+salt-induced cardiac fibrosis in vivo." in: Journal of molecular and cellular cardiology, Vol. 98, pp. 95-102, (2017) (PubMed).

Sakamuri, Valente, Siddesha, Delafontaine, Siebenlist, Gardner, Bysani: "TRAF3IP2 mediates aldosterone/salt-induced cardiac hypertrophy and fibrosis." in: Molecular and cellular endocrinology, Vol. 429, pp. 84-92, (2016) (PubMed).

Yariswamy, Yoshida, Valente, Kandikattu, Sakamuri, Siddesha, Sukhanov, Saifudeen, Ma, Siebenlist, Gardner, Chandrasekar: "Cardiac-restricted Overexpression of TRAF3 Interacting Protein 2 (TRAF3IP2) Results in Spontaneous Development of Myocardial Hypertrophy, Fibrosis, and Dysfunction." in: The Journal of biological chemistry, Vol. 291, Issue 37, pp. 19425-36, (2016) (PubMed).

Somanna, Yariswamy, Garagliano, Siebenlist, Mummidi, Valente, Chandrasekar: "Aldosterone-induced cardiomyocyte growth, and fibroblast migration and proliferation are mediated by TRAF3IP2." in: Cellular signalling, Vol. 27, Issue 10, pp. 1928-38, (2015) (PubMed).

Valente, Irimpen, Siebenlist, Chandrasekar: "OxLDL induces endothelial dysfunction and death via TRAF3IP2: inhibition by HDL3 and AMPK activators." in: Free radical biology & medicine, Vol. 70, pp. 117-28, (2014) (PubMed).

Valente, Yoshida, Clark, Delafontaine, Siebenlist, Chandrasekar: "Advanced oxidation protein products induce cardiomyocyte death via Nox2/Rac1/superoxide-dependent TRAF3IP2/JNK signaling." in: Free radical biology & medicine, Vol. 60, pp. 125-35, (2013) (PubMed).

Valente, Yoshida, Izadpanah, Delafontaine, Siebenlist, Chandrasekar: "Interleukin-18 enhances IL-18R/Nox1 binding, and mediates TRAF3IP2-dependent smooth muscle cell migration. Inhibition by simvastatin." in: Cellular signalling, Vol. 25, Issue 6, pp. 1447-56, (2013) (PubMed).

Qian, Liu, Hartupee, Altuntas, Gulen, Jane-Wit, Xiao, Lu, Giltiay, Liu, Kordula, Zhang, Vallance, Swaidani, Aronica, Tuohy, Hamilton, Li: "The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease." in: Nature immunology, Vol. 8, Issue 3, pp. 247-56, (2007) (PubMed).

Asao, Okuyama, Kumaki, Ishii, Tsuchiya, Foster, Sugamura: "Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 1, pp. 1-5, (2001) (PubMed).

Synonyms and alternative names related to TRAF3IP2

TRAF3 interacting protein 2 (TRAF3IP2), TRAF3 interacting protein 2 (Traf3ip2), Traf3 interacting protein 2 (Traf3ip2), adapter protein CIKS (LOC100473939), TRAF3 interacting protein 2 L homeolog (traf3ip3.L), TRAF3 interacting protein 2 (traf3ip3), ACT1, Act1, AI429613, C6orf2, C6orf4, C6ORF4, C6orf5, C6orf6, CIKS, MGC134034, PSORS13, RGD1304768, t3jam, traf3ip2, TRAF3IP2

Protein level used designations for TRAF3IP2

  • NFkB-activating protein ACT1
  • adapter protein CIKS
  • connection to IKK and SAPK/JNK
  • nuclear factor NF-kappa-B activator 1
  • TRAF3 interacting protein 2
  • adapter protein CIKS-like
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