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TRIM30 Products

(Tripartite Motif Containing 30 (Trim30))

Categories

Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain. May affect IL2R-alpha expression through cis-acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences. Negatively regulates Toll-like receptor (TLR)-mediated activation of NFKB by promoting degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination. Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex. This, in turn, regulates activation of CASP1 and subsequent cleavage of IL1B and IL18. No activity detected against a range of retroviruses including a number of lentiviruses, gammaretroviruses and betaretroviruses.

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Featured TRIM30 Categories

TRIM30 Antibodies

High quality antibodies with extensive validation data.

Recommended TRIM30 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB
Validations
  • (1)
Cat. No. ABIN342696
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC
Validations
  • (1)
Cat. No. ABIN342695
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Mouse, Rat
Application WB, ELISA, IF, IHC (p)
Validations
Cat. No. ABIN6990956
Quantity 0.1 mg
Datasheet Datasheet

Recommended TRIM30 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3133057
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our TRIM30 products

Tyzack, Hall, Sibley, Cymes, Forostyak, Carlino, Meyer, Schiavo, Zhang, Gibbons, Newcombe, Patani, Lakatos: "A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models." in: Nature communications, Vol. 8, Issue 1, pp. 1164, (2018) (PubMed).

Synonyms and alternative names related to TRIM30

tripartite motif-containing 30 (Trim30), tripartite motif-containing 30A (Trim30a), RGD1563970, Rpt-1, Rpt1, Trim30

Protein level used designations for TRIM30

  • down regulatory protein of interleukin-2 receptor
  • regulatory protein, T lymphocyte 1
  • tripartite motif protein 30
  • tripartite motif-containing 30
  • tripartite motif-containing protein 30
  • tripartite motif-containing protein 30A
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