(Tissue Specific Transplantation Antigen P35B (TSTA3))
Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II. [provided by RefSeq, Jul 2008].
Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, (2003) (PubMed).
Tonetti, Sturla, Bisso, Benatti, De Flora: "Synthesis of GDP-L-fucose by the human FX protein." in: The Journal of biological chemistry, Vol. 271, Issue 44, pp. 27274-9, (1996) (PubMed).
Aliases for TSTA3 Proteins
tissue specific transplantation antigen P35B (TSTA3) Proteins tissue specific transplantation antigen P35B (Tsta3) Proteins tissue specific transplantation antigen P35B (tsta3) Proteins tissue specific transplantation antigen P35B L homeolog (tsta3.L) Proteins AI256181 Proteins FX Proteins Fx Proteins P35B Proteins p35b Proteins SDR4E1 Proteins sdr4e1 Proteins si:dkey-235d18none Proteins TSTA3 Proteins Tstap35b Proteins zgc:101805 Proteins