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WWP1 Products

(WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1))

Categories

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1\; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.

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Featured WWP1 Categories

WWP1 Antibodies

High quality antibodies with extensive validation data.

WWP1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended WWP1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IF, IHC (p), IP, ELISA, WB
Validations
  • (6)
  • (6)
Cat. No. ABIN564794
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ICC, IF, IHC, WB
Validations
  • (2)
Cat. No. ABIN6266055
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application ELISA, IHC, WB
Validations
  • (2)
Cat. No. ABIN7245725
Quantity 200 μL
Datasheet Datasheet

Recommended WWP1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6208453
Quantity 96 tests
Datasheet Datasheet

Recommended WWP1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3096355
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1325405
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7125747
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our WWP1 products

Cho, Yoo, Yoon, Yoon: "β-dystroglycan is regulated by a balance between WWP1-mediated degradation and protection from WWP1 by dystrophin and utrophin." in: Biochimica et biophysica acta. Molecular basis of disease, Vol. 1864, Issue 6 Pt A, pp. 2199-2213, (2018) (PubMed).

Basheer, Harris, Mentrup, Abreha, Thames, Lea, Swing, Copeland, Jenkins, Price, Matesic: "Cardiomyocyte-specific overexpression of the ubiquitin ligase Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis." in: Journal of molecular and cellular cardiology, Vol. 88, pp. 1-13, (2015) (PubMed).

Zuo, Li, Zhang, Lu, Wang, Zhi, He: "MiR-21 suppresses endothelial progenitor cell proliferation by activating the TGFβ signaling pathway via downregulation of WWP1." in: International journal of clinical and experimental pathology, Vol. 8, Issue 1, pp. 414-22, (2015) (PubMed).

Cheng, Cao, Yuan, Li, Tong: "Knockdown of WWP1 inhibits growth and induces apoptosis in hepatoma carcinoma cells through the activation of caspase3 and p53." in: Biochemical and biophysical research communications, Vol. 448, Issue 3, pp. 248-54, (2014) (PubMed).

Chaudhary, Maddika: "WWP2-WWP1 ubiquitin ligase complex coordinated by PPM1G maintains the balance between cellular p73 and ?Np73 levels." in: Molecular and cellular biology, Vol. 34, Issue 19, pp. 3754-64, (2014) (PubMed).

Subik, Shu, Wu, Liang, Hicks, Boyce, Schiffhauer, Chen, Chen, Tang, Xing: "The ubiquitin E3 ligase WWP1 decreases CXCL12-mediated MDA231 breast cancer cell migration and bone metastasis." in: Bone, Vol. 50, Issue 4, pp. 813-23, (2012) (PubMed).

Cao, Xue, Han, Ma, Chen, Tong: "WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) delays cellular senescence by promoting p27(Kip1) degradation in human diploid fibroblasts." in: The Journal of biological chemistry, Vol. 286, Issue 38, pp. 33447-56, (2011) (PubMed).

Peschiaroli, Scialpi, Bernassola, El Sherbini, Melino: "The E3 ubiquitin ligase WWP1 regulates ?Np63-dependent transcription through Lys63 linkages." in: Biochemical and biophysical research communications, Vol. 402, Issue 2, pp. 425-30, (2010) (PubMed).

Edwards, Clowes, Tsang, Connell, Sanderson, Luzio, Reid: "Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5." in: The Biochemical journal, Vol. 423, Issue 1, pp. 31-9, (2009) (PubMed).

Synonyms and alternative names related to WWP1

WW domain containing E3 ubiquitin protein ligase 1 (WWP1), WW domain containing E3 ubiquitin protein ligase 1 (Wwp1), WW domain containing E3 ubiquitin protein ligase 1 (wwp1), 8030445B08Rik, AIP5, aip5, hSDRP1, hsdrp1, SDRP1, Tiul1, tiul1, WWP1

Protein level used designations for WWP1

  • NEDD4-like E3 ubiquitin-protein ligase WWP1
  • Nedd-4-like ubiquitin-protein ligase
  • TGIF-interacting ubiquitin ligase 1
  • WW domain-containing protein 1
  • atrophin-1 interacting protein 5
  • atrophin-1-interacting protein 5
  • WW domain containing E3 ubiquitin protein ligase 1
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