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ATP Citrate Lyase Proteins (ACLY)

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Additionally we are shipping ACLY Antibodies (80) and ACLY Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACLY 47 P53396
ACLY 104112 Q91V92
Rat ACLY ACLY 24159 P16638
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Top ACLY Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 49 to 54 Days
HOST_Baculovirus infected Insect Cells Human His tag 50 μg Log in to see 16 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days

ACLY Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,

Mouse (Murine)

More Proteins for ATP Citrate Lyase (ACLY) Interaction Partners

Human ATP Citrate Lyase (ACLY) interaction partners

  1. ACC1 and ACLY regulate the levels of ETV4 (show ETV4 Proteins) under hypoxia via increased alpha-ketoglutarate. These results reveal that the ACC1/ACLY-alpha-ketoglutarate-ETV4 (show ETV4 Proteins) axis is a novel means by which metabolic states regulate transcriptional output

  2. ACL activity is associated with increased ATP. Activation of this IGF1 (show IGF1 Proteins)/ACL/cardiolipin pathway combines anabolic signaling with induction of mechanisms needed to provide required ATP.

  3. These results suggest that the combined expression of GLUT1 (show SLC2A1 Proteins) and ACLY could be a more valuable prognostic factor than their individual expression in node-negative patients with NSCLC.

  4. Polymorphisms of ATP citrate lyase gene is associated with recurrence in colorectal cancer.

  5. SNP rs9912300 in ACLY gene was significantly associated with response to therapy in hepatocellular carcinoma

  6. The activation of AMPK (show PRKAA1 Proteins) under ACLY knockdown conditions may lead to p53 (show TP53 Proteins) activation, ultimately leading to cellular senescence.

  7. ATP citrate lyase mediates resistance of colorectal cancer cells to SN38.

  8. These data indicate that inhibition of ACLY might affect both fatty acid elongation in ER and FAO in mitochondria, thereby explaining the TG accumulation with altered fatty acid composition.

  9. ACLY inhibition exerts an anticancer effect via increased reactive oxygen species, and p-AMPK (show PRKAA1 Proteins) could be a predictive biomarker for its therapeutic outcome.

  10. Single nucleotide polymorphisms in the ACACA and ACLY genes are associated with a relative change in plasma triglycierides following fish oil supplementation.

Mouse (Murine) ATP Citrate Lyase (ACLY) interaction partners

  1. These data demonstrate that ACLY mediates glucose-dependent de novo lipogenesis in response to LPS (show TLR4 Proteins) signaling and identify a role for ACLY in several phenotypic changes that define plasma cell differentiation

  2. Results suggest a role for DNA methyltransferase 1 (DNMT1 (show DNMT1 Proteins)) in modulating the timing of differentiation and describe a novel ATP-citrate lyase (ACL)-miR (show MLXIP Proteins)-148a-dependent mechanism for regulating DNMT1 (show DNMT1 Proteins) during adipogenesis.

  3. Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets.

  4. Results demonstrate that hepatic ATP-citrate lyase suppression exerts profound effects on triglyceride mobilization as well as fatty acid compositions in the liver, suggesting an important role for ACL (show APOC4 Proteins) in lipid metabolism.

  5. Data suggest that ATP-citrate lyase (ACLY) expression and activity can be suppressed by exogenous lipids and demonstrate a critical role for ACLY in pancreatic beta cell survival.

  6. crucial role of hepatic ATP-citrate lyase in lipid and glucose metabolism

  7. findings suggest that ATP-citrate lyase activity is required to link growth factor-induced increases in nutrient metabolism to the regulation of histone acetylation and gene expression

Pig (Porcine) ATP Citrate Lyase (ACLY) interaction partners

  1. The results of this study indicate that a C/T mutation affects ACL mRNA expression, probably via the activator protein 2 (show TFAP2A Proteins).

ACLY Protein Profile

Protein Summary

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.

Gene names and symbols associated with ATP Citrate Lyase Proteins (ACLY)

  • ATP citrate lyase (ACLY)
  • ATP citrate lyase (acly)
  • ATP citrate lyase (ATPCL)
  • ATP-citrate synthase (AaeL_AAEL004297)
  • citrate synthase, mitochondrial (CpipJ_CPIJ010291)
  • ATP-citrate synthase (Bm1_26245)
  • atp-citrate synthase (ACL)
  • ATP citrate lyase (Acly)
  • ATP citrate lyase a (aclya)
  • A730098H14Rik protein
  • ACL protein
  • acly protein
  • anon-WO0140519.179 protein
  • ATPCL protein
  • AW538652 protein
  • BcDNA:LD21334 protein
  • cb722 protein
  • CG8322 protein
  • Clatp protein
  • dATPCL protein
  • DDBDRAFT_0205389 protein
  • DDBDRAFT_0235360 protein
  • DDB_0205389 protein
  • DDB_0235360 protein
  • DmATPCL protein
  • Dmel\\CG8322 protein
  • l(2)01466 protein
  • l(2)k09217 protein
  • n(2)k09217 protein
  • zgc:92008 protein

Protein level used designations for ATP Citrate Lyase Proteins (ACLY)

ATP citrate lyase , ATP citrate synthase , ATP-citrate synthase-like , ATP-citrate lyase , ATPCL-PD , ATPCL-PE , ATPCL-PF , CG8322-PD , CG8322-PE , CG8322-PF , ATP-citrate synthase , citrate synthase, mitochondrial , atp-citrate synthase , ATP-citrate (pro-S-)-lyase , citrate cleavage enzyme

100053195 Equus caballus
454672 Pan troglodytes
495086 Xenopus laevis
587157 Strongylocentrotus purpuratus
708501 Macaca mulatta
8621508 Dictyostelium discoideum AX4
100405725 Callithrix jacchus
100422779 Felis catus
100439535 Pongo abelii
100467494 Ailuropoda melanoleuca
36760 Drosophila melanogaster
5564509 Aedes aegypti
6042632 Culex quinquefasciatus
6100149 Brugia malayi
7201075 Phaeodactylum tricornutum CCAP 1055/1
47 Homo sapiens
104112 Mus musculus
24159 Rattus norvegicus
100125957 Sus scrofa
511135 Bos taurus
395373 Gallus gallus
607852 Canis lupus familiaris
654404 Ovis aries
436922 Danio rerio
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