ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteins (ABCB1)

The membrane-associated protein encoded by ABCB1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Antibodies (280) and ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ABCB1 5243 P08183
Rat ABCB1 ABCB1 170913  
Mouse ABCB1 ABCB1 18669 P06795
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Top ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 70 to 75 Days
$12,906.52
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Insect cells (Sf9) Human DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$460.85
Details
Yeast REACT_Entamoeba histolytica His tag   500 μg Log in to see 60 to 71 Days
$962.50
Details

ABCB1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,

Top referenced ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteins

  1. Human ABCB1 Protein expressed in Wheat germ - ABIN1305435 : Kamiie, Ohtsuki, Iwase, Ohmine, Katsukura, Yanai, Sekine, Uchida, Ito, Terasaki: Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria. in Pharmaceutical research 2008 (PubMed)

More Proteins for ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Interaction Partners

Cow (Bovine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) interaction partners

  1. P-gp (show ABCB4 Proteins), Bcrp and Mrp1 (show ABCC1 Proteins) are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.

  2. This study has, for the first time, confirmed the expression of ABCB1 in epithelial cells of the bovine rumen.

  3. Bovine blastocysts stimulated by the combined treatment with forskolin, rifampicin, and interferon-alpha to express high levels of ATP-binding cassette subfamily B member 1 displayed better freezing resistance

  4. ABCB1 is expressed in bovine oocytes and embryos.

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) interaction partners

  1. Compared with the sensitive group, both mdr1 mRNA and P-gp (show ABCB4 Proteins) expressions increased in the resistant group

  2. an SNP in ABCB1 (rs2032582: 2677G > T/A) was significantly associated with atorvastatin-induced liver injury (AILI) indicating that the G allele might be a risk factor for AILI in Japanese population

  3. impact of CYP4F2, ABCB1, and GGCX (show GGCX Proteins) polymorphisms on bleeding episodes associated with acenocoumarol in Russian patients with atrial fibrillation

  4. Collectively, the data establish a hitherto unknown liaison among MDR1, BMI1 (show BMI1 Proteins) and TIP60 (show KAT5 Proteins) and provide mechanistic insights into cisplatin-induced MDR1 expression resulting in acquired cross-resistance against paclitaxel, doxorubicin and likely other anticancer drugs.

  5. High ABCB1 expression is associated with hepatocellular carcinoma.

  6. Our data suggest that the C1236T and G2677A/T SNPs in the MDR1 gene are associated with Crohn's disease and the C1236T risk allele with a more severe course of disease in Algerian pediatric patients.

  7. ATPase measurements imply that DCV and Ho are similarly handled by ABCB1, whereas ABCG2 seems to transport DVC more effectively. In addition, we have developed an image-based high content microscopy screening method for simultaneous in situ measurement of the cellular activity and expression of the ABCG2 multidrug transporter

  8. These results show that multidrug resistant leukemia cell microparticle regulation of ABCC1 (show ABCC1 Proteins) in recipient cells is governed by the transfer of both miR (show MLXIP Proteins)-326 and ABCB1 from donor cells

  9. he modulatory effect of acacetin-doxorubicin combination on doxorubicin influx and efflux was mediated through downregulation of MDR1 treansporter in non-small-cell lung carcinoma (NSCLC) cells.

  10. An additional action of osimertinib that directly inhibits the function of ABCB1.

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) interaction partners

  1. Loss of ABCB1 expression is associated with neonatal hyperbilirubinemia.

  2. the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity

  3. Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.

  4. Chrysosplenetin inhibited P-gp (show ABCB4 Proteins) activity and reverse the up-regulated P-gp (show ABCB4 Proteins) and MDR1 (show ABCB4 Proteins) levels induced by artemisinin.

  5. Tamsulosin and tolterodine with P-gp (show ABCB4 Proteins) gene expression and activity in an enantiomer-specific way.

  6. Pgp-coupled ATPase activity kinetics measured with a range of verapamil and digoxin concentrations fit well to a DDI model encompassing non-competitive and competitive inhibition of digoxin by verapamil.

  7. Data show that human transgenic mutant huntingtin (show HTT Proteins) (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1 (show ABCB4 Proteins)) which suggests that MDR1 (show ABCB4 Proteins) might be a potential therapeutic target for Huntington's disease.

  8. In vitro and in vivo downregulation of the ATP binding cassette transporter (show ABCC3 Proteins) B1 by the HMG-CoA reductase (show HMGCR Proteins) inhibitor simvastatin

  9. Efficient chemoprotection of CDD (show CDA Proteins) and MDR1 (show ABCB4 Proteins) transduced hematopoietic 32D as well as primary lin(-) cells was proven in the context of Ara (show FOXC1 Proteins)-C and anthracycline application

  10. These study data have facilitated understanding of the molecular mechanisms of neurotoxicosis in ABCB1-1Delta mutant mice following exposure to various P-gp (show ABCB4 Proteins) substrates.

ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Protein Profile

Protein Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Gene names and symbols associated with ABCB1

  • ATP binding cassette subfamily B member 1 (ABCB1)
  • ATP binding cassette subfamily B member 1 L homeolog (abcb1.L)
  • ATP binding cassette subfamily B member 1A (Abcb1a)
  • ATP binding cassette subfamily B member 1 (Abcb1)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b)
  • ATP-binding cassette, subfamily B (MDR/TAP), member 1B (Abcb1b)
  • malic enzyme complex, mitochondrial (Mod2)
  • ABC20 protein
  • ABCB1 protein
  • Cd243 protein
  • CLCS protein
  • GP170 protein
  • Mdr protein
  • Mdr-1 protein
  • Mdr1 protein
  • Mdr1a protein
  • Mdr1b protein
  • Mod-2 protein
  • Mod-2r protein
  • Mod-2s protein
  • Mod2-r protein
  • Mod2-s protein
  • p-gp protein
  • PGP1 protein
  • Pgy-1 protein
  • Pgy1 protein
  • xemdr protein

Protein level used designations for ABCB1

bovine P-glycoprotein , multidrug resistance protein 1 , multidrug resistance protein , ATP-binding cassette sub-family B member 1 , P-glycoprotein 1 , colchicin sensitivity , doxorubicin resistance , ATP-binding cassette, subfamily B, member 1 , P-glycoprotein , multidrug resistance p-glycoprotein , ATP-binding cassette, sub-family B (MDR/TAP), member 1 , ATP-binding cassette, subfamily B (MDR/TAP), member 1A , multiple drug resistant 1a , P glycoprotein 1 , multidrug resistance protein 1B , ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1B , ATP-binding cassette, subfamily B, member 1B , P-glycoprotein/multidrug resistance 1 , malic enzyme complex, mitochondrial , malic enzyme, mitochondrial regulatory , malic enzyme, mitochondrial structural

GENE ID SPECIES
281585 Bos taurus
397812 Xenopus laevis
463516 Pan troglodytes
5243 Homo sapiens
403879 Canis lupus familiaris
170913 Rattus norvegicus
100682536 Cricetulus griseus
18669 Mus musculus
24646 Rattus norvegicus
110357 Mus musculus
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