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ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteins (ABCB1)

The membrane-associated protein encoded by ABCB1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Antibodies (252) and ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ABCB1 5243 P08183
Rat ABCB1 ABCB1 170913  
Mouse ABCB1 ABCB1 18669 P06795
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Top ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
Yeast REACT_Entamoeba histolytica His tag   500 μg Log in to see 56 to 66 Days
$962.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
$285.71
Details
HOST_Sf-9 Cells Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$460.85
Details

ABCB1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,

Top referenced ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteins

  1. Human ABCB1 Protein expressed in Wheat germ - ABIN1305435 : Kamiie, Ohtsuki, Iwase, Ohmine, Katsukura, Yanai, Sekine, Uchida, Ito, Terasaki: Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria. in Pharmaceutical research 2008 (PubMed)

More Proteins for ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Interaction Partners

Cow (Bovine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) interaction partners

  1. P-gp (show ABCB4 Proteins), Bcrp and Mrp1 (show ABCC1 Proteins) are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.

  2. This study has, for the first time, confirmed the expression of ABCB1 in epithelial cells of the bovine rumen.

  3. Bovine blastocysts stimulated by the combined treatment with forskolin, rifampicin, and interferon-alpha to express high levels of ATP-binding cassette subfamily B member 1 displayed better freezing resistance

  4. ABCB1 is expressed in bovine oocytes and embryos.

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) interaction partners

  1. P-gp transitions through a complete closed conformation to a complete open conformation in the presence of ADP.

  2. Study investigated the effect of MDR1, CYP2D6 (show CYP2D6 Proteins) and CYP2C19 (show CYP2C19 Proteins) gene polymorphisms on prophylactic therapy response in migraine patients, suggested that migraine patients who receive topiramate prophylactic treatment should be assessed for the presence of the MDR1 C3435T polymorphism

  3. The GG and TT genotypes in CYP3A5 (show CYP3A5 Proteins)*3 and ABCB1 C3435T, respectively, were linked with higher TPC (show CCDC6 Proteins).

  4. The study revealed the correlation between ABCB1 DNA promoter methylation with rs1128503 and rs2032582 polymorphisms in malaria and was related to increased expression of ABCB1 protein levels in complicated malaria group when compared to uncomplicated malaria and control groups.

  5. findings suggest that Tetrandrine prevents paclitaxel-induced MDR by inhibiting Pgp (show PGPEP1 Proteins) overexpression through a mechanism that may involve the inhibition of NF-kappaB (show NFKB1 Proteins) signaling in osteosarcoma.

  6. Results find that ABCB1 is a target of miR (show MLXIP Proteins)-9 and reverses the effect of miR (show MLXIP Proteins)-9-mediated chemoresistance in K562 chronic myelogenous leukemia cells.

  7. findings suggest that osimertinib, a clinically-approved third-generation EGFR (show EGFR Proteins) TKI, can reverse ABCB1-mediated MDR, which supports the combination therapy with osimertinib and ABCB1 substrates may potentially be a novel therapeutic stategy in ABCB1-positive drug resistant cancers.

  8. Subcellular distribution of P-gp (show ABCB4 Proteins) and subsequent downregulation by pristimerin contribute to overcoming ABCB1-mediated chemotherapeutic drug resistance. Our findings suggested inducing the decrease of P-gp (show ABCB4 Proteins) membrane protein could be a new promising alternative therapeutic strategy in ABCB1-mediated Multidrug resistance.

  9. Rack1 regulated P-Glycoprotein activity, which was necessary for adriamycin-induced P-Glycoprotein - mediated phosphorylation of Anxa2 and Erk1/2.

  10. we found that the C3435T MDR1 polymorphism does not affect blood levels of cortisol or ACTH (show POMC Proteins) in healthy Japanese males. The effect size at alpha = 0.05 and at power 0.80 in the present sample size was 0.176 Thus, the present study suggests that the C3435T MDR1 polymorphism does not have a great impact on blood levels of cortisol or ACTH (show POMC Proteins).

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) interaction partners

  1. Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.

  2. Chrysosplenetin inhibited P-gp (show ABCB4 Proteins) activity and reverse the up-regulated P-gp (show ABCB4 Proteins) and MDR1 (show ABCB4 Proteins) levels induced by artemisinin.

  3. Tamsulosin and tolterodine with P-gp (show ABCB4 Proteins) gene expression and activity in an enantiomer-specific way.

  4. Pgp-coupled ATPase activity kinetics measured with a range of verapamil and digoxin concentrations fit well to a DDI model encompassing non-competitive and competitive inhibition of digoxin by verapamil.

  5. Data show that human transgenic mutant huntingtin (show HTT Proteins) (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1 (show ABCB4 Proteins)) which suggests that MDR1 (show ABCB4 Proteins) might be a potential therapeutic target for Huntington's disease.

  6. In vitro and in vivo downregulation of the ATP binding cassette transporter (show ABCC3 Proteins) B1 by the HMG-CoA reductase (show HMGCR Proteins) inhibitor simvastatin

  7. Efficient chemoprotection of CDD (show CDA Proteins) and MDR1 (show ABCB4 Proteins) transduced hematopoietic 32D as well as primary lin(-) cells was proven in the context of Ara (show FOXC1 Proteins)-C and anthracycline application

  8. These study data have facilitated understanding of the molecular mechanisms of neurotoxicosis in ABCB1-1Delta mutant mice following exposure to various P-gp (show ABCB4 Proteins) substrates.

  9. Data indicate that the brain penetration of ABT-888 in both Abcb1a/1b-/- and Abcb1a/1b-/-;Abcg2-/- mice was significantly higher than in wild-type mice.

  10. Expression of Abcb1 at the blood-brain and blood-spinal barriers is upregulated by Nrf2 (show NFE2L2 Proteins).

ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Protein Profile

Protein Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Gene names and symbols associated with ABCB1

  • ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1 (abcb1)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1A (Abcb1a)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b)
  • ATP-binding cassette, subfamily B (MDR/TAP), member 1B (Abcb1b)
  • malic enzyme complex, mitochondrial (Mod2)
  • ABC20 protein
  • ABCB1 protein
  • Cd243 protein
  • CLCS protein
  • GP170 protein
  • Mdr protein
  • Mdr-1 protein
  • Mdr1 protein
  • Mdr1a protein
  • Mdr1b protein
  • Mod-2 protein
  • Mod-2r protein
  • Mod-2s protein
  • Mod2-r protein
  • Mod2-s protein
  • p-gp protein
  • PGP1 protein
  • Pgy-1 protein
  • Pgy1 protein
  • xemdr protein

Protein level used designations for ABCB1

bovine P-glycoprotein , multidrug resistance protein 1 , multidrug resistance protein , ATP-binding cassette sub-family B member 1 , P-glycoprotein 1 , colchicin sensitivity , doxorubicin resistance , ATP-binding cassette, subfamily B, member 1 , P-glycoprotein , multidrug resistance p-glycoprotein , ATP-binding cassette, sub-family B (MDR/TAP), member 1 , ATP-binding cassette, subfamily B (MDR/TAP), member 1A , multiple drug resistant 1a , P glycoprotein 1 , multidrug resistance protein 1B , ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1B , ATP-binding cassette, subfamily B, member 1B , P-glycoprotein/multidrug resistance 1 , malic enzyme complex, mitochondrial , malic enzyme, mitochondrial regulatory , malic enzyme, mitochondrial structural

GENE ID SPECIES
281585 Bos taurus
397812 Xenopus laevis
463516 Pan troglodytes
5243 Homo sapiens
403879 Canis lupus familiaris
170913 Rattus norvegicus
100682536 Cricetulus griseus
18669 Mus musculus
24646 Rattus norvegicus
110357 Mus musculus
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