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Acetylcholinesterase Proteins (AChE)

Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. Additionally we are shipping Acetylcholinesterase Antibodies (280) and Acetylcholinesterase Kits (53) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
AChE 43 P22303
AChE 83817 P37136
AChE 11423 P21836
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Top Acetylcholinesterase Proteins at

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Mouse His tag 10 μg Log in to see 16 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
Yeast Cobra His tag   1 mg Log in to see 56 to 66 Days
Yeast REACT_Atlantic Hagfish His tag   1 mg Log in to see 56 to 66 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Mouse His tag   100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Rat His tag   100 μg Log in to see 11 to 13 Days

AChE Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
Rat (Rattus) ,

Mouse (Murine) , ,

Top referenced Acetylcholinesterase Proteins

  1. Mouse (Murine) Acetylcholinesterase Protein expressed in Human Cells - ABIN2007952 : Hillier, Fulton, Fulton, Graves, Pepin, Wagner-McPherson, Layman, Maas, Jaeger, Walker, Wylie, Sekhon, Becker, OLaughlin, Schaller, Fewell, Delehaunty, Miner, Nash, Cordes, Du, Sun, Edwards et al.: The DNA sequence of human chromosome 7. ... in Nature 2003 (PubMed)
    Show all 5 references for ABIN2007952

More Proteins for Acetylcholinesterase (AChE) Interaction Partners

Human Acetylcholinesterase (AChE) interaction partners

  1. Data suggest membranes of erythrocytes of patients with chronic obstructive pulmonary disease exhibit the following changes: increase in acetylcholinesterase; decrease in total ATPases and Na+/K+-ATPases; increase in lipid peroxidation/oxidative stress.

  2. toxicogenetics/genetic association study in population in Turkey: Data suggest SNP in PON1 (show PON1 Proteins) (192Q/R) is associated with susceptibility to organophosphate poisoning; plasma ACHE activities of exposed workers vary w/ PON1 (show PON1 Proteins) genotype: 192RR>192QR>192QQ.

  3. Data suggest cholinesterase (show BCHE Proteins) inhibitors with high potency have proper conformation in active site of ACHE and interact with key residues (Trp84, Phe330 at catalytic anionic site; Trp279 at peripheral anionic site; Gly118, Gly119, Ala201 at oxyanion hole.

  4. Phosphorylated p38 (show CRK Proteins), DNMT1 (show DNMT1 Proteins) and AChE were aberrantly expressed in a subset of hepatocellular carcinoma tumors.

  5. Report acetylcholinesterase kinetics using fluorogenic probe for the investigation of free thiols.

  6. Report reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase.

  7. Case Report: repetitive obidoxime treatment induced increase of red blood cell acetylcholinesterase activity even in a late phase of a severe methamidophos poisoning.

  8. Data show that the 3D-quantitative structure property relationship (QSAR) models are capable of explaining the experimental phenomenon of ligand recognition and binding to acetylcholinesterase (AChE).

  9. PRX (show PRDX6 Proteins)-105 is a plant-derived recombinant version of the human 'read-through' acetylcholinesterase splice variant (AChE-R) which may be used for treatment/prevention of organophosphate poisoning.

  10. Data suggest that natural antisense RNA may play an important role in acetylcholinesterase (AChE) regulation via affecting the epigenetic modification in the AChE promoter region.

Cow (Bovine) Acetylcholinesterase (AChE) interaction partners

  1. To date, AChE and BChE (show BCHE Proteins) are the only proteins known that include polyproline tetramer organizing peptides in their tetrameric structure.

  2. findings show that AChE induces a remarkable aggregation of PrP (show PRNP Proteins) 106-126 with a mechanism similar to that described for amyloid beta protein

  3. In this work, the catalytic activity of acetylcholinesterase (AChE) immobilized on these materials was investigated, using neostigmina as AChE inhibitor.

  4. Results strongly support the role of acetylcholinesterase in triggering amyloidogenesis and the potential therapeutic relevance of peripheral site blocker compounds.

  5. Hydrolysis of acetylthiocoline, o-nitroacetanilide and o-nitrotrifluoroacetanilide by fetal bovine serum acetylcholinesterase

Guinea Pig Acetylcholinesterase (AChE) interaction partners

  1. iNOS (show NOS2 Proteins) and AChE expression increases in spiral ganglia treated with streptomycin. Salvia miltiorrhiza injection reduces ototoxicity by reducing the levels of iNOS (show NOS2 Proteins) and AChE.

Mouse (Murine) Acetylcholinesterase (AChE) interaction partners

  1. Nerolidol-loaded nanospheres reverse memory impairment and to prevent increased ROS (show ROS1 Proteins) and TBARS levels due to amelioration of Na(+), K(+)-ATPase (show ATP1A1 Proteins) and AChE activities and to activation of the antioxidant enzymes, respectively.

  2. the amounts of AChE activity, AChE catalytic subunit, structure subunit PRiMA (show PRIMA1 Proteins) and the amount of acetylcholine, in the brain were not, significantly, altered, suggesting the role of P2Y1R in neuron could have different function as that in muscle.

  3. In P2Y1R (-/-) mice, acetylcholinesterase expression in muscle was markedly decreased. The proline-rich membrane anchor subunit was reduced by 60 %; while the collagen tail subunit was reduced by 50 %. AChE molecular forms in the muscle were not changed.

  4. Reduction of AChE levels in prion (show PRNP Proteins)-infected heterozygous AChE knock-out mice leads to slightly but significantly prolonged incubation time.

  5. mRNA expressions of brain specific (show CALY Proteins) fatty acid protein 7 (fabp-7 (show FABP7 Proteins)) and phospholipase A2 (show YWHAZ Proteins) group IV (pla2g4 (show PLA2G4A Proteins)) were significantly downregulated in AChE-deficient mice.

  6. AChE is regulated in two neuronal cell lines by APP (show APP Proteins) in a manner independent of the generation of sAPPalpha, sAPPbeta, and AICD.

  7. Deficiency or inhibition of acetylcholinesterase can decrease apoptosis and protect dopaminergic neurons in the neurotoxin model of Parkinson's disease.

  8. Attribute stress-inducible cognitive impairments to cholinergic-mediated induction of miR (show MLXIP Proteins)-132 and consequently suppressed synaptic ACHE.

  9. assayed the relative activities of AChE and BChE (show BCHE Proteins) in membrane fractions and culture medium of three different neuronal cell lines, namely the neuroblastoma (show ARHGEF16 Proteins) cell lines SH-SY5Y and NB7 and the basal forebrain cell line SN56

  10. Long-lasting stress-inducible changes in AChE's promoter choices, identify the chromatin changes that support this long-term transcriptional memory, and reveal HDAC4 (show HDAC5 Proteins) as a mediator of these effects in the hippocampus.

Zebrafish Acetylcholinesterase (AChE) interaction partners

  1. Findings provide evidence that brain acetylcholinesterase (AChE) is a potential target for microcystins (MCs (show MOCOS Proteins)).

  2. aryl acylamidase associated with acetylcholinesterase was higher than the esterase (show ESD Proteins) activity on zebrafishembryo

Pig (Porcine) Acetylcholinesterase (AChE) interaction partners

  1. Compared potency of oxime antidotes to reactivate pig brain acetylcholinesterase (AChE) after sarin exposure.

Acetylcholinesterase (AChE) Protein Profile

Protein Summary

Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally.

Gene names and symbols associated with Acetylcholinesterase Proteins (AChE)

  • acetylcholinesterase 2 (AChE-2)
  • acetylcholinesterase (ACHE)
  • Acetylcholine esterase (Dsim\\Ace)
  • acetylcholinesterase (Ache)
  • acetylcholinesterase (ache)
  • acetylcholinesterase (ACE-1)
  • acetylcholinesterase-like (LOC100621099)
  • ACE protein
  • ACE2 protein
  • ACEE protein
  • ache protein
  • ARACHE protein
  • Dsim\\GD20515 protein
  • dsim_GLEANR_4292 protein
  • GB14873 protein
  • GD20515 protein
  • mE1a protein
  • mE1b protein
  • mE1c protein
  • mE1c-long protein
  • mE1d protein
  • mE1d' protein
  • mE1e protein
  • N-ACHE protein
  • YT protein
  • zgc:92550 protein

Protein level used designations for Acetylcholinesterase Proteins (AChE)

acetylcholinesterase (Yt blood group) , acetylcholinesterase isoform E4-E6 , Ace-PA , Dsim\\Ace-PA , Dsim\\GD20515-PA , GD20515-PA , acetylcholine esterase , acetylcholinesterase , Yt blood group , apoptosis-related acetylcholinesterase , glycolipid-anchored form of acetylcholinesterase , ziehharmonika , zim

406104 Apis mellifera
463612 Pan troglodytes
713370 Macaca mulatta
6728249 Drosophila simulans
100135759 Tribolium castaneum
100158421 Xenopus laevis
100169895 Ciona intestinalis
100579679 Nomascus leucogenys
100609296 Pan troglodytes
43 Homo sapiens
540446 Bos taurus
493674 Felis catus
100009390 Oryctolagus cuniculus
83817 Rattus norvegicus
100422792 Cavia porcellus
11423 Mus musculus
489828 Canis lupus familiaris
396388 Gallus gallus
101123006 Ovis aries
114549 Danio rerio
100621099 Sus scrofa
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