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Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (By similarity). Additionally we are shipping Aconitase 1 Antibodies (74) and Aconitase 1 Kits (8) and many more products for this protein.
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The Irp1-/- mice develop polycythemia and pulmonary hypertension, and suggesting that Irp1 plays an essential role in erythropoiesis and in the pulmonary and cardiovascular systems.
IRP1 and IRP2 (show IREB2 Proteins) mutant mice rapidly succumb to systemic infection with Salmonella Typhimurium, a pathogenic bacterium that multiplies within macrophages, with increased bacterial burdens in liver and spleen.
results uncover an unexpected protective role of IRP1 in pathological conditions associated with altered Fe-S metabolism
Aco1 KD in fully differentiated 3T3-L1 adipocytes decreased lipogenic, Idh1 (show IDH1 Proteins), Adipoq (show ADIPOQ Proteins), and Glut4 (show SLC2A4 Proteins) gene expression.
impaired mitochondrial [Fe-S] cluster biogenesis in Mfrn1(gt/gt (show FABP6 Proteins)) cells results in elevated IRP1 RNA-binding that attenuates ALAS2 (show ALAS2 Proteins) mRNA translation and protoporphyrin accumulation
Data indicate that JTR-009, a benzimidazole, operated by preventing iron-regulatory protein-1 (IRP1) from binding to the iron-responsive element (IRE) in APP (show APP Proteins) mRNA.
Human ACO1 is a moonlighting protein that has both aconitase (show ACO2 Proteins) enzyme activity as well as an mRNA binding function.
Aco1 is a moonlighting protein that has aconitase (show ACO2 Proteins) activity as well as mRNA binding ability.
IRP1 is the principal regulator of HIF2alpha (show EPAS1 Proteins) mRNA translation
Irp1 deletion enhanced HIF2alpha (show EPAS1 Proteins) protein expression in kidneys of Irp1(-/-) mice.
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (By similarity). Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding (By similarity).
, citrate hydro-lyase
, cytoplasmic aconitase
, cytoplasmic aconitate hydratase
, iron regulatory protein 1
, iron-responsive element-binding protein 1