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Aconitase 2, Mitochondrial Proteins (ACO2)

The protein encoded by ACO2 belongs to the aconitase/IPM isomerase family. Additionally we are shipping ACO2 Antibodies (102) and ACO2 Kits (34) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACO2 50 Q99798
ACO2 11429 Q99KI0
ACO2 79250 Q9ER34
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Top ACO2 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag,GST tag 10 μg Log in to see 16 Days
$272.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Baculovirus infected Insect Cells Mouse His tag,GST tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,203.83
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ACO2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus)

Top referenced ACO2 Proteins

  1. Human ACO2 Protein expressed in Baculovirus infected Insect Cells - ABIN2003654 : Lauble, Kennedy, Beinert, Stout: Crystal structures of aconitase with isocitrate and nitroisocitrate bound. in Biochemistry 1992 (PubMed)

More Proteins for Aconitase 2, Mitochondrial (ACO2) Interaction Partners

Arabidopsis thaliana Aconitase 2, Mitochondrial (ACO2) interaction partners

  1. The identification of ACO1 (show ACO1 Proteins), ACO2, and ACO3 in A. thaliana is reported, and it was demonstrated that, in plants, the cytosolic ACOs are not converted into iron regulatory proteins.

Human Aconitase 2, Mitochondrial (ACO2) interaction partners

  1. Results suggest that ACO2 activity is reduced in peripheral lymphocytes of subjects with Alzheimer's disease and mild cognitive impairment and correlates with antioxidant protection

  2. Our study shows that autosomal recessive ACO2 mutations can cause either isolated or syndromic optic neuropathy.

  3. immunofluorescence staining localized ACO2 to the human sperm mid-piece. By immunoblotting, we demonstrated that the level of ACO2 protein in asthenozoospermic samples was significantly decreased compared with that in normal fertile men

  4. Ogg1 (show OGG1 Proteins) chaperoning of Aco-2 in preventing oxidant-mediated mtDNA damage and apoptosis may afford an innovative target for the molecular events underlying oxidant-induced toxicity.

  5. Hypoxia upregulates the gene expression of mitochondrial aconitase in prostate carcinoma cells

  6. Gastric cancer patients with lower ACO2 expression have a shorter survival time than those with higher ACO2 expression.

  7. Homozygosity mapping followed by whole-exome sequencing disclosed a Ser112Arg mutation in ACO2.

  8. these results suggest that p53 downregulation of mACON gene expression in human prostate carcinoma cells may not occur through the putative consensus p53 response elements found within the mACON promoter.

  9. Lon (show LONP1 Proteins) protease selectively recognizes and degrades the oxidized, hydrophobic form of aconitase (show ACO1 Proteins) after mild oxidative modification, but that severe oxidation results in aconitase (show ACO1 Proteins) aggregation, which makes it a poor substrate for Lon (show LONP1 Proteins).

  10. ACO2 is often deleted in colorectal cancer (show DCC Proteins) but is unlikely to be the true target of the deletions

Mouse (Murine) Aconitase 2, Mitochondrial (ACO2) interaction partners

  1. Activation of mitochondrial aconitase is acetylation-dependent.

  2. Ogg1 (show OGG1 Proteins) chaperoning of Aco-2 in preventing oxidant-mediated mtDNA damage and apoptosis may afford an innovative target for the molecular events underlying oxidant-induced toxicity.

  3. IRP-1 (show ACO1 Proteins),-2 are indispensable for regulation of mammalian iron homeostasis at the post-implantation stage of murine embryonic development

  4. aconitase activity can be regulated by at least two mechanisms: oxidation/reduction and phosphorylation/dephosphorylation

Pig (Porcine) Aconitase 2, Mitochondrial (ACO2) interaction partners

  1. study examined the sites and mechanisms of aconitase inactivation by peroxynitrite (ONOO-), a strong oxidant and nitrating agent readily formed from superoxide anion and nitric oxide generated by mitochondria

ACO2 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification.

Gene names and symbols associated with ACO2

  • aconitase 2, mitochondrial (ACO2)
  • aconitase 2, mitochondrial (aco2)
  • aconitate hydratase, mitochondrial (Bm1_07420)
  • aconitase, mitochondrial (aco2)
  • mitochondrial aconitate hydratase (ach1)
  • aconitase 2 (ACO2)
  • aconitase 2, mitochondrial (LOC100352714)
  • aconitase 2, mitochondrial (Aco2)
  • Protein ACO-2 (aco-2)
  • Aco-2 protein
  • Aco3 protein
  • aconitase 2 protein
  • ACONM protein
  • cb1017 protein
  • D10Wsu183e protein
  • DDBDRAFT_0206187 protein
  • DDBDRAFT_0230168 protein
  • DDB_0206187 protein
  • DDB_0230168 protein
  • F10M23.310 protein
  • F10M23_310 protein
  • ICRD protein
  • wu:fa10e03 protein
  • wu:fb69g04 protein
  • wu:fc20c11 protein

Protein level used designations for ACO2

aconitate hydratase, mitochondrial , mitochondrial aconitate hydratase , aconitase 2, mitochondrial , aconitate hydratase, mitochondrial-like , citrate hydro-lyase , mitochondrial aconitase (nuclear aco2 gene) , heart aconitase

GENE ID SPECIES
374009 Gallus gallus
444692 Xenopus laevis
6096411 Brugia malayi
8621690 Dictyostelium discoideum AX4
9617127 Volvox carteri f. nagariensis
100444223 Pongo abelii
496933 Xenopus (Silurana) tropicalis
707441 Macaca mulatta
828805 Arabidopsis thaliana
100352714 Oryctolagus cuniculus
100389367 Callithrix jacchus
100568244 Anolis carolinensis
100598337 Nomascus leucogenys
50 Homo sapiens
11429 Mus musculus
79250 Rattus norvegicus
396999 Sus scrofa
280976 Bos taurus
474487 Canis lupus familiaris
322670 Danio rerio
176121 Caenorhabditis elegans
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