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anti-Actinin, alpha 4 (ACTN4) Antibodies

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Additionally we are shipping alpha Actinin 4 Kits (15) and alpha Actinin 4 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ACTN4 60595 P57780
ACTN4 63836 Q9QXQ0
ACTN4 81 O43707
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Top anti-alpha Actinin 4 Antibodies at antibodies-online.com

Showing 10 out of 88 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-ACTN4 Antibody Titration: 0.2-1 ug/mlPositive Contro... WB Suggested Anti-ACTN4  Antibody Titration: 0.2-1 µg/mL  Positive Con... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-ACTN4 Antibody (N-term) (ABIN392218) in ... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-ACTN4 Antibody Titration: 0.625ug/mlPositive Control... WB Suggested Anti-ACTN4  Antibody Titration: 0.625 µg/mL  Positive Con... 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of ACTN4 Antibody (C-term) (ABIN392219) in T47D,... Formalin-fixed and paraffin-embedded human breast carcinoma reacted wi... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to ACTN4 on HeLa cell (antib... 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 100 μL Log in to see 5 to 6 Days
$320.60
Details
Human Rabbit Un-conjugated EIA, IHC (fro), WB 0.1 mg Log in to see 6 to 8 Days
$555.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image alpha Actinin 4 antibody [C2C3], C-term detects ACTN4 protein... IHC-P Image alpha Actinin 4 antibody [C2C3], C-term detects alpha Acti... 100 μL Log in to see 2 to 3 Days
$358.60
Details

ACTN4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine) , , , ,
,
Rat (Rattus) , , , ,
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Human , , , ,
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Top referenced anti-alpha Actinin 4 Antibodies

  1. Human Monoclonal alpha Actinin 4 Primary Antibody for IF, WB - ABIN396311 : Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010 (PubMed)
    Show all 5 references for ABIN396311

  2. Chicken Polyclonal alpha Actinin 4 Primary Antibody for IHC, WB - ABIN2775288 : Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. in Diagnostic microbiology and infectious disease 2006 (PubMed)
    Show all 3 references for ABIN2775288

  3. Human Polyclonal alpha Actinin 4 Primary Antibody for EIA, IHC (p) - ABIN360099 : Kikuchi, Honda, Tsuda, Hiraoka, Imoto, Kosuge, Umaki, Onozato, Shitashige, Yamaguchi, Ono, Tsuchida, Aoki, Inazawa, Hirohashi, Yamada: Expression and gene amplification of actinin-4 in invasive ductal carcinoma of the pancreas. in Clinical cancer research : an official journal of the American Association for Cancer Research 2008 (PubMed)
    Show all 3 references for ABIN360099

  4. Human Polyclonal alpha Actinin 4 Primary Antibody for EIA, WB - ABIN360100 : Barbolina, Adley, Kelly, Fought, Scholtens, Shea, Stack: Motility-related actinin alpha-4 is associated with advanced and metastatic ovarian carcinoma. in Laboratory investigation; a journal of technical methods and pathology 2008 (PubMed)
    Show all 3 references for ABIN360100

  5. Chicken Polyclonal alpha Actinin 4 Primary Antibody for WB - ABIN2775289 : Kimura, Wakamatsu, Suzuki, Ota, Nishikawa, Yamashita, Yamamoto, Sekine, Tsuritani, Wakaguri, Ishii, Sugiyama, Saito, Isono, Irie, Kushida, Yoneyama, Otsuka, Kanda, Yokoi, Kondo, Wagatsuma, Murakawa et al.: Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. ... in Genome research 2006 (PubMed)
    Show all 2 references for ABIN2775289

  6. Human Monoclonal alpha Actinin 4 Primary Antibody for IF, IHC (p) - ABIN559759 : Yamada, Yanamoto, Yoshida, Yoshitomi, Kawasaki, Mizuno, Nemoto: RNAi-mediated down-regulation of alpha-actinin-4 decreases invasion potential in oral squamous cell carcinoma. in International journal of oral and maxillofacial surgery 2010 (PubMed)

  7. Human Polyclonal alpha Actinin 4 Primary Antibody for EIA, IHC (fro) - ABIN1105323 : Celli, Ryckewaert, Delachanal, Duperray: Evidence of a functional role for interaction between ICAM-1 and nonmuscle alpha-actinins in leukocyte diapedesis. in Journal of immunology (Baltimore, Md. : 1950) 2006 (PubMed)

More Antibodies against alpha Actinin 4 Interaction Partners

Mouse (Murine) Actinin, alpha 4 (ACTN4) interaction partners

  1. ACTN4 is a transcriptional coactivator of NF-kappaB (show NFKB1 Antibodies).

  2. UCHL1 (show UCHL1 Antibodies) upregulation in ACTN4-associated FSGS.

  3. sLZIP negatively regulates skeletal muscle differentiation via interaction with ACTN4.

  4. the C-terminal tail of alpha-actinin-4 is essential for its function in cell migration and adhesion to substratum.

  5. Dexamethasone mey protect actin cytoskeleton stabilization from adriamycin-induced podocyte injury via alpha-actinin-4.

  6. anti-dsDNA Fab (show FANCB Antibodies) may enhance F-actin formation by the proprietary modification of alpha-actinin-4

  7. Together, these results indicate that alpha-actinin (show ACTN1 Antibodies) and the actin cytoskeleton are important components of the cisternal organelle that are probably required to stabilize the AIS (show AR Antibodies).

  8. Results suggest that ACTN4 is essential for maintaining normal spreading, motility, cellular and nuclear cross-sectional area, and contractility of lung fibroblasts by maintaining the balance between transcellular contractility and cell-adhesion.

  9. newly developed mouse model of ACTN4-associated FSGS suggests a cause-and-effect relationship between actin cytoskeleton dysregulation by mutant alpha-actinin-4 and the deterioration of the nephrin (show NPHS1 Antibodies)-supported slit diaphragm complex.

  10. nonsarcomeric alpha-actinin-4 is involved in the regulation of cell movement

Human Actinin, alpha 4 (ACTN4) interaction partners

  1. This study identified alpha-actinin-4 as a novel NHERF1 (show SLC9A3R1 Antibodies) interaction partner and provided new insights into the regulatory mechanism of the actin cytoskeleton by NHERF1 (show SLC9A3R1 Antibodies).

  2. Selective regulation of NF-kappaB (show NFKB1 Antibodies) gene targets may indicate involvement of ACTN4 in determining the specificity of cell response to NF-kappaB (show NFKB1 Antibodies) activation in cells of different types. (Review)

  3. ZYX (show ZYX Antibodies) defective binding to ACTN4, which occupies focal adhesions instead of ACTN1 (show ACTN1 Antibodies), induces the formation of immature focal adhesions, resulting in the enhancement of cell motility and invasion.

  4. The contribution of ACTN4 to the process of lung cancer metastasis to the brain could be mainly through regulation of actin cytoskeleton reorganization, cell motility, and focal adhesion.

  5. SLK (show FYN Antibodies) interacts with Tpr and alpha-actinin-4 in cells, and these protein-protein interactions may control the subcellular localization and the biological activity of SLK (show FYN Antibodies).

  6. key regulator of endothelial cell stiffness and of ICAM-1 (show ICAM1 Antibodies)-mediated neutrophil transmigration

  7. Knockdown of ACTN4 protein inhibited cell invasion and migration. These results suggest that ACTN4 is associated with lung cancer cell motility.

  8. alpha-actinin-4 is a novel group 1 mGluR (show GRM8 Antibodies)-interacting partner that orchestrates spine dynamics and morphogenesis in neurons.

  9. Using fluorescence recovery after photobleaching, we show that an ACTN4 mutation that causes human kidney disease roughly triples the wild-type binding affinity of ACTN4 to F-actin in cells, increasing the dissociation time from 29 +/- 13 to 86 +/- 29 s.

  10. Estrogen promotes the invasion of ovarian cancer cells via activation of the PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) pathway, downregulation of Ecadherin and upregulation of alphaactinin4.

alpha Actinin 4 (ACTN4) Antigen Profile

Protein Summary

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.

Gene names and symbols associated with ACTN4

  • actinin, alpha 4 (actn4) antibody
  • actinin, alpha 4 (ACTN4) antibody
  • actinin alpha 4 (Actn4) antibody
  • ACTININ-4 antibody
  • C77391 antibody
  • FSGS antibody
  • FSGS1 antibody
  • wu:fb53f05 antibody
  • zgc:63508 antibody

Protein level used designations for ACTN4

actinin, alpha 4 , alpha-actinin-4-like , F-actin cross-linking protein , alpha-actinin-4 , non-muscle alpha-actinin 4 , alpha actinin 4 , actinin alpha4 isoform , focal segmental glomerulosclerosis 1 , alpha-actinin

GENE ID SPECIES
448522 Xenopus (Silurana) tropicalis
100392168 Callithrix jacchus
100588862 Nomascus leucogenys
60595 Mus musculus
63836 Rattus norvegicus
81 Homo sapiens
322221 Danio rerio
446865 Xenopus laevis
396024 Gallus gallus
484526 Canis lupus familiaris
522269 Bos taurus
100174343 Pongo abelii
Selected quality suppliers for anti-alpha Actinin 4 (ACTN4) Antibodies
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