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Activated Leukocyte Cell Adhesion Molecule Proteins (ALCAM)

ALCAM encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. Additionally we are shipping CD166 Antibodies (177) and CD166 Kits (62) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ALCAM 214 Q13740
ALCAM 11658 Q61490
ALCAM 79559 O35112
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Top CD166 Proteins at antibodies-online.com

Showing 10 out of 37 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 200 μg Log in to see 2 to 3 Days
$275.00
Details
HOST_HEK-293 Cells Human Fc Tag 200 μg Log in to see 2 to 3 Days
$297.00
Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$272.80
Details
HOST_Human Cells Cynomolgus His tag 100 μg Log in to see 16 Days
$272.80
Details
HOST_Human Cells Rat Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Cynomolgus Fc Tag 100 μg Log in to see 16 Days
$250.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details

ALCAM Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
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Mouse (Murine) , , ,
, , , ,
Rat (Rattus) , ,
,

Top referenced CD166 Proteins

  1. Mouse (Murine) CD166 Protein expressed in Human Cells - ABIN2007131 : Bowen, Patel, Li, Modrell, Malacko, Wang, Marquardt, Neubauer, Pesando, Francke: Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. in The Journal of experimental medicine 1995 (PubMed)
    Show all 5 references for ABIN2007131

  2. Cynomolgus CD166 Protein expressed in Human Cells - ABIN2010018 : Aruffo, Bowen, Patel, Haynes, Starling, Gebe, Bajorath: CD6-ligand interactions: a paradigm for SRCR domain function? in Immunology today 1998 (PubMed)
    Show all 4 references for ABIN2010018

  3. Human CD166 Protein expressed in Human Cells - ABIN2001959 : Degen, van Kempen, Gijzen, van Groningen, van Kooyk, Bloemers, Swart: MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule). in The American journal of pathology 1998 (PubMed)
    Show all 4 references for ABIN2001959

  4. Rat (Rattus) CD166 Protein expressed in Human Cells - ABIN2009330 : van Kempen, Nelissen, Degen, Torensma, Weidle, Bloemers, Figdor, Swart: Molecular basis for the homophilic activated leukocyte cell adhesion molecule (ALCAM)-ALCAM interaction. in The Journal of biological chemistry 2001 (PubMed)
    Show all 4 references for ABIN2009330

  5. Human CD166 Protein expressed in HEK-293 Cells - ABIN2180701 : Skonier, Bowen, Emswiler, Aruffo, Bajorath: Recognition of diverse proteins by members of the immunoglobulin superfamily: delineation of the receptor binding site in the human CD6 ligand ALCAM. in Biochemistry 1996 (PubMed)
    Show all 2 references for ABIN2180701

  6. Human CD166 Protein expressed in HEK-293 Cells - ABIN2180703 : Bajorath, Bowen, Aruffo: Molecular model of the N-terminal receptor-binding domain of the human CD6 ligand ALCAM. in Protein science : a publication of the Protein Society 1996 (PubMed)
    Show all 2 references for ABIN2180703

More Proteins for Activated Leukocyte Cell Adhesion Molecule (ALCAM) Interaction Partners

Zebrafish Activated Leukocyte Cell Adhesion Molecule (ALCAM) interaction partners

  1. Alcama mediates Edn1 (show EDN1 Proteins) signaling during zebrafish cartilage morphogenesis.

Xenopus laevis Activated Leukocyte Cell Adhesion Molecule (ALCAM) interaction partners

  1. The cell-adhesion molecule (show MCAM Proteins) Alcam is required for proper nephrogenesis and functions downstream of Fzd3 (show FZD3 Proteins) during embryonic kidney development.

Atlantic Salmon (Salmo salar) Activated Leukocyte Cell Adhesion Molecule (ALCAM) interaction partners

  1. No significant association between ALCAM expression and survival data was observed for all tumors

Human Activated Leukocyte Cell Adhesion Molecule (ALCAM) interaction partners

  1. Prognostic Significance of CD44v6, CD133, CD166, and ALDH1 (show ALDH1A1 Proteins) Expression in Small Intestinal Adenocarcinoma.

  2. The binding sites on CD6 (show CD6 Proteins) and CD166 have been characterized to show that a SNP in CD6 (show CD6 Proteins) causes glycosylation that hinders the CD6 (show CD6 Proteins)/CD166 interaction.

  3. a model that CD166 regulates MCAM (show MCAM Proteins) through a signaling flow from activation of PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) and c-Raf (show RAF1 Proteins)/MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins) signaling to the inhibition of potential MCAM (show MCAM Proteins) ubiquitin E3 ligases, betaTrCP (show BTRC Proteins) and Smurf1 (show SMURF1 Proteins)

  4. High ALCAM expression in melanoma cells of the primary tumor may indicate a more invasive phenotype. Low expression of ALCAM in regional lymph node metastases is a feature associated with unfavorable prognosis in patients with cutaneous melanoma.

  5. High ALCAM expression is associated with Invasive Cholangiocarcinoma.

  6. The Serum CD166 is a novel diagnostic tumor marker for hepatocellular carcinoma (HCC (show FAM126A Proteins)).

  7. Overexpression of activated leukocute cell adhesion molecule (show MCAM Proteins) in gastric cancer is associated with advanced stages and poor prognosis and miR (show MLXIP Proteins)-9 deregulation

  8. Differentially expressed/regulated cancer-related genes upon miR (show MLXIP Proteins)-125b expression along with the significant increase of ALCAM

  9. Low expression of ALCAM at sites of cell-cell contact in primary breast cancer tumors regardless of differentiation, size and lymph node involvement may contribute to the more aggressive phenotype of breast cancer among African-American women.

  10. an overexpression of CD166 was detected in the benign and malignant salivary gland tumors and its expression in the malignant tumor was associated with the aggressive behavior and tumor progression.

Mouse (Murine) Activated Leukocyte Cell Adhesion Molecule (ALCAM) interaction partners

  1. Our results indicate that the loss of CD166 impacts hematopoietic stem cell numbers

  2. Data indicate that the CD166/AKT (show AKT1 Proteins) axis modulates tumorigenesis via promotion of phosphorylation and facilitation of degradation, ubiquitination and cytosolic accumulation of FOXO (show FOXO3 Proteins) proteins in liver cancer cells.

  3. ALCAM stably interacts with actin by binding to syntenin-1 (show SDCBP Proteins) and ezrin (show EZR Proteins).

  4. CD166/ALCAM (ALCAM) is a close structural and functional homolog of RAGE (show AGER Proteins); it shows that binding of S100B (show S100B Proteins) to CD166/ALCAM induces dose- and time-dependent expression of NF-kappaB (show NFKB1 Proteins) family members in wild type and RAGE (show AGER Proteins)-deficient mouse endothelial cells.

  5. Activated Leukocyte Cell Adhesion Molecule (ALCAM) or CD166 expression on osteoblasts is directly correlated with Runx2 (show RUNX2 Proteins) expression and high hematopoiesis enhancing activity.

  6. Behavioral deficits caused by prolonged IFN alpha (show IFNA Proteins) treatment were not prevented by blocking ALCAM, which is involved in immune cell entry to the brain.

  7. novel role for ALCAM in stabilizing LEC-LEC interactions and in the organization and function of the LV network.

  8. The presence of CD166 on prostate stem/progenitors and castration resistant sub-populations suggest that it is a cell surface molecule with the potential for targeted delivery of human prostate cancer therapeutics.

  9. CD166 is highly expressed within the endogenous intestinal stem cell niche

  10. The higher adhesion molecules expression and higher BBB permeability contributed to the major inflammatory cell infiltration into the CNS of C57BL/6 mice that was not efficient to control the parasite.

Pig (Porcine) Activated Leukocyte Cell Adhesion Molecule (ALCAM) interaction partners

  1. ALCAM up-regulation by hypercholesterolemia suggests a side-specific spatial role in the recruitment of leukocytes to aortic valve sclerosis sites.

CD166 (ALCAM) Protein Profile

Protein Summary

This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found.

Gene names and symbols associated with ALCAM

  • activated leukocyte cell adhesion molecule a (alcama)
  • activated leukocyte cell adhesion molecule (alcam)
  • activated leukocyte cell adhesion molecule (ALCAM)
  • CD166 antigen homolog (cd166)
  • activated leukocyte cell adhesion molecule (Alcam)
  • AI853494 protein
  • ALCAM protein
  • BEN protein
  • CD166 protein
  • DM-GRASP protein
  • JC7 protein
  • MEMD protein
  • MuSC protein
  • SC1 protein

Protein level used designations for ALCAM

CD166 antigen homolog A , DM-GRASP homolog , neurolin , neurolin-a , zn5 / zn-5 antigen , zn8 / zn-8 antigen , activated leukocyte cell adhesion molecule , CD166 antigen , DM-GRASP II , CD166 antigen-like , CD166 antigen homolog , HB2 , KG-CAM , SB-10 antigen , activated leucocyte cell adhesion molecule , BEN glycoprotein , SC1 glycoprotein

GENE ID SPECIES
30194 Danio rerio
444425 Xenopus laevis
460565 Pan troglodytes
703777 Macaca mulatta
780210 Xenopus (Silurana) tropicalis
100061848 Equus caballus
100173616 Pongo abelii
100473255 Ailuropoda melanoleuca
100286453 Salmo salar
100015168 Monodelphis domestica
100598547 Nomascus leucogenys
214 Homo sapiens
11658 Mus musculus
79559 Rattus norvegicus
281614 Bos taurus
396092 Gallus gallus
100009305 Oryctolagus cuniculus
478550 Canis lupus familiaris
397269 Sus scrofa
100726386 Cavia porcellus
101114151 Ovis aries
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