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Activin A Receptor, Type IIB Proteins (ACVR2B)

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Additionally we are shipping Activin A Receptor, Type IIB Antibodies (108) and Activin A Receptor, Type IIB Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACVR2B 93 Q13705
ACVR2B 25366 P38445
ACVR2B 11481 P27040
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Top Activin A Receptor, Type IIB Proteins at antibodies-online.com

Showing 10 out of 30 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 200 μg Log in to see 11 Days
$286.00
Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Cynomolgus Fc Tag 100 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Mouse His tag,Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_HEK-293 Human His tag   0.2 mg Log in to see 2 to 3 Days
$515.63
Details

ACVR2B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , ,
, , ,
Rat (Rattus) ,

Mouse (Murine) , ,
, ,

Top referenced Activin A Receptor, Type IIB Proteins

  1. Cynomolgus ACVR2B Protein expressed in Human Cells - ABIN2009775 : Hildén, Tuuri, Erämaa, Ritvos: Expression of type II activin receptor genes during differentiation of human K562 cells and cDNA cloning of the human type IIB activin receptor. in Blood 1994 (PubMed)
    Show all 4 references for ABIN2009775

  2. Human ACVR2B Protein expressed in Human Cells - ABIN2002392 : Attisano, Wrana, Montalvo, Massagué: Activation of signalling by the activin receptor complex. in Molecular and cellular biology 1996 (PubMed)
    Show all 3 references for ABIN2002392

  3. Mouse (Murine) ACVR2B Protein expressed in Human Cells - ABIN2007451 : Persson, Souchelnytskyi, Franzén, Miyazono, ten Dijke, Heldin: Transforming growth factor (TGF-beta)-specific signaling by chimeric TGF-beta type II receptor with intracellular domain of activin type IIB receptor. in The Journal of biological chemistry 1997 (PubMed)
    Show all 3 references for ABIN2007451

More Proteins for Activin A Receptor, Type IIB (ACVR2B) Interaction Partners

Horse (Equine) Activin A Receptor, Type IIB (ACVR2B) interaction partners

  1. ActRIIB mRNA but not protein was decreased in skeletal muscle of obese compared with lean animals.

Human Activin A Receptor, Type IIB (ACVR2B) interaction partners

  1. ActR-IIB is expressed in male germ cells and Sertoli cells.

  2. Activin A (show INHBA Proteins) inhibited signaling by BMP-6 (show BMP6 Proteins) and BMP-9 (show GDF2 Proteins) by competing for type 2 receptors ACVR2A (show ACVR2A Proteins) and ACVR2B.

  3. We found that the AAAAA, AGGAG, and AGGGA haplotypes in ACVR2B were associated with susceptibility to Premature Ovarian Failure when they also had at least one CATAG haplotype in ADAMTS19.

  4. miR (show MLXIP Proteins)-21 interacts directly with the 3'-untranslated region of ACVR2B mRNA. Mechanical stretch suppressed ACVR2B protein levels in periodontal ligament stem cells. Gain- and loss of function of ACVR2B mediated the osteogenic differentiation of PDLSCs.

  5. Adenomyotic tissues express high levels of myostatin, follistatin, and activin type II receptors.

  6. Activin type IIB receptors are clearly demonstrable throughout the adult human hypothalamus and basal forebrain.

  7. After eccentric exercise, postmenopausal women not using hormone therapy (HT) expressed lower levels of ActRIIb while postmenopausal women using HT showed a heightened response.

  8. The interaction between all five miRNAs and ACVR2B was verified by an in vitro assay.

  9. Mutations in Activin A Receptor Type IIB were identified in 4 of the 47 patients (8.5%) with heterotaxy syndrome. Our results expand the mutation spectrum of monogenic heterotaxy syndrome with associated cardiac anomalies.

  10. discussion of crystal structure of kinase domain of ActRIIB; structural analysis may be of help in developing selective inhibitors [REVIEW]

Zebrafish Activin A Receptor, Type IIB (ACVR2B) interaction partners

  1. Roles in hindbrain and neural crest cell (NCC) patterning, in NCC derived pharyngeal arch cartilage and joint formation, and in tooth development.

Mouse (Murine) Activin A Receptor, Type IIB (ACVR2B) interaction partners

  1. Differential muscle hypertrophy is associated with satellite cell numbers and Akt (show AKT1 Proteins) pathway activation following activin type IIB receptor inhibition in Mtm1 (show MTM1 Proteins)

  2. ActRIIB inhibition enhanced energy expenditure only at ambient temperature or in the cold, where nonshivering thermogenesis is minimal, suggesting that brown fat activation plays a prominent role in the metabolic actions of ActRIIB inhibition.

  3. findings best fit a model in which BMP3 (show BMP3 Proteins), produced by mature bone cells, acts to reduce BMP signaling through Acvr2b in skeletal progenitor cells, limiting their differentiation to mature osteoblasts

  4. Functional redundancy in osteoblast differentiation is observed between bone morphogenetic protein receptor BMPR-II (show BMPR2 Proteins) and ActR-IIB.

  5. Inhibition of activin receptor type IIB increases strength and lifespan in myotubularin (show MTM1 Proteins)-deficient mice.

  6. Akt (show AKT1 Proteins) isoforms are not essential for for the ability of ActRIIB inhibition to regulate muscle size and function .

  7. ActRIIB plays a role in the specification of left-sidedness in developing mice

  8. Activin type IIB(ActRIIB) and its subfamily receptor, Activin type IIA (ActRIIA (show ACVR2A Proteins)), cooperatively mediate the Gdf11 (show GDF11 Proteins) signal in patterning the axial vertebrae

  9. ActRIIB is expressed in the early development of thymocytes.

  10. genetic evidence strongly suggested that ActRIIB and Smad2 (show SMAD2 Proteins) function in the same signaling pathway to regulate axial patterning and pancreas islet formation by means of a threshold mechanism.

Activin A Receptor, Type IIB (ACVR2B) Protein Profile

Protein Summary

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling\; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.

Gene names and symbols associated with ACVR2B

  • activin A receptor, type IIB (ACVR2B)
  • activin A receptor, type IIB (acvr2b)
  • activin A receptor, type IIB (Acvr2b)
  • activin receptor IIb (acvr2b)
  • activin receptor IIB (Acvr2b)
  • ActR-IIB protein
  • actr2b protein
  • actrIIb protein
  • ACVR2B protein
  • HTX4 protein
  • wu:fj97d11 protein
  • XAR1 protein

Protein level used designations for ACVR2B

activin A receptor, type IIB , activin receptor type IIB , activin receptor type-2B-like , activin type IIB receptor , activin receptor type-2B , ACTR-IIB , testicular activin receptor IIB , ActRIIB type II activin receptor B , Activine receptor 2b (transmembrane serine kinase) , activin receptor IIB

GENE ID SPECIES
443156 Ovis aries
460271 Pan troglodytes
100456564 Pongo abelii
448641 Xenopus (Silurana) tropicalis
696071 Macaca mulatta
100053588 Equus caballus
93 Homo sapiens
399277 Xenopus laevis
374213 Gallus gallus
485590 Canis lupus familiaris
448845 Sus scrofa
282131 Bos taurus
25366 Rattus norvegicus
30457 Danio rerio
11481 Mus musculus
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