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anti-Aggrecan (ACAN) Antibodies

ACAN encodes a calcium-binding mitochondrial carrier protein. Additionally we are shipping Aggrecan Kits (52) and Aggrecan Proteins (22) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ACAN 176  
ACAN 11595 Q61282
ACAN 58968 P07897
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Top anti-Aggrecan Antibodies at antibodies-online.com

Showing 10 out of 166 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated ICC, FACS, IHC (fro), IF, IHC (p), IHC, WB Figure 1 illustrates immunostaining of OA ABIN261460. Immunohistochemistry: Aggrecan Neoepitope Antibody [ABIN2614600] - Analysis of ACAN in mouse cartilage with hematoxylin counterstain. 0.1 mL Log in to see 5 to 7 Days
$408.19
Details
Chicken Mouse Un-conjugated ICC, IHC (fro), IF, IHC, MA Immunocytochemistry/Immunofluorescence: Aggrecan Antibody (CS-56) [ABIN2659140] - Coronal section of the developing cerebral cortex of an embryonic day 16 rat stained with Monoclonal Anti-Chondroitin Sulfate followed by fluorescein labeled Goat Anti-Mouse Ig. The chondroitin sulfate proteoglycan (CSPG) is most concentrated in the pia matter and the sub-plate (bright green layers). There is moderate staining in the intermediate zone, and there is very little CSPG in the cortical plate and ventricular zone. Data supplied by B. Miller, Washington Univ. School of Medicine, St. Louis, MO. Electron Microscopy: Aggrecan Antibody (CS-56) [ABIN2659140] - Normal rabbit aorta, Lowicryl K4M thin section, stained with Monoclonal Anti-Chondroitin Sulfate (ABIN2659140) and Goat Anti-Mouse IgM (u-chain specific) 10 nm gold. Counterstain was uranyl acetate and Reynold's lead citrate. Magnification 44,600x. (el=Elastin, col=Collagen). Data supplied by Z. Gallis, McGill University, Montreal. 0.1 mL Log in to see 5 to 7 Days
$538.13
Details
Cat Mouse Un-conjugated ELISA, ICC, IF, IHC, IHC (fro), IHC (p), WB   1 mL Log in to see 5 to 7 Days
$408.19
Details
Cow Mouse Un-conjugated EIA, IHC (fro), IHC (p), IP, WB   0.2 mg Log in to see 6 to 8 Days
$588.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p) Formalin-fixed and paraffin embedded rat synovial tissue labeled with Anti-Aggrecan1 Polyclonal Antibody, Unconjugated (ABIN673599) followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded mouse embryo labeled with Anti-Aggrecan1 Polyclonal Antibody, Unconjugated (ABIN673599) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$307.45
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from Jurkat cells, treated with Etoposide 25uM 60', using Aggrecan (Cleaved-Asp369) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using Aggrecan (Cleaved-Asp369) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Rat Rabbit Un-conjugated ICC, IHC, IP, WB 100 μg Log in to see 9 to 11 Days
$398.20
Details
Cow Mouse Un-conjugated IHC (fro), IHC (p), IHC, ELISA, WB   1 mL Log in to see 5 to 7 Days
$408.19
Details
Cow Mouse Un-conjugated IHC (fro), IHC (p), IHC, ELISA, WB Immunohistochemistry-Paraffin: Aggrecan Antibody (6-B-4) [ABIN258953] - Aggrecan on sheep intervertebral disc. Image from verified customer review. 1 mL Log in to see 5 to 7 Days
$381.94
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged AGC1 is approximately 0.1 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details

ACAN Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Aggrecan Antibodies

  1. Cat (Feline) Monoclonal Aggrecan Primary Antibody for ELISA, ICC - ABIN153389 : Little, Hughes, Curtis, Janusz, Bohne, Wang-Weigand, Taiwo, Mitchell, Otterness, Flannery, Caterson: Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation. in Matrix biology : journal of the International Society for Matrix Biology 2002 (PubMed)
    Show all 6 references for ABIN153389

  2. Human Polyclonal Aggrecan Primary Antibody for IF (p), IHC (p) - ABIN673599 : Lei, Li, Li, Gao, Chen, Jin: Mesenchymal stem cell characteristics of dental pulp and periodontal ligament stem cells after in vivo transplantation. in Biomaterials 2014 (PubMed)
    Show all 4 references for ABIN673599

  3. Cow (Bovine) Monoclonal Aggrecan Primary Antibody for IHC (fro), IHC (p) - ABIN259055 : Struglics, Larsson: A comparison of different purification methods of aggrecan fragments from human articular cartilage and synovial fluid. in Matrix biology : journal of the International Society for Matrix Biology 2010 (PubMed)
    Show all 3 references for ABIN259055

  4. Chicken Monoclonal Aggrecan Primary Antibody for ICC, IHC (fro) - ABIN265914 : Li, Gan, Wang, Xu, Song, Zhang, Li, Zhou: Biological Responses of the Immature Annulus Fibrosus to Dynamic Compression in a Disc Perfusion Culture. in Cells, tissues, organs 2016 (PubMed)
    Show all 3 references for ABIN265914

  5. Cow (Bovine) Polyclonal Aggrecan Primary Antibody for ICC, FACS - ABIN261460 : Huang, Lai, Hung, Wu, Liu, Ho: Advanced glycation end products cause collagen II reduction by activating Janus kinase/signal transducer and activator of transcription 3 pathway in porcine chondrocytes. in Rheumatology (Oxford, England) 2011 (PubMed)
    Show all 3 references for ABIN261460

  6. Cow (Bovine) Monoclonal Aggrecan Primary Antibody for EIA, IHC (fro) - ABIN1450192 : Anders, Mollenhauer, Beberhold, Kinne, Venbrocks: Gelatin-based haemostyptic Spongostan as a possible three-dimensional scaffold for a chondrocyte matrix?: an experimental study with bovine chondrocytes. in The Journal of bone and joint surgery. British volume 2009 (PubMed)
    Show all 3 references for ABIN1450192

  7. Rat (Rattus) Polyclonal Aggrecan Primary Antibody for ICC, IHC (fro) - ABIN1857938 : Dai, Chu, Tian, Song, Wang, Zhang, Zhang: Parathyroid hormone(1-34) exhibits more comprehensive effects than celecoxib in cartilage metabolism and maintaining subchondral bone micro-architecture in meniscectomized guinea pigs. in Osteoarthritis and cartilage 2016 (PubMed)

More Antibodies against Aggrecan Interaction Partners

Human Aggrecan (ACAN) interaction partners

  1. Decrease in mRNA expression of ACAN is associated with Osteoarthritis.

  2. Results showed an association between short alleles and lumbar disc herniation (LDH), corroborating the hypothesis that aggrecan with shorter repeat lengths can lead to a reduction in the physiological proteoglycan function of intervertebral disc hydration and, consequently, increased individual susceptibility to LDH.

  3. Citrullinated Proteoglycan (show Vcan Antibodies) Aggrecan is a new member of citrullinated proteins identified in human joints.

  4. Idiopathic short stature is due to novel heterozygous mutation of the aggrecan gene.

  5. rs2056202 and rs2292813 in SLC25A12 (show Slc25a12 Antibodies) may contribute significantly to autism spectrum disorders risk.

  6. Identification of homozygous deletion in ACAN and other candidate variants in familial classical Hodgkin lymphoma by exome sequencing.

  7. ACAN positive perineuronal nets and glial cells were decreased in the amygdala of szhizophrenia and bipolar disorder patients compared to controls.

  8. An underlying interaction between aggrecan VNTR and obesity in symptomatic lumbar disc herniation.

  9. The results suggest that regions within ACAN is associated with ACL (show ACLY Antibodies) injury susceptibility and that genetic sequence variability within genes encoding proteoglycans may potentially modulate the ligament fibril properties.

  10. results suggested that genetic variants in ACAN and MET are associated with HM. Functional roles of ACAN and MET in the development of HM need to be further investigated

Cow (Bovine) Aggrecan (ACAN) interaction partners

  1. the subsequent presentation of aggregan from ECM (show MMRN1 Antibodies) leads to CD4 (show CD4 Antibodies)(+) T-cell activation and effector cell formation.

  2. Data show that expression of mRNAs for aggrecan, collagen type II, and versican (show Vcan Antibodies) were significantly effected by the intervention.

  3. The delayed activation of proMMPs and the relatively low cleavage efficiency of MMPs compared to ADAMTS5 (show ADAMTS5 Antibodies) (aggrecanase (show ADAMTS4 Antibodies)) explains the minor contribution of the MMP enzymes to aggrecan catabolism in vivo.

  4. Self-adhesion between highly negatively charged aggrecan macromolecules extracted from bovine cartilage extracellular matrix, was investigated.

  5. aggrecanase (show ADAMTS4 Antibodies) activity (a) is responsible for early TNFalpha (show TNF Antibodies)-dependent aggrecan cleavage and GAG release in the meniscus and (b) might be involved in meniscal degeneration.

  6. Maintenance of structure and organization of extracellular matrix comprising chondron and pericellular microenvironment of chondrocytes in articular cartilage is important for distribution of newly synthesized aggrecan monomers within tissue.

  7. aggrecan plays a protective role in preventing degradation of collagen fibrils

  8. Changes in aggrecan and type II collagen (show COL2A1 Antibodies) promoter activity in transfected chondrocyte-laden cylindrical constructs were evaluated in response to a range of loading frequencies and durations.

  9. AGC1 mRNA expression level was upregulated by multidirectional articular motion.

  10. Homozygosity mapping in candidate regions in a small Dexter pedigree suggested aggrecan as the most likely candidate gene. Mutation screening revealed a 4-bp insertion in exon 11 (2266_2267insGGCA) and a second, rarer transition in exon 1 (-198C>T).

Mouse (Murine) Aggrecan (ACAN) interaction partners

  1. Aggrecan has a major role in regulating the expression of key growth factors and signaling molecules during development of cartilaginous tissue and is essential for proper chondrocyte organization, morphology, and survival.

  2. Aggrecan, link protein (show HAPLN1 Antibodies) and TN-R (show TNR Antibodies) were identified to be essential for the neuroprotective properties of the perineuronal net.

  3. the subsequent presentation of aggregan from ECM (show MMRN1 Antibodies) leads to CD4 (show CD4 Antibodies)(+) T-cell activation and effector cell formation.

  4. Runx3 (show RUNX3 Antibodies) positively regulates aggrecan expression and suggest that its function is more limited to cartilage development than to bone.

  5. The role of ADAMTS5 (show ADAMTS5 Antibodies) in tendon is to remove pericellular and interfibrillar aggrecan to maintain the molecular architecture responsible for normal tissue function.

  6. role of ADAMTS5 (show ADAMTS5 Antibodies) in dermal repair through CD44 (show CD44 Antibodies)-mediated aggrecan accumulation and modulation of transforming growth factor beta1 (TGFbeta1 (show TGFB1 Antibodies)) signaling

  7. CSGalNAcT-1 (show CSGALNACT1 Antibodies) is necessary for normal levels of endochondral ossification, and the decrease in CS amount in the growth plate by its absence causes a rapid catabolism of aggrecan.

  8. Data show that strong aggrecan gene expression was observed in growth plate and articular cartilage as well as the fibrocartilage of meniscus, trachea, and intervertebral disc.

  9. A remote upstream element regulates tissue-specific expression of the rat aggrecan gene

  10. the aggrecan promoter has an osteogenic protein-1 (show BMP7 Antibodies) responsive element

Horse (Equine) Aggrecan (ACAN) interaction partners

  1. At 0.1 and 1 microM concentrations, LE135 weakly but significantly increased chondral morphology scores, compared to untreated controls. Lack of aggrecan expression and lack of increased CII:CI ratio, compared to controls, did not affect chondrogenesis.

  2. degenerative suspensory ligament desmitis ligaments showed a 15-fold increase in aggrecan compared to normal

Pig (Porcine) Aggrecan (ACAN) interaction partners

  1. keratan sulphate in the interglobular domain of pig aggrecan has a microstructure that is distinct from keratan sulphate in the keratan sulphate-rich region

Rabbit Aggrecan (ACAN) interaction partners

  1. Aggrecan synthesis in intervertebral disc cells is stimulated by E-cadherin (show CDH1 Antibodies).

Aggrecan (ACAN) Antigen Profile

Protein Summary

This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in this gene may be associated with autism, and mutations in this gene may also be a cause of global cerebral hypomyelination. Alternatively spliced transcript variants have been observed for this gene.

Gene names and symbols associated with anti-Aggrecan (ACAN) Antibodies

  • aggrecan (LOC100380783) antibody
  • aggrecan (ACAN) antibody
  • aggrecan (Acan) antibody
  • aggrecan (AGC) antibody
  • solute carrier family 25 (aspartate/glutamate carrier), member 12 (SLC25A12) antibody
  • Agc antibody
  • Agc1 antibody
  • AGCAN antibody
  • ARALAR antibody
  • b2b183Clo antibody
  • cmd antibody
  • Cspg1 antibody
  • CSPGCP antibody
  • MSK16 antibody
  • SEDK antibody

Protein level used designations for anti-Aggrecan (ACAN) Antibodies

aggrecan , aggrecan core protein-like , aggrecan core protein , cartilage-specific proteoglycan core protein , chondroitin sulfate proteoglycan core protein 1 , large aggregating proteoglycan , CSPCP , aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122) , aggrecan epidermal growth factor-like domain-1 , aggrecan 1 , chondroitin sulfate proteoglycan 1 , large aggregating proteoglycan, antigen , aggrecan, structural proteoglycan of cartilage , cartilage aggregating proteoglycan , aggrecan interglobular domain , chondroitin sulfate proteoglycan core protein , araceli hiperlarga , calcium binding mitochondrial carrier superfamily member Aralar1 , calcium-binding mitochondrial carrier protein Aralar1 , mitochondrial aspartate glutamate carrier 1 , solute carrier family 25 (mitochondrial carrier, Aralar), member 12

GENE ID SPECIES
100380783 Salmo salar
100432072 Pongo abelii
176 Homo sapiens
280985 Bos taurus
403828 Canis lupus familiaris
11595 Mus musculus
58968 Rattus norvegicus
100033876 Equus caballus
397255 Sus scrofa
100731672 Cavia porcellus
395798 Gallus gallus
100009079 Oryctolagus cuniculus
100861256 Capra hircus
443001 Ovis aries
101084542 Felis catus
8604 Homo sapiens
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