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ACAN encodes a calcium-binding mitochondrial carrier protein. Additionally we are shipping Aggrecan Kits (59) and Aggrecan Proteins (21) and many more products for this protein.
Showing 10 out of 158 products:
Cat (Feline) Monoclonal Aggrecan Primary Antibody for ELISA, ICC - ABIN153389
Little, Hughes, Curtis, Janusz, Bohne, Wang-Weigand, Taiwo, Mitchell, Otterness, Flannery, Caterson: Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation. in Matrix biology : journal of the International Society for Matrix Biology 2002
Show all 6 references for ABIN153389
Cow (Bovine) Monoclonal Aggrecan Primary Antibody for IHC (fro), IHC (p) - ABIN259055
Struglics, Larsson: A comparison of different purification methods of aggrecan fragments from human articular cartilage and synovial fluid. in Matrix biology : journal of the International Society for Matrix Biology 2010
Show all 3 references for ABIN259055
Cow (Bovine) Polyclonal Aggrecan Primary Antibody for ICC, FACS - ABIN261460
Huang, Lai, Hung, Wu, Liu, Ho: Advanced glycation end products cause collagen II reduction by activating Janus kinase/signal transducer and activator of transcription 3 pathway in porcine chondrocytes. in Rheumatology (Oxford, England) 2011
Show all 3 references for ABIN261460
Cow (Bovine) Monoclonal Aggrecan Primary Antibody for EIA, IHC (fro) - ABIN1450192
Anders, Mollenhauer, Beberhold, Kinne, Venbrocks: Gelatin-based haemostyptic Spongostan as a possible three-dimensional scaffold for a chondrocyte matrix?: an experimental study with bovine chondrocytes. in The Journal of bone and joint surgery. British volume 2009
Show all 3 references for ABIN1450192
Human Polyclonal Aggrecan Primary Antibody for IF (p), IHC (p) - ABIN673599
Lei, Li, Li, Gao, Chen, Jin: Mesenchymal stem cell characteristics of dental pulp and periodontal ligament stem cells after in vivo transplantation. in Biomaterials 2014
Show all 2 references for ABIN673599
Rat (Rattus) Polyclonal Aggrecan Primary Antibody for ICC, IHC (fro) - ABIN1857938
Dai, Chu, Tian, Song, Wang, Zhang, Zhang: Parathyroid hormone(1-34) exhibits more comprehensive effects than celecoxib in cartilage metabolism and maintaining subchondral bone micro-architecture in meniscectomized guinea pigs. in Osteoarthritis and cartilage 2016
Citrullinated Proteoglycan (show Vcan Antibodies) Aggrecan is a new member of citrullinated proteins identified in human joints.
Idiopathic short stature is due to novel heterozygous mutation of the aggrecan gene.
rs2056202 and rs2292813 in SLC25A12 (show Slc25a12 Antibodies) may contribute significantly to autism spectrum disorders risk.
Identification of homozygous deletion in ACAN and other candidate variants in familial classical Hodgkin lymphoma by exome sequencing.
ACAN positive perineuronal nets and glial cells were decreased in the amygdala of szhizophrenia and bipolar disorder patients compared to controls.
An underlying interaction between aggrecan VNTR and obesity in symptomatic lumbar disc herniation.
The results suggest that regions within ACAN is associated with ACL (show ACLY Antibodies) injury susceptibility and that genetic sequence variability within genes encoding proteoglycans may potentially modulate the ligament fibril properties.
results suggested that genetic variants in ACAN and MET are associated with HM. Functional roles of ACAN and MET in the development of HM need to be further investigated
Data show there was no significant difference in the aggrecan (ACAN) rs1516797 genotype or allele distributions between the carpal tunnel syndrome (CTS (show TTR Antibodies)) and control groups.
Heterozygous mutations in ACAN can cause a mild skeletal dysplasia, which presents clinically as short stature with advanced bone age.
the subsequent presentation of aggregan from ECM (show MMRN1 Antibodies) leads to CD4 (show CD4 Antibodies)(+) T-cell activation and effector cell formation.
Data show that expression of mRNAs for aggrecan, collagen type II, and versican (show Vcan Antibodies) were significantly effected by the intervention.
The delayed activation of proMMPs and the relatively low cleavage efficiency of MMPs compared to ADAMTS5 (show ADAMTS5 Antibodies) (aggrecanase (show ADAMTS4 Antibodies)) explains the minor contribution of the MMP enzymes to aggrecan catabolism in vivo.
Self-adhesion between highly negatively charged aggrecan macromolecules extracted from bovine cartilage extracellular matrix, was investigated.
aggrecanase (show ADAMTS4 Antibodies) activity (a) is responsible for early TNFalpha (show TNF Antibodies)-dependent aggrecan cleavage and GAG release in the meniscus and (b) might be involved in meniscal degeneration.
Maintenance of structure and organization of extracellular matrix comprising chondron and pericellular microenvironment of chondrocytes in articular cartilage is important for distribution of newly synthesized aggrecan monomers within tissue.
aggrecan plays a protective role in preventing degradation of collagen fibrils
Changes in aggrecan and type II collagen (show COL2A1 Antibodies) promoter activity in transfected chondrocyte-laden cylindrical constructs were evaluated in response to a range of loading frequencies and durations.
AGC1 mRNA expression level was upregulated by multidirectional articular motion.
Homozygosity mapping in candidate regions in a small Dexter pedigree suggested aggrecan as the most likely candidate gene. Mutation screening revealed a 4-bp insertion in exon 11 (2266_2267insGGCA) and a second, rarer transition in exon 1 (-198C>T).
Aggrecan has a major role in regulating the expression of key growth factors and signaling molecules during development of cartilaginous tissue and is essential for proper chondrocyte organization, morphology, and survival.
Aggrecan, link protein (show HAPLN1 Antibodies) and TN-R (show TNR Antibodies) were identified to be essential for the neuroprotective properties of the perineuronal net.
Runx3 (show RUNX3 Antibodies) positively regulates aggrecan expression and suggest that its function is more limited to cartilage development than to bone.
The role of ADAMTS5 (show ADAMTS5 Antibodies) in tendon is to remove pericellular and interfibrillar aggrecan to maintain the molecular architecture responsible for normal tissue function.
role of ADAMTS5 (show ADAMTS5 Antibodies) in dermal repair through CD44 (show CD44 Antibodies)-mediated aggrecan accumulation and modulation of transforming growth factor beta1 (TGFbeta1 (show TGFB1 Antibodies)) signaling
CSGalNAcT-1 (show CSGALNACT1 Antibodies) is necessary for normal levels of endochondral ossification, and the decrease in CS amount in the growth plate by its absence causes a rapid catabolism of aggrecan.
Data show that strong aggrecan gene expression was observed in growth plate and articular cartilage as well as the fibrocartilage of meniscus, trachea, and intervertebral disc.
A remote upstream element regulates tissue-specific expression of the rat aggrecan gene
the aggrecan promoter has an osteogenic protein-1 (show BMP7 Antibodies) responsive element
At 0.1 and 1 microM concentrations, LE135 weakly but significantly increased chondral morphology scores, compared to untreated controls. Lack of aggrecan expression and lack of increased CII:CI ratio, compared to controls, did not affect chondrogenesis.
degenerative suspensory ligament desmitis ligaments showed a 15-fold increase in aggrecan compared to normal
keratan sulphate in the interglobular domain of pig aggrecan has a microstructure that is distinct from keratan sulphate in the keratan sulphate-rich region
Aggrecan synthesis in intervertebral disc cells is stimulated by E-cadherin (show CDH1 Antibodies).
This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in this gene may be associated with autism, and mutations in this gene may also be a cause of global cerebral hypomyelination. Alternatively spliced transcript variants have been observed for this gene.
, aggrecan core protein-like
, aggrecan core protein
, cartilage-specific proteoglycan core protein
, chondroitin sulfate proteoglycan core protein 1
, large aggregating proteoglycan
, aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122)
, aggrecan epidermal growth factor-like domain-1
, aggrecan 1
, chondroitin sulfate proteoglycan 1
, large aggregating proteoglycan, antigen
, aggrecan, structural proteoglycan of cartilage
, cartilage aggregating proteoglycan
, aggrecan interglobular domain
, chondroitin sulfate proteoglycan core protein
, araceli hiperlarga
, calcium binding mitochondrial carrier superfamily member Aralar1
, calcium-binding mitochondrial carrier protein Aralar1
, mitochondrial aspartate glutamate carrier 1
, solute carrier family 25 (mitochondrial carrier, Aralar), member 12