Amyloid P Component, serum Proteins (APCS)

The protein encoded by APCS is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. Additionally we are shipping Amyloid P Component, serum Antibodies (123) and Amyloid P Component, serum Kits (47) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
APCS 325 P02743
APCS 29339 P23680
APCS 20219 P12246
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Top Amyloid P Component, serum Proteins at antibodies-online.com

Showing 10 out of 34 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 100 μg Log in to see 2 to 3 Days
$275.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_HEK-293 Human Un-conjugated   10 μg Log in to see 10 to 12 Days
$103.27
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 15 to 18 Days
$720.00
Details
HOST_Mammalian Cells Mouse His tag   50 μg Log in to see 4 Days
$248.33
Details
HOST_Human Cells Human His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Human Cells Rat His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details

APCS Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , , ,
Rat (Rattus) , ,

Mouse (Murine) , , ,

Top referenced Amyloid P Component, serum Proteins

  1. Human APCS Protein expressed in HEK-293 - ABIN2666527 : Lu, Marnell, Marjon, Mold, Du Clos, Sun: Structural recognition and functional activation of FcgammaR by innate pentraxins. in Nature 2008 (PubMed)
    Show all 6 references for 2666527

  2. Human APCS Protein expressed in HEK-293 Cells - ABIN2180596 : Kiernan, Nedelkov, Tubbs, Niederkofler, Nelson: Proteomic characterization of novel serum amyloid P component variants from human plasma and urine. in Proteomics 2004 (PubMed)
    Show all 4 references for 2180596

More Proteins for Amyloid P Component, serum (APCS) Interaction Partners

Human Amyloid P Component, serum (APCS) interaction partners

  1. The findings suggest that the F57I mutation affects the aggregation process of lysozyme (show LYZ Proteins) resulting in the formation of cytotoxic species and that SAP is able to prevent cell death in the F57I flies by preventing accumulation of toxic F57I structures.

  2. Data suggest that SAP (serum amyloid P-component) interacts with at least 33 proteins/ligands in plasma containing physiological calcium levels; these ligands can be categorized to include apolipoproteins, complement system proteins, coagulation proteins, and components that regulate proteolysis.

  3. Data suggest that serum haptoglobin, fetuin-A, platelet factor-4, hs-CRP (high sensitive-C-reactive protein), SAP (serum amyloid P), AGP (alpha1-acid glycoprotein) levels of adolescents with metabolic syndrome are significantly higher than those of controls subjects.

  4. SNPs in APCS were associated with late age at onset in familial amyloid polyneuropathy.

  5. Data suggest that serum amyloid P (SAP) activates CD209 DC-SIGN (show CD209 Proteins) to regulate the innate immune system differently from C-reactive protein (CRP (show CRP Proteins)), and that DC-SIGN (show CD209 Proteins) is a target for antifibrotics.

  6. Here, it is reported that X-ray analysis of the SAP complex with CPHPC and cadmium ions provides higher resolution detail of the interaction than is observed with calcium ions.

  7. Compared to wildtype C57BL/6 mice, we find that in Apcs-/- "SAP knock-out" mice, bleomycin induces a more persistent inflammatory response and increased fibrosis.

  8. The effects of SAP and Xiapex (Collagenase Clostridium histolyticum) on fibrocytes derived from Dupuytren's disease, was evaluated.

  9. plasma protein serum amyloid P binds to FcgammaRI (show FCGR1A Proteins) on monocytes to inhibit fibrocyte differentiation, and binds to FcgammaRIIa on neutrophils to reduce neutrophil adhesion.

  10. In the late phase post-myocardial infarct there is a coordinated decrease in immune response-inflammation proteins, except for SAP which showed an increase related to the specific activation of the classical complement pathway.

Mouse (Murine) Amyloid P Component, serum (APCS) interaction partners

  1. SAP deficiency mitigated foam cell formation and atherosclerotic development in apoE (show APOE Proteins)(-/-) mice, due to reduction in macrophages recruitment, polarization and pro-inflammatory cytokines

  2. Data suggest that serum amyloid P (SAP) activates CD209 DC-SIGN (show CD209 Proteins) to regulate the innate immune system differently from C-reactive protein (CRP (show CRP Proteins)), and that DC-SIGN (show CD209 Proteins) is a target for antifibrotics.

  3. observations suggest that serum amyloid P, at least in part, uses FcgammaRI (show FCGR1A Proteins) and FcRgamma (show FCER1G Proteins) to inhibit fibrocyte differentiation

  4. Bglu3 is confirmed to be a locus affecting diabetes susceptibility, and Apcs is a probable candidate gene.

  5. binding of SAP to ALD-DNA could switch macrophage phenotypic polarization from proinflammatory M2b to anti-inflammatory M2a via PI3K/Akt (show AKT1 Proteins)-ERK (show EPHB2 Proteins) signaling activation, thus exerting protective and therapeutic interventions on murine lupus nephritis

  6. SAP has an effect on macrophages in fibrotic lung disease

  7. sFRP4 (show SFRP4 Proteins) negatively regulates bone formation without disrupting phosphorus homeostasis.

  8. Binding of mouse and human SAP to immobilized influenza virus was compared. Mouse SAP bound much less avidly than human SAP.mouse SAP apparently plays no significant role during infection of mice with influenza virus.

  9. Targeted pharmacological depletion of serum amyloid P component for treatment of amyloidosis

  10. during murine tuberculosis (TB) SAP levels were increased; purified mouse SAP inhibited the intra-alveolar macrophage M. tuberculosis growth, in vitro; SAP may thus contribute both to the pathogenesis and pulmonary innate immunity in TB

Amyloid P Component, serum (APCS) Protein Profile

Protein Summary

The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo.

Gene names and symbols associated with APCS

  • amyloid P component, serum (APCS)
  • amyloid P component, serum (Apcs)
  • C-reactive protein, pentraxin-related (CRP)
  • serum amyloid P-component (Apcs)
  • serum amyloid P-component-like (LOC100352593)
  • APCS protein
  • PTX2 protein
  • Sap protein

Protein level used designations for APCS

amyloid P component, serum , pentraxin , C-reactive protein , amyloid P component serum , 9.5S alpha-1-glycoprotein , pentaxin-related , serum amyloid P-component , serum amyloid P component , Serum amyloid P-component , SAP , APCS amyloid P-component serum protein

GENE ID SPECIES
457427 Pan troglodytes
100126558 Meleagris gallopavo
325 Homo sapiens
396921 Sus scrofa
29339 Rattus norvegicus
100726823 Cavia porcellus
514488 Bos taurus
776376 Gallus gallus
20219 Mus musculus
100352593 Oryctolagus cuniculus
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