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Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Additionally we are shipping APOE Kits (133) and APOE Proteins (50) and many more products for this protein.
Showing 10 out of 353 products:
Human Monoclonal APOE Primary Antibody for CyTOF, ELISA - ABIN258785
Wahrle, Jiang, Parsadanian, Hartman, Bales, Paul, Holtzman: Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease. in The Journal of biological chemistry 2005
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Human Monoclonal APOE Primary Antibody for EIA, IHC (fro) - ABIN1105420
Dergunov, Shuvaev, Yanushevskaja: Quaternary structure of apolipoprotein E in solution: fluorimetric, chromatographic and immunochemical studies. in Biological chemistry Hoppe-Seyler 1992
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Human Polyclonal APOE Primary Antibody for IHC (p), ELISA - ABIN1997537
Li, Jiang, Qu, Yao, Cai, Chen, Peng: Hepatocyte nuclear factor 4? and downstream secreted phospholipase A2 GXIIB regulate production of infectious hepatitis C virus. in Journal of virology 2013
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Human Monoclonal APOE Primary Antibody for FACS, IHC - ABIN968962
Karpouzis, Caridha, Tripsianis, Michailidis, Martinis, Veletza: Apolipoprotein E gene polymorphism in psoriasis. in Archives of dermatological research 2009
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Human Polyclonal APOE Primary Antibody for IHC, ELISA - ABIN185375
Dodart, Marr, Koistinaho, Gregersen, Malkani, Verma, Paul: Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease. in Proceedings of the National Academy of Sciences of the United States of America 2005
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Human Polyclonal APOE Primary Antibody for IHC, WB - ABIN2774066
Ho, Niti, Yap, Kua, Ng: Metabolic syndrome and cognitive decline in chinese older adults: results from the singapore longitudinal ageing studies. in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2008
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Human Polyclonal APOE Primary Antibody for EIA, IHC (p) - ABIN4620416
Wood, Fullerton, El-Sohemy, Bakovic: Interactions between hepatic lipase and apolipoprotein E gene polymorphisms affect serum lipid profiles of healthy Canadian adults. in Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme 2008
Human Polyclonal APOE Primary Antibody for IHC (p), WB - ABIN391849
Benga, Krieger, Dimitrova, Zeisel, Parnot, Lupberger, Hildt, Luo, McLauchlan, Baumert, Schuster: Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles. in Hepatology (Baltimore, Md.) 2009
by comparing the evolution of CIA (show NCOA5 Antibodies) between several strains of mutant mice with different levels of serum ApoE and cholesterol, our results demonstrate that both hypercholesterolaemia and ApoE regulate the intensity of in-vivo systemic autoimmune responses.
prolonged treatment of apoE(-/-) mice with Alda-1 led to the beneficial changes in the expression of genes and proteins related to neuroplasticity and mitochondrial function.
clopidogrel can effectively delay the development and progression of 'de-novo' atherosclerosis in ApoE knockout mice.
CCL5 (show CCL5 Antibodies) deficiency decreased neointima formation after carotid injury in ApoE-/- mice.
The values in the Apoe-deficient mice were much greater than in the Ldlr (show LDLR Antibodies) mice. These findings suggest that Apoe-deficient mice showed increased susceptibility to inflammation-associated colorectal carcinogenesis due to their high reactivity to inflammatory stimuli.
the effect of 25-hydroxyvitamin D-1-alpha-hydroxylase on the atherosclerosis disease both in apolipoprotein (apo) E-/- mice and wild-type mice, was investigated.
DPP (show DSPP Antibodies)-4I, MK0626, but not native incretins has protective effects against AAA (show AAAS Antibodies) in Ang II (show AGT Antibodies)-infused Apoe/ mice via suppression of inflammation, proteolysis, and fibrosis in the aortic wall
Results suggest that the pathological effects of ApoE4 in astrocytes may be mediated by impaired autophagy and by the concomitant impaired ability of the cells to remove Abeta (show APP Antibodies) plaques
Treatment of an Alzheimer's disease mouse model with genistein results in a remarkable and rapid improvement in various parameters of cognition; a lowering of Abeta (show APP Antibodies) levels in brain, in the number and the area of amyloid plaques (confirmed in vivo by positron emission tomography) as well as in microglial reactivity; and incubation of primary astrocytes with genistein results in a PPARgamma (show PPARG Antibodies)-mediated increased release of ...
Results demonstrate that iron alters ApoE protein levels in neurons and astrocytes, and also affects the secretion of ApoE fragments, show that ApoE mRNA expression is enhanced by iron in astrocytes but not in neurons
we explored the frequency specific effects of ApoE e4 allele on the default mode network (DMN (show SYNM Antibodies)) and the salience network (SN) functional connectivity
In cognitively normal older adults, Abeta (show APP Antibodies)+ is associated with memory decline in epsilon4 noncarriers; however, the rate of this decline is much slower than that observed in epsilon4 carriers. These data indicate that the processes by which epsilon4 carriage increases the rate of Abeta (show APP Antibodies)-related cognitive decline occur in the preclinical stage of Alzheimer disease.
This study showed that APOE genotype affects APOE distribution in human brain samples.
Study found that myoinositol levels are elevated already at asymptomatic stages of Alzheimer disease; myoinositol/creatine concentrations were increased in healthy APOE epsilon4 carriers with normal CSF (show CSF2 Antibodies) Abeta42 levels, suggesting that myoinositol levels may reveal regional brain consequences of APOE epsilon4 before detectable amyloid pathology
Thus, the present protocol may facilitate simple, fast and costeffective screening for important SNPs, as demonstrated by the evaluation of the prevalence of ApoE variants in a Han Chinese cohort.
The study suggested that the APOE genotype and haplotype significantly associated with plasma TC and LDL-C level in Vietnamese children. The association of APOE genotype with hypoalphalipoproteinemia was independent of obesity-related traits.
According to multivariate regression logistic analyses of this study, higher cortisol levels, lower high-density lipoprotein (HDL (show HSD11B1 Antibodies)-c) and very low-density lipoprotein (VLDL-c), presence of epsilon4 allele of APOE, and aging were associated with cognitive impairment no dementia and dementia.
These findings indicated that variants in TOMM40 (show TOMM40 Antibodies)/APOE/APOC1 (show APOC1 Antibodies) region might be associated with human longevity. Further studies are needed to identify the causal genetic variants influencing human longevity.
Metaanalysis: the epsilon2 allele in APOE may appear as a risk factor for premature coronary artery disease in Asians while a protective factor in Caucasians and that the epsilon4 allele acted as a genetic risk factor for premature coronary artery disease
APOE rs429358 variant C allele and 4 allele are associated with the anti-epileptic drugs resistance in Han Chinese patients.
we report the efficient creation of an APOE knockout rabbit by using zinc finger nucleases. The knockout rabbits had drastically elevated cholesterol and moderately increased triglyceride levels, mimicking symptoms in human heart disease.
The molar ratio ApoE/ApoA-I (show APOA1 Antibodies) is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.
ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (show HSD11B1 Antibodies) paraoxonase activity
The identification of disulphide-linked apoE dimers in cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences.
These data suggest that the -155T>A mutation in the promoter region of the porcine APOE gene is an important functional variant
Nonesterified fatty acids significantly inhibit the expression of ApoB100 (show APOB Antibodies), ApoE, MTP (show MTTP Antibodies), and LDLR (show LDLR Antibodies), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
Bovine apoE contents in triglyceride-rich lipoproteins are modulated by nutritional treatment and closely associated with triglyceride-rich lipoprotein metabolism
apoE-containing particles, which increased during the lactating stage, were not associated with HDL (show HSD11B1 Antibodies) particles, and lipid-free forms were included in cow plasma
after calving the apolipoprotein B(100 (show APOB Antibodies)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP (show MTTP Antibodies)) and apolipoprotein E messenger RNA abundance were higher in the liver
The study found no coding variation within and between chimpanzee populations, suggesting that the maintenance of functionally diverse APOE polymorphisms is a unique feature of human evolution.
ApoE evolution and very likely the evolution of other apolipoproteins are influenced by feeding environment and diet of humans, chimpanzees and various other species.
In the hippocampus APOE protein levels were higher in good spatial performers than poor spatial performers animals
Allele frequencies of the ApoE gene found show that allele epsilon3 has one of the highest frequencies and epsilon4 allele one of the lowest compared to other population groups in the world
There was significantly more apoE immunoreactivity in the prefrontal cortex and hippocampus of aged animals compared to adult or middle-aged animals.
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
, apolipoprotein E3