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The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Additionally we are shipping Ataxin 2-Binding Protein 1 Antibodies (51) and Ataxin 2-Binding Protein 1 Kits (3) and many more products for this protein.
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This study underlines that tightly regulated splicing is necessary for unconstrained cardiac function and renders the splicing regulator (show PTBP2 Proteins) rbfox1 an interesting target for investigation in human heart failure and cardiomyopathy.
When the abundance of the FOX1 gene product is reduced, Chlamydomonas cells grow poorly in iron-deficient medium, but not in iron-replete medium, suggesting that FOX1-dependent iron uptake is a high-affinity pathway.
study identifies regulation of RNA splicing by RBFox1 as an important player in transcriptome reprogramming during heart failure that influence pathogenesis of the disease
The SNP rs1478697 in A2BP1 may be associated with antipsychotic induced weight gain induced by 8-week treatment with olanzapine.
Cytoplasmic Rbfox1 target mRNAs were enriched in genes involved in cortical development and autism
The Genome-wide association study showed a significant association for a variant within the RBFOX1 gene with generalized anxiety disorder.
This study suggested that exonic RBFOX1 deletions are involved in the broad spectrum of focal and generalized epilepsies.
RBFOX proteins can facilitate the splicing of micro-exons. We also found that PTBP1 (show PTBP1 Proteins) likely regulates the inclusion of micro-exons, possibly by repressing the inclusion of micro-exons that are enhanced by RBFOX proteins and other splicing factors.[RBFOX]
Copy Number Variations in CTNNA3 (show CTNNA3 Proteins) and RBFOX1 Associate with Pediatric Food Allergy
Reduced RBFOX1 activity in myotonic dystrophy type 1 tissues may amplify several of the splicing alterations caused by the deficiency in MBNL1 (show MBNL1 Proteins).
RBFOX1 promotes the skipping of APP (show APP Proteins) exon 7, but not the inclusion of exon 8.
Gain- and loss-of-function experiments demonstrated that Rbfox1 and Rbfox2 (show RBM9 Proteins) cooperate in promoting Mef2D (show MEF2D Proteins) splicing and subsequent myogenesis.
Rbfox1 regulates RNA splicing required for skeletal muscle structure and function.
Fox-1, expressed specifically in the neural cell stage, promoted Mef2c (show MEF2C Proteins) exon beta inclusion via the GCAUG.
The results suggest that in neuronal tissues A2BP1 plays important roles, which are regulated in a spatiotemporal manner.
our results suggest that a component of FSHD pathogenesis may arise by over-expression of FRG1 (show FRG1 Proteins), reducing Rbfox1 levels and leading to aberrant expression of an altered Calpain 3 (show CAPN3 Proteins) protein through dysregulated splicing
Fox-1 splices mRNAs encoding proteins important in synaptic transmission and membrane excitation.
The splicing regulator (show PTBP2 Proteins) Rbfox1 controls neuronal excitation in the mammalian brain.
These data indicate that A2BP1 mutations may clinically affect very selective forebrain neuron types from early periods of development.
The present study provides evidence that alternative neuronal nPTB (show PTBP2 Proteins) and Fox-1/Fox-2 (show RBM9 Proteins) isoforms are also produced in lenses
The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
RNA binding protein, fox-1 homolog (C. elegans) 1
, ataxin 2-binding protein 1
, RNA binding protein fox-1 homolog 1
, ataxin-2-binding protein 1
, fox-1 homolog A
, hexaribonucleotide-binding protein 1
, ataxin 2 binding protein 1
, hexaribonucleotide binding protein 1
, RNA binding protein, fox-1 homolog 1