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Regulates autophagy and development of the nervous system. Additionally we are shipping AMBRA1 Proteins (3) and many more products for this protein.
Showing 10 out of 112 products:
Human Polyclonal AMBRA1 Primary Antibody for ICC, IF - ABIN446495
Falasca, Torino, Marconi, Costantini, Pompeo, Sentinelli, De Salvo, Patrizio, Padula, Gallucci, Piacentini, Malorni: AMBRA1 and SQSTM1 expression pattern in prostate cancer. in Apoptosis : an international journal on programmed cell death 2015
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Human Polyclonal AMBRA1 Primary Antibody for IP, IHC - ABIN347117
Fimia, Stoykova, Romagnoli, Giunta, Di Bartolomeo, Nardacci, Corazzari, Fuoco, Ucar, Schwartz, Gruss, Piacentini, Chowdhury, Cecconi: Ambra1 regulates autophagy and development of the nervous system. in Nature 2007
Show all 3 Pubmed References
Human Polyclonal AMBRA1 Primary Antibody for IF (p), IHC (p) - ABIN704741
Song, Kou, Zou, Gao, Zeng, Xie: Involvement of autophagy in tri-ortho-cresyl phosphate- induced delayed neuropathy in hens. in Neurochemistry international 2013
Ambra1 knockdown causes severe embryonic malformations.
The results suggested that AMBRA1 is a core factor that controls both autophagy and metabolic regulation.
we further measured the expression of autophagy protein BECLIN1 (show BECN1 Antibodies) in hippocampus of all mice
a de-regulation of c-Myc (show MYC Antibodies) correlates with increased tumorigenesis in AMBRA1-defective systems, thus supporting a role for AMBRA1 as a haploinsufficient tumour suppressor gene.
found Smad2 (show SMAD2 Antibodies) as the major transcriptional regulator of autophagy that targets beclin1 (BECN1 (show BECN1 Antibodies)) gene expression. Smad2 (show SMAD2 Antibodies), but not Smad3 (show SMAD3 Antibodies), acts as a repressor upstream of the BECN1 (show BECN1 Antibodies) promoter region
AMBRA1 interacts with cullin E3 ubiquitin ligases to regulate autophagy dynamics
These results reveal new roles for autophagy-related molecules Atg5 (show ATG5 Antibodies) and Ambra1 during early neuronal differentiation of stem/progenitor cells.
These data identify interaction of Parkin (show PARK2 Antibodies) with Ambra1 as a key mechanism for induction of the final clearance step of Parkin (show PARK2 Antibodies)-mediated mitophagy.
Ambra1 functional deficiency in mouse embryos leads to severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic cell death
Results show that the expression of AMBRA1 and Beclin-1 (show BECN1 Antibodies) is increased in human gastric adenocarcinoma (GC) tissues. High protein expression of AMBRA1 and Beclin-1 (show BECN1 Antibodies) is correlated with tumor invasion and is an independent poor prognostic marker in GC patients.
Ambra1 is a crucial regulator of autophagy and apoptosis in ovarian cancer cells subject to cisplatin to maintain the balance between autophagy and apoptosis. Ambra1-targeting inhibition might sensitize ovarian cancer cells to chemotherapy.
An increased expression of AMBRA1 and SQSTM1 (show SQSTM1 Antibodies).
Ambra1 mRNA translocation to P-bodies and translational suppression correlated with increased cell death.
Both AMBRA1 and BECLIN 1 (show BECN1 Antibodies) affect c-Myc (show MYC Antibodies) regulation, but through two different pathways.
Ambra1 is a crucial regulator of autophagy and apoptosis in colorectal cancer cells
A schizophrenia-related risk variant in AMBRA1 (rs11819869) is involved in various aspects of impulsivity, and this involvement occurs on a behavioral as well as an imaging genetics level.
Data suggest that activated autophagy is associated with the progression of pancreatic ductal adenocarcinoma and that the overexpression of autophagy-related proteins Atg5 (show ATG5 Antibodies), Ambra1, beclin-1 (show BECN1 Antibodies), LC3B (show MAP1LC3B Antibodies) and Bif-1 (show ZBTB24 Antibodies) is significantly correlated with poor outcome.
Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation.
autophagy/beclin-1 regulator 1
, activating molecule in BECN1-regulated autophagy protein 1-like
, activating molecule in BECN1-regulated autophagy protein 1
, activating molecule in Beclin1-regulated autophagy
, ischemia related factor NYW-1
, DDB1 and CUL4 associated factor 3
, WD repeat domain 94
, activating molecule in beclin-1-regulated autophagy