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B Lymphoid Tyrosine Kinase Proteins (BLK)

BLK encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. Additionally we are shipping BLK Antibodies (170) and BLK Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BLK 12143 P16277
BLK 640 P51451
Rat BLK BLK 364403  
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Top BLK Proteins at antibodies-online.com

Showing 9 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human GST tag 50 μg Log in to see 16 Days
$338.80
Details
HOST_Baculovirus infected Insect Cells Human Un-conjugated 5 μg Log in to see 2 to 3 Days
$336.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 Days
$385.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Hi-5 Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$498.21
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details

BLK Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , , ,
,

Top referenced BLK Proteins

  1. Human BLK Protein expressed in Baculovirus infected Insect Cells - ABIN2003390 : Drebin, Hartzell, Griffin, Campbell, Niederhuber: Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk). in Oncogene 1995 (PubMed)
    Show all 4 references for ABIN2003390

  2. Human BLK Protein expressed in Escherichia coli (E. coli) - ABIN667955 : Dymecki, Niederhuber, Desiderio: Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells. in Science (New York, N.Y.) 1990 (PubMed)
    Show all 2 references for ABIN667955

More Proteins for B Lymphoid Tyrosine Kinase (BLK) Interaction Partners

Mouse (Murine) B Lymphoid Tyrosine Kinase (BLK) interaction partners

  1. our study reveals a previously unappreciated role of reduced BLK (show BIK Proteins) expression on extraperitoneal accumulation of B1a cells in mice, as well as the presence of IgG autoantibodies and B1-like cells in humans.

  2. BLK (show BIK Proteins) risk alleles confer susceptibility to systemic lupus erythematosus through the dysregulation of a proinflammatory cytokine network.

  3. this study has revealed a previously unappreciated role for Blk (show BIK Proteins) in the development and activation of MZ B cells

  4. BCR-ABL (show ABL1 Proteins) downregulates the Blk (show BIK Proteins) gene (encoding B-lymphoid kinase) through c-Myc (show MYC Proteins) in leukemic stem cells in chronic myeloid leukemia (show BCL11A Proteins)

  5. Data suggest a role of tyrosine kinase (show TYRO3 Proteins) Btk (show BTK Proteins) in the regulation of immune cell unctions and innate inflammatory response.

  6. Analysis of Blk (show BIK Proteins)-deficient mice reveals that Blk (show BIK Proteins) is required for the development of IL-17 (show IL17A Proteins)-producing gammadelta T cell effectors and plays a role in regulating thymus cellularity during ontogeny.

  7. sustained activation of Blk (show BIK Proteins) induces responses normally associated with the pre-BCR (show BCR Proteins).

  8. Blk (show BIK Proteins), being exceptionally highly expressed in the initial segment, is suggested to have a role in the differentiation of this segment of the epididymis.

Human B Lymphoid Tyrosine Kinase (BLK) interaction partners

  1. Report a novel BLK gene variant in common variable immunodeficiency-patients that causes suppressed B-cell proliferation and reduced ability of B-cells to elicit antigen-specific CD4 (show CD4 Proteins)(+) T-cell responses.

  2. A major mechanism underlying the BLK association with autoimmune disease involves lowered thresholds for basal B cell receptor signaling, enhanced B cell-T cell interactions, and altered patterns of isotype switching.

  3. our study reveals a previously unappreciated role of reduced BLK expression on extraperitoneal accumulation of B1a cells in mice, as well as the presence of IgG autoantibodies and B1-like cells in humans.

  4. Results support previous findings that vaiants in the RHOB and FAM167A-BLK genes may be associated with susceptibility to systemic sclerosis.

  5. These results place Blk upstream of the p190RhoGAP (show GRLF1 Proteins)-RhoA (show RHOA Proteins) pathway in Galpha13 (show GNA13 Proteins)-activated cells, overall representing an opposing signaling module during CXCL12 (show CXCL12 Proteins)-triggered invasion.

  6. Report role of BLK genetic variants in confering risk of systemic lupus erythematosus in Chinese population.

  7. The observations suggested that C8orf13-BLK, in combination with STAT4 (show STAT4 Proteins), plays a pivotal role in creating genetic susceptibility to polymyositis/dermatomyositis in Japanese individuals.

  8. B-lymphoid tyrosine kinase (Blk) is an oncogene (show RAB1A Proteins) and a potential target for therapy with dasatinib in cutaneous T-cell lymphoma

  9. results demonstrated that both lupus-associated functional variants contribute to the autoimmune disease association by modulating transcription of BLK in B cells and thus potentially altering immune responses

  10. Our study confirms evidence for epistasis between BLK and BANK1 (show BANK1 Proteins) in systemic lupus erythematosis from a Chinese population for the first time.

BLK Protein Profile

Protein Summary

This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors.

Gene names and symbols associated with BLK

  • B lymphoid tyrosine kinase (blk)
  • B lymphoid tyrosine kinase (BLK)
  • B lymphoid kinase (Blk)
  • B lymphoid tyrosine kinase (Blk)
  • bltk protein
  • MODY11 protein
  • si:dkey-33i22.2 protein
  • zgc:136231 protein

Protein level used designations for BLK

B lymphoid kinase , tyrosine-protein kinase Blk , B lymphoid tyrosine kinase , tyrosine-protein kinase Blk-like , b lymphocyte kinase , p55-Blk , BLK nonreceptor tyrosine kinase

GENE ID SPECIES
567764 Danio rerio
100412187 Callithrix jacchus
100442545 Pongo abelii
100479355 Ailuropoda melanoleuca
100559493 Anolis carolinensis
100601418 Nomascus leucogenys
12143 Mus musculus
640 Homo sapiens
486080 Canis lupus familiaris
532587 Bos taurus
364403 Rattus norvegicus
422035 Gallus gallus
Selected quality suppliers for BLK Proteins (BLK)
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