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BLK encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. Additionally we are shipping BLK Antibodies (170) and BLK Kits (5) and many more products for this protein.
Showing 9 out of 11 products:
Human BLK Protein expressed in Baculovirus infected Insect Cells - ABIN2003390
Drebin, Hartzell, Griffin, Campbell, Niederhuber: Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk). in Oncogene 1995
Show all 4 references for ABIN2003390
Human BLK Protein expressed in Escherichia coli (E. coli) - ABIN667955
Dymecki, Niederhuber, Desiderio: Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells. in Science (New York, N.Y.) 1990
Show all 2 references for ABIN667955
our study reveals a previously unappreciated role of reduced BLK (show BIK Proteins) expression on extraperitoneal accumulation of B1a cells in mice, as well as the presence of IgG autoantibodies and B1-like cells in humans.
BLK (show BIK Proteins) risk alleles confer susceptibility to systemic lupus erythematosus through the dysregulation of a proinflammatory cytokine network.
this study has revealed a previously unappreciated role for Blk (show BIK Proteins) in the development and activation of MZ B cells
BCR-ABL (show ABL1 Proteins) downregulates the Blk (show BIK Proteins) gene (encoding B-lymphoid kinase) through c-Myc (show MYC Proteins) in leukemic stem cells in chronic myeloid leukemia (show BCL11A Proteins)
Data suggest a role of tyrosine kinase (show TYRO3 Proteins) Btk (show BTK Proteins) in the regulation of immune cell unctions and innate inflammatory response.
Analysis of Blk (show BIK Proteins)-deficient mice reveals that Blk (show BIK Proteins) is required for the development of IL-17 (show IL17A Proteins)-producing gammadelta T cell effectors and plays a role in regulating thymus cellularity during ontogeny.
sustained activation of Blk (show BIK Proteins) induces responses normally associated with the pre-BCR (show BCR Proteins).
Blk (show BIK Proteins), being exceptionally highly expressed in the initial segment, is suggested to have a role in the differentiation of this segment of the epididymis.
Report a novel BLK gene variant in common variable immunodeficiency-patients that causes suppressed B-cell proliferation and reduced ability of B-cells to elicit antigen-specific CD4 (show CD4 Proteins)(+) T-cell responses.
A major mechanism underlying the BLK association with autoimmune disease involves lowered thresholds for basal B cell receptor signaling, enhanced B cell-T cell interactions, and altered patterns of isotype switching.
our study reveals a previously unappreciated role of reduced BLK expression on extraperitoneal accumulation of B1a cells in mice, as well as the presence of IgG autoantibodies and B1-like cells in humans.
Results support previous findings that vaiants in the RHOB and FAM167A-BLK genes may be associated with susceptibility to systemic sclerosis.
These results place Blk upstream of the p190RhoGAP (show GRLF1 Proteins)-RhoA (show RHOA Proteins) pathway in Galpha13 (show GNA13 Proteins)-activated cells, overall representing an opposing signaling module during CXCL12 (show CXCL12 Proteins)-triggered invasion.
Report role of BLK genetic variants in confering risk of systemic lupus erythematosus in Chinese population.
The observations suggested that C8orf13-BLK, in combination with STAT4 (show STAT4 Proteins), plays a pivotal role in creating genetic susceptibility to polymyositis/dermatomyositis in Japanese individuals.
B-lymphoid tyrosine kinase (Blk) is an oncogene (show RAB1A Proteins) and a potential target for therapy with dasatinib in cutaneous T-cell lymphoma
results demonstrated that both lupus-associated functional variants contribute to the autoimmune disease association by modulating transcription of BLK in B cells and thus potentially altering immune responses
Our study confirms evidence for epistasis between BLK and BANK1 (show BANK1 Proteins) in systemic lupus erythematosis from a Chinese population for the first time.
This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors.
B lymphoid kinase
, tyrosine-protein kinase Blk
, B lymphoid tyrosine kinase
, tyrosine-protein kinase Blk-like
, b lymphocyte kinase
, BLK nonreceptor tyrosine kinase