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BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD\; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Additionally we are shipping Bestrophin 3 Antibodies (64) and Bestrophin 3 Kits (4) and many more products for this protein.
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results demonstrated that Best-3 is an endogenous inhibitor of NF-kappaB (show NFKB1 Proteins) signaling pathway in endothelial cells, suggesting that forced Best-3 expression may be a novel approach for the treatment of vascular inflammatory diseases.
identified three novel VMD2 (show BEST1 Proteins)-related human genes demonstrating a high degree of conservation in their respective RFP (show FPR2 Proteins)-TM domains [VMD2L1 (show BEST2 Proteins), VMD2L2 (show BEST4 Proteins), VMD2L3]
These results suggest that an auto-inhibitory mechanism in C termini of bestrophin 3 may be universal among bestrophins investigated in the study.
Our experiments present clear evidence of Best3 mRNA and protein expression in mouse kidney glomeruli
The channel activity of the mBest4 protein lacking the C-terminus (residues 353-669) was specifically inhibited by co-expression of C-terminal fragments of mBest4 having the inhibitory motif.
BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD\; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002
, vitelliform macular dystrophy 2-like 3
, vitelliform macular dystrophy 2-like protein 3