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Bestrophin 3 Proteins (BEST3)

BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD\; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Additionally we are shipping Bestrophin 3 Antibodies (64) and Bestrophin 3 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BEST3 144453 Q8N1M1
BEST3 382427 Q6H1V1
Rat BEST3 BEST3 314847  
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Top Bestrophin 3 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Cow Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

BEST3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
,

More Proteins for Bestrophin 3 (BEST3) Interaction Partners

Human Bestrophin 3 (BEST3) interaction partners

  1. results demonstrated that Best-3 is an endogenous inhibitor of NF-kappaB (show NFKB1 Proteins) signaling pathway in endothelial cells, suggesting that forced Best-3 expression may be a novel approach for the treatment of vascular inflammatory diseases.

  2. identified three novel VMD2 (show BEST1 Proteins)-related human genes demonstrating a high degree of conservation in their respective RFP (show FPR2 Proteins)-TM domains [VMD2L1 (show BEST2 Proteins), VMD2L2 (show BEST4 Proteins), VMD2L3]

  3. These results suggest that an auto-inhibitory mechanism in C termini of bestrophin 3 may be universal among bestrophins investigated in the study.

Mouse (Murine) Bestrophin 3 (BEST3) interaction partners

  1. Our experiments present clear evidence of Best3 mRNA and protein expression in mouse kidney glomeruli

  2. results demonstrated that Best-3 is an endogenous inhibitor of NF-kappaB (show NFKB1 Proteins) signaling pathway in endothelial cells, suggesting that forced Best-3 expression may be a novel approach for the treatment of vascular inflammatory diseases.

  3. The channel activity of the mBest4 protein lacking the C-terminus (residues 353-669) was specifically inhibited by co-expression of C-terminal fragments of mBest4 having the inhibitory motif.

  4. These results suggest that an auto-inhibitory mechanism in C termini of bestrophin 3 may be universal among bestrophins investigated in the study.

Bestrophin 3 (BEST3) Protein Profile

Protein Summary

BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD\; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002

Gene names and symbols associated with Bestrophin 3 Proteins (BEST3)

  • bestrophin 3 (BEST3)
  • Bestrophin 3 (Best3)
  • bestrophin 3 (best3)
  • bestrophin 3 (Best3)
  • best-3 protein
  • BEST3 protein
  • bestrophin-3 protein
  • CG12327 protein
  • dbest3 protein
  • Dmel\\CG12327 protein
  • mBest4 protein
  • Vmd2l3 protein

Protein level used designations for Bestrophin 3 Proteins (BEST3)

bestrophin 3 , CG12327-PA , Best3-PA , bestrophin-3 , bestrophin-3-like , vitelliform macular dystrophy 2-like 3 , vitelliform macular dystrophy 2-like protein 3

GENE ID SPECIES
100052270 Equus caballus
39661 Drosophila melanogaster
100302039 Xenopus (Silurana) tropicalis
100396207 Callithrix jacchus
467066 Pan troglodytes
718450 Macaca mulatta
100453857 Pongo abelii
100484530 Ailuropoda melanoleuca
100607091 Nomascus leucogenys
144453 Homo sapiens
382427 Mus musculus
314847 Rattus norvegicus
417849 Gallus gallus
481158 Canis lupus familiaris
100156203 Sus scrofa
531070 Bos taurus
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