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Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) Proteins (BUB1B)

BUB1B encodes a kinase involved in spindle checkpoint function. Additionally we are shipping BUB1B Antibodies (153) and BUB1B Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BUB1B 701 O60566
Rat BUB1B BUB1B 171576  
BUB1B 12236 Q9Z1S0
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Top BUB1B Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

BUB1B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

More Proteins for Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B) Interaction Partners

Xenopus laevis Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B) interaction partners

  1. Together, our findings demonstrate that Bub1 (show BUB1 Proteins) acts at multiple points to assure the correct kinetochore formation.

Fruit Fly (Drosophila melanogaster) Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B) interaction partners

  1. The Bub3 (show BUB3 Proteins)-BubR1 complex on broken DNA inhibits the APC (show APC Proteins)/C locally via the sequestration of Cdc20 (show CDC20 Proteins).

  2. a model in which Polo controls Mps1-dependent BubR1 phosphorylation to promote Cdc20 (show CDC20 Proteins) kinetochore recruitment and sustained SAC (show ADCY10 Proteins) function.

  3. Data show that the Mad2 (show MAD2L1 Proteins) kinetochore dimerization recruitment mechanism is conserved and that the recruitment of Cdc20 (show CDC20 Proteins) to kinetochores in Drosophila requires BubR1 but not Mad2 (show MAD2L1 Proteins).

  4. Reduced BubR1 or Polo function results in abnormal segregation of acentric chromatids, a decrease in acentric chromosome tethering, and a great reduction in adult survival.

  5. BubR1's role in mitosis is discussed.

  6. BubR1 is required for normal synchrony and progression of syncytial nuclei through mitosis and to maintain the mitotic arrest of the polar body chromosomes after completion of meiosis

  7. BubR1 is required to promote stable microtubule kinetochore attachment. Activation of the mechanism that corrects inappropriate kinetochore attachment requires the antagonistic effects of BubR1 and CENP-E (show CENPE Proteins).

  8. Recruitment of BubR1 by dysfunctional telomeres inhibits Cdc20 (show CDC20 Proteins)-APC (show APC Proteins) function, preventing the metaphase-to-anaphase transition.

Human Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B) interaction partners

  1. We show that kinetochore recruitment of BUBR1 and BUB3 (show BUB3 Proteins) by BUB1 (show BUB1 Proteins) is dispensable for SAC (show ADCY10 Proteins) activation

  2. Data suggest that both BubR1 and SNCG (show SNCG Proteins) may be promising predictive marker rather than prognostic marker in patients with breast cancer.

  3. BubR1 knockdown significantly decreased cellular invasion but slightly affect cellular proliferation on both Ca9 (show CA9 Proteins)-22 and Cal (show FBLIM1 Proteins)-27 cells.

  4. BubR1 contributes to preventing premature aging. [review]

  5. Suggest human papillomavirus E2 protein (show UBE2B Proteins) provokes BUBR1-dependent aneuploidy in HPV-induced cervical cancer.

  6. In conclusion, the results presented here suggest that Mad2 (show MAD2L1 Proteins) and BubR1 could be used as prognostic markers of tumor progression and new pharmacological targets in the treatment for gastric cancer .

  7. Co-depletion of MAD2 (show MAD2L1 Proteins) and BUBR1 causes cell cycle arrest and cell death in addition to aneuploidy.

  8. By sequestering PIDD at the kinetochore, BubR1 acts to delay PIDDosome formation until the next cycle, defining a new mechanism by which cells evade apoptosis during mitosis.

  9. a Cdc20 (show CDC20 Proteins) binding site in BubR1 facilitates both spindle assembly checkpoint signalling and silencing

  10. study shows that SIRT2 (show SIRT2 Proteins) is a deacetylase for BubR1 K250, although the abnormally prolonged SAC (show ADCY10 Proteins) activation observed in SIRT2 (show SIRT2 Proteins) knockdown cells is not accompanied by a change in BubR1 levels or by delayed progression from prometaphase to anaphase

Mouse (Murine) Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B) interaction partners

  1. Data show that compound mutant spindle assembly checkpoint components BubR1 and Sgo1 (show SGOL1 Proteins) embryonic fibroblasts (MEFs) grew at a much slower rate, and a small fraction of cells exhibited morphologies of senescent cells at early passages.

  2. These data reveal that BubR1 plays a multifaceted role in chromosome segregation during the first meiotic division and suggest that age-related decline of BubR1 is a key determinant of the formation of aneuploid oocytes during aging.

  3. BubR1 (-/-) embryos were aneuploid and had an increased level of premature sister chromatid separation.

  4. Low BubR1 expression almost completely inhibited intimal hyperplasia after carotid ligation by suppressing the proliferation of VSMCs, which was caused, in part, by delayed cell cycle progression.

  5. the loss of BubR1 levels with age is due to a decline in NAD(+) and the ability of SIRT2 (show SIRT2 Proteins) to maintain lysine-668 of BubR1 in a deacetylated state, which is counteracted by the acetyltransferase CBP (show CREBBP Proteins).

  6. BubR1 insufficiency elicits an aging response that is counteracted by p53 (show TP53 Proteins) and involves single or multiple p53 (show TP53 Proteins) targets, depending on the tissue type.

  7. BubR1 acetylation is essential for embryonic development.

  8. these data demonstrate that the BUBR1 GTTA mutation compromises longevity and healthspan, raising the interesting possibility that mono-allelic changes in BUBR1 might contribute to differences in aging rates in the general population.

  9. Hhigh-level expression of BubR1 extends lifespan and delays age-related deterioration and aneuploidy in several tissues.

  10. BubR1 is a spindle assembly checkpoint protein regulating meiotic progression of oocytes.

BUB1B Protein Profile

Protein Summary

This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.

Gene names and symbols associated with BUB1B

  • BUB1 mitotic checkpoint serine/threonine kinase B (bub1b)
  • budding uninhibited by benzimidazoles 1 homolog beta (yeast) (BUB1B)
  • Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (bub1b)
  • Bub1 homologue (Bub1)
  • Bub1-related kinase (BubR1)
  • BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B)
  • BUB1 mitotic checkpoint serine/threonine kinase B (Bub1b)
  • budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) (Bub1b)
  • 31/13 protein
  • AU045529 protein
  • BcDNA:LD23835 protein
  • Bub1 protein
  • BUB1-like protein
  • Bub1A protein
  • bub1b protein
  • BUB1beta protein
  • bubr1 protein
  • BubRI protein
  • CG7838 protein
  • CG 7838 protein
  • CG14030 protein
  • CG14030/Bub1 protein
  • dBUB1 protein
  • Dmbub1 protein
  • Dmel\\CG7838 protein
  • Dmel\\CG14030 protein
  • hBUBR1 protein
  • l(2)k03113 protein
  • l(2)k06109 protein
  • MAD3L protein
  • mcl(2)Z1525 protein
  • MVA1 protein
  • SSK1 protein

Protein level used designations for BUB1B

BUB1 budding uninhibited by benzimidazoles 1 homolog beta , budding uninhibited by benzimidazoles 1 beta , budding uninhibited by benzimidazoles 1 homolog beta , mitotic checkpoint serine/threonine-protein kinase BUB1 beta , budding uninhibited by benzimidazoles 1 homolog beta (yeast) , mitotic checkpoint serine/threonine-protein kinase BUB1 beta-like , Bub1-PA , CG14030-PA , Bub1 , BubR1-PA , CG7838-PA , bub related one , mcl(2)Z1525 , MAD3/BUB1-related protein kinase , mitotic checkpoint kinase MAD3L , budding uninhibited by benzimidazoles 1 homolog, beta

GENE ID SPECIES
378923 Xenopus laevis
453324 Pan troglodytes
537027 Bos taurus
100125106 Xenopus (Silurana) tropicalis
100196482 Salmo salar
100413586 Callithrix jacchus
100423079 Macaca mulatta
100455824 Pongo abelii
100464546 Ailuropoda melanoleuca
100607252 Nomascus leucogenys
100629735 Equus caballus
33758 Drosophila melanogaster
35522 Drosophila melanogaster
378922 Gallus gallus
701 Homo sapiens
171576 Rattus norvegicus
608350 Canis lupus familiaris
12236 Mus musculus
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