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Negative regulator of T-cell proliferation.. Additionally we are shipping BTNL2 Antibodies (6) and BTNL2 Kits (3) and many more products for this protein.
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Butyrophilin-like 2 modulates B7 costimulation to induce Foxp3 (show FOXP3 Proteins) expression and regulatory T cell development in mature T cells.
BTNL2 is overexpressed during both the asymptomatic and symptomatic phase of the Mdr1a (show ABCB4 Proteins) knockout model of spontaneous colitis. Soluble BTNL2-Fc protein inhibits proliferation of murine T4 cells from the spleen, mesenteric lymph node, and Peyer's patch.
BTNL2 G16071A gene polymorphism may as a likelihood factor contributed to granulomatous disease susceptibility, especially increasing the sarcoidosis susceptibility. In addition, the polymorphism may be greatly associated with likelihood of granulomatous diseases among Caucasians.
BTNL2 may have an inhibitory effect on FOXP3 (show FOXP3 Proteins)(+) T cell proliferation, especially in patients homozygous for the risk alleles.
genetic mutations within or around BTNL2 (rs3763313, rs9268494, rs9268492 and rs9268402) could alter susceptibility to grade IV of dilated cardiomyopathy in a Chinese population
Results confirm the association of BTNL2 rs2076530SNP with the susceptibility to develop sarcoidosis, but not with an increased risk of cancer in these patients.
BTNL2 rs2076530 polymorphism contributes to the risk of sarcoidosis
Two independent loci near BTNL2 (rs9461741) and HLA-B (rs2922994) in the HLA region significantly associated with Marginal Zone B-Cell Lymphoma risk.
The association of the rare variant p.G454C in BTNL2 reached genome-wide significance, and was independent of the known common risk variants for IBD in the HLA region in both a conditional and haplotype analysis
These findings suggest that polymorphisms in the BTNL2 gene might play a vital role in determining the outcome of the immune response to hepatitis B vaccination.
No variation except in the 329-bp region containing the BTNL2 rs2076530 polymorphism was found in Turkish patients with sarcoidosis.
Rare BTNL2 variants play a role in susceptibility to both familial and sporadic prostate cancer. Results implicate BTNL2 as a novel prostate cancer susceptibility gene.
Negative regulator of T-cell proliferation.
butyrophilin-like protein 2
, butyrophilin-like 2 (MHC class II associated)
, butyrophilin-like protein 2-like
, butyrophylin-like MHC class II associated