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CLEC7A encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Additionally we are shipping CLEC7A Kits (22) and CLEC7A Proteins (14) and many more products for this protein.
Showing 10 out of 217 products:
Mouse (Murine) Monoclonal CLEC7A Primary Antibody for Func, FACS - ABIN181895
Reid, Montoya, Taylor, Borrow, Gordon, Brown, Wong: Expression of the beta-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions. in Journal of leukocyte biology 2004
Show all 7 references for ABIN181895
Human Monoclonal CLEC7A Primary Antibody for FACS - ABIN4897736
Cunha, Di Ianni, Bozza, Giovannini, Zagarella, Zelante, DAngelo, Pierini, Pitzurra, Falzetti, Carotti, Perruccio, Latgé, Rodrigues, Velardi, Aversa, Romani, Carvalho et al.: Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of ... in Blood 2010
Show all 6 references for ABIN4897736
Mouse (Murine) Monoclonal CLEC7A Primary Antibody for FACS - ABIN320108
Brown, Taylor, Reid, Willment, Williams, Martinez-Pomares, Wong, Gordon: Dectin-1 is a major beta-glucan receptor on macrophages. in The Journal of experimental medicine 2002
Show all 4 references for ABIN320108
Human Polyclonal CLEC7A Primary Antibody for EIA, IF - ABIN1449932
Kerrigan, Brown: Syk-coupled C-type lectin receptors that mediate cellular activation via single tyrosine based activation motifs. in Immunological reviews 2010
Show all 4 references for ABIN1449932
Mouse (Murine) Monoclonal CLEC7A Primary Antibody for FACS, IHC (fro) - ABIN181896
Taylor, Brown, Reid, Willment, Martinez-Pomares, Gordon, Wong: The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages. in Journal of immunology (Baltimore, Md. : 1950) 2002
Show all 4 references for ABIN181896
Mouse (Murine) Monoclonal CLEC7A Primary Antibody for FACS - ABIN181893
Underhill, Rossnagle, Lowell, Simmons: Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production. in Blood 2005
Show all 2 references for ABIN181893
Human Monoclonal CLEC7A Primary Antibody for FACS - ABIN4897732
Sindrilaru, Peters, Wieschalka, Baican, Baican, Peter, Hainzl, Schatz, Qi, Schlecht, Weiss, Wlaschek, Sunderkötter, Scharffetter-Kochanek: An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice. in The Journal of clinical investigation 2011
Mouse (Murine) Monoclonal CLEC7A Primary Antibody for FACS - ABIN4897760
Xu, Huo, Gunawan, Su, Lam: Activated dectin-1 localizes to lipid raft microdomains for signaling and activation of phagocytosis and cytokine production in dendritic cells. in The Journal of biological chemistry 2009
These results suggest that functionally neutral polymorphisms in dectin-1 are widespread in pig populations
recognition of beta-glucans appeared cell type-specific as both dectin-1 and CR3 (show ITGAM Antibodies) are involved in the beta-glucan-mediated responses in pig macrophages.
CD4 (show CD4 Antibodies)(+) T-cell survival in the gastrointestinal tract tract requires dectin-1 during Canida infection.
Our present study suggested that Dectin-1 is a novel receptor for Trichosporon asahii and demonstrates the critical role of Dectin-1 in the development of T. asahii-induced hypersensitivity pneumonitis.
Mast cells are able to phagocytose and produce nitric oxide against Candida albicans via TLR2 (show TLR2 Antibodies)/Dectin-1.
TREM-1 (show TREM1 Antibodies) and Dectin-1 function concurrently in the corneal innate immune response by regulating inflammatory cytokine expression in fungal keratitis.
Sc CW-derived BG stimulated the late and strong expression of Csf2 (show CSF2 Antibodies) in a dectin-1-dependent manner, they remain poor inducers of chemokine (show CCL1 Antibodies) and cytokine production in murine macrophages.
recognition of beta-1,3 glucan by Dectin-1 triggers TLR9 (show TLR9 Antibodies) trafficking to beta-1,3 glucan-containing phagosomes, which may be critical in coordinating innate antifungal defense.
These observations suggest that Dectin-1 regulates the homeostasis of intestinal immunity by controlling Treg cell differentiation through modification of microbiota.
our findings define the mechanism of receptor crosstalk between CR3 (show ITGAM Antibodies) and Dectin-1 and demonstrate the importance of their collaboration in host defense against fungal infection.
Findings indicate a role for inositol-polyphosphate 5-phosphatase SHIP-1 coupling to DC-type lectin receptor ectin-1 hemITAM in the selective control of downstream responses.
Dectin-1 Activation by a Natural Product beta-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype.
study represents the first analysis demonstrating that harbouring polymorphisms of Dectin-1 (rs7309123) or TLR2 (show TLR2 Antibodies) (rs5743708) represents an independent risk factor of developing IFD in patients with AML (show RUNX1 Antibodies) undergoing induction chemotherapy.
Our data suggest that the genetic diversity of CLEC7A gene influences the autism spectrum disorders (ASD (show ARSD Antibodies)) phenotype by behaving as a disease specifier and imply that the genetic control of innate immune response could determine the ASD (show ARSD Antibodies) phenotype.
The result of this study suggests that there is no correlation between Dectin-1 Y238X Gene polymorphism and RVVC.
This study demonstrated that Toll (show TLR4 Antibodies)-Like Receptors and Dectin-1, a C-Type Lectin Receptor (show CLEC4D Antibodies), Trigger Divergent Functions in CNS Macrophages.
Data indicate that Candida albicans beta-Glucan induces high IL-1 (show IL1A Antibodies) receptor antagonist (IL-1Ra (show IL1RN Antibodies)) levels, independently from Dectin-1/complement receptor 3 (CR3 (show ITGAM Antibodies)).
The analysis of Dectin-1 gene polymorphisms showed no significant association with fungal keratitis in the northern Han Chinese population.
Dectin-1 expressed on human pulmonary epithelial cells has a considerable impact on the Nontypeable Haemophilus influenzae triggered immune response.
The superoxide induction with whole glucan particle was concluded to be Dectin-1-mediated and required Src (show SRC Antibodies) family kinases, phosphatidylinositol-3 kinase and protein kinase B/Akt (show AKT1 Antibodies).
CARD9 (show CARD9 Antibodies) regulates H-Ras (show HRAS Antibodies) activation by linking Ras-GRF1 (show RASGRF1 Antibodies) to H-Ras (show HRAS Antibodies), which mediates Dectin-1-induced extracellular signal-regulated protein kinase (show CDK7 Antibodies) (ERK (show EPHB2 Antibodies)) activation and proinflammatory responses when stimulated by their ligands.
CLEC7a genetic variant c.589A>G was significantly associated (p = 0.008) with Mycobacterium avium ssp. paratuberculosis infection in Holsteins cattle.
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
dendritic cell-associated C-type lectin 1
, C-type lectin domain family 7, member A
, C-type lectin domain family 7 member A
, dectin 1
, C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12
, C-type lectin superfamily member 12
, DC-associated C-type lectin 1
, beta-glucan receptor
, C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12
, dendritic cell-associated C-type lectin-1
, lectin-like receptor 1