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The protein encoded by CD163 is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. Additionally we are shipping CD163 Antibodies (412) and CD163 Kits (37) and many more products for this protein.
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During ischaemia, soluble CD163 functions as a decoy receptor for TWEAK (show TNFSF12 Proteins), to regulate TWEAK (show TNFSF12 Proteins)-induced activation of canonical nuclear factor-kappaB and Notch (show NOTCH1 Proteins) signalling necessary for myogenic progenitor cell proliferation.
Data indicate an essential substrate motif for ADAM17 (show ADAM17 Proteins)-mediated CD163 and proTNF-alpha cleavage in macrophages.
alpha(1)-Acid glycoprotein (show ORM1 Proteins) up-regulates CD163 via TLR4 (show TLR4 Proteins)/CD14 protein (show ERGIC2 Proteins) pathway: possible protection against hemolysis-induced oxidative stress.
Data show that telmisartan reduced the mRNA expression of CD11c (show ITGAX Proteins) and TNF-alpha (show TNF Proteins), M1 macrophage markers, and significantly increased the expressions of M2 markers, such as CD163, CD209 (show CD209 Proteins).
Assignment of the CD163 antigen to mouse chromosome 6 band F2.
Heart failure with reduced ejection fraction (HF-REF (show THOC4 Proteins)) patients present increased sTWEAK and sCD163 levels as well as sTWEAK/sCD163 ratio when compared to healthy subjects, however CHF itself appears to be associated with down-regulation of sTWEAK.
we have developed a highly sensitive targeted probe capable of detecting CD163-expressing macrophages that could provide useful information about the state of the atheromatous lesions.
A subset of CD163+ macrophages displays mixed polarizations in discoid lupus skin.
Increased soluble CD163 blood levels in hepatocellular carcinoma patients correlates with rapid hepatocellular carcinoma progression.
these data indicate that sCD163 is a prognostic marker in B-CLL.
sCD163 is a sensitive marker protein for liver failure.
CD163-positive macrophages predict outcome in follicular lymphoma, but their prognostic impact is highly dependent on treatment received.
therapy with rituximab, cyclophosphamide and fludarabine resulted in a significant reduction in the number of non-classical CD14 (show NDUFA2 Proteins)+CD16 (show CD16 Proteins)++ monocytes and soluble form of CD163 but upregulation of membrane-associated monocyte CD163
Renal graft CD163+ infiltrates correlated strongly with interstitial inflammation, tubulitis, and peritubular capillaritis.
Higher levels of circulating monocyte-platelet aggregates are correlated with viremia and increased sCD163 levels in HIV-1 infection.
CD163 represents an additional candidate gene for resistance against porcine reproductive and respiratory syndrome.
Overexpression of ADAM17 (show ADAM17 Proteins) induced downregulation of CD163 expression and a reduction in reproductive and respiratory syndrome virus infection.
Fusion protein of sialoadhesin (show SIGLEC1 Proteins) and domains 5-9 of CD163 receptors blocked the respiratory syndrome virus infection.
GP4 (show CD36 Proteins) is involved in interaction with cellular receptor CD163.
). These results provided fundamental evidence for CD163 and SN as two functional candidate genes affecting immunity in pigs.
Porcine reproductive and respiratory syndrome virus GP4 (show CD36 Proteins) was found to co-localize with CD163 in the lipid rafts on the plasma membrane.
Our results suggest that the intracellular domain of CD163 may be associated with an important yet-unknown function during porcine reproductive and respiratory syndrome virus replication.
The newly established porcine alveolar macrophage cell lines were demonstrated to express robust levels of CD163 and to be fully permissive for both type 1 and 2 porcine reproductive and respiratory syndrome virus strains.
The carboxy-terminal 223 residues of the CD163 molecule are not required for interactions with either the GP2a or the GP4 (show CD36 Proteins) protein, although these residues are required for conferring susceptibility to PRRSV infection.
CD163 is shown to be involved in PRRSV (porcine reproductive and respiratory syndrome virus) entry, probably during uncoating, and to interact with sialoadhesin (show SIGLEC1 Proteins) in the process.
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
, CD163 molecule
, scavenger receptor cysteine-rich type 1 protein M130-like
, scavenger receptor cysteine-rich type 1 protein M130
, hemoglobin scavenger receptor
, macrophage-associated antigen