CD163 Molecule Proteins (CD163)

The protein encoded by CD163 is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. Additionally we are shipping CD163 Antibodies (426) and CD163 Kits (61) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CD163 93671 Q2VLH6
CD163 312701  
CD163 9332 Q86VB7
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Top CD163 Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$12,127.90
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 70 to 75 Days
$9,912.25
Details
Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 13 to 16 Days
$768.00
Details
Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$816.00
Details
HEK-293 Cells Human His tag   100 μg Log in to see 2 to 3 Days
$618.75
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$860.20
Details
Escherichia coli (E. coli) Pig His tag   50 μg Log in to see 2 to 3 Days
$190.93
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
HEK-293 Cells Human His tag   10 μg Log in to see 2 to 3 Days
$220.00
Details
HEK-293 Cells Human His tag Human CD163, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Log in to see 2 to 3 Days
$385.00
Details

CD163 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
, ,
Rat (Rattus)

Human , , ,
, , ,

More Proteins for CD163 Molecule (CD163) Interaction Partners

Mouse (Murine) CD163 Molecule (CD163) interaction partners

  1. house dust mite -challenged Cd163-/- mice displayed increases in airway eosinophils and mucous cell metaplasia

  2. In diabetic mice, increased sCD163 at wk 5 and decreased percentage of CD163(+) monocytes at wk 10 preceded alteration in kidney collagen IV mRNA at wk 20. In vitro incubation of monocytes in anti-inflammatory glucocorticoid increased the percentage of CD163(+) monocytes.

  3. During ischaemia, soluble CD163 functions as a decoy receptor for TWEAK (show TNFSF12 Proteins), to regulate TWEAK (show TNFSF12 Proteins)-induced activation of canonical nuclear factor-kappaB and Notch (show NOTCH1 Proteins) signalling necessary for myogenic progenitor cell proliferation.

  4. Data indicate an essential substrate motif for ADAM17 (show ADAM17 Proteins)-mediated CD163 and proTNF-alpha cleavage in macrophages.

  5. alpha(1)-Acid glycoprotein (show ORM1 Proteins) up-regulates CD163 via TLR4 (show TLR4 Proteins)/CD14 protein (show ERGIC2 Proteins) pathway: possible protection against hemolysis-induced oxidative stress.

  6. Data show that telmisartan reduced the mRNA expression of CD11c (show ITGAX Proteins) and TNF-alpha (show TNF Proteins), M1 macrophage markers, and significantly increased the expressions of M2 markers, such as CD163, CD209 (show CD209 Proteins).

  7. Assignment of the CD163 antigen to mouse chromosome 6 band F2.

Human CD163 Molecule (CD163) interaction partners

  1. Although sCD163 level cannot predict the development of varices, it serves as a good predictor for the detection of size of varices (large varices), the need of prophylactic interventions, and risk of variceal bleeding. sCD163 level is a helpful indicator with the progression of cirrhosis and portal hypertension.

  2. CD163 and ferritin (show FTL Proteins) are biomarkers of functional outcomes in intracerebral hemorrhage.

  3. the simultaneous detection of both plasma sCD14 and IL-6 (show IL6 Proteins) is a promising diagnostic approach to identify active pulmonary tuberculosis, and further, measurement of TNF-alpha (show TNF Proteins) and sCD163 can identify the most severe cases of tuberculosis.

  4. The macrophage activation marker CD163 was increased in patients with active pulmonary TB compared with age- and sex-matched control subjects.

  5. alveolar macrophages from asthmatic subjects have reduced cell-surface expression of CD163, which suggests that CD163 might modulate the pathogenesis of asthma

  6. Serum sCD163 might be a potential biomarker for predicting the severity and prognosis of PM/DM-related interstitial lung disease

  7. Soluble CD163 reflecting macrophage activation is associated with morphological features of non-alcoholic fatty liver disease. An independent association between sCD163 and cytokeratin-18 (show KRT18 Proteins) suggests that apoptosis may contribute to macrophage activation in NAFLD/NASH (show SAMSN1 Proteins).

  8. Most cases of histiocytic sarcoma expressed histiocytic markers CD68 (show CD68 Proteins) (6 of 7 cases), CD163 (5 of 5 cases), and PU.1 (3 of 4 cases).

  9. Within a diabetic cohort, the percentage of monocytes expressing CD163 was decreased in those subjects with complications, compared to those without complications. These changes were not accompanied by a change in gene expression. Glucocorticoids increased CD163 expression in cultured peripheral blood monocytes from non-diabetic persons.

  10. sCD163 was markedly elevated in autoimmune hepatitis (AIH) in the acute phase, normalised by successful treatment in complete responders, but remained higher in the incompletely responding cases. Our results demonstrate macrophage activation in AIH paralleling disease activity, severity and treatment response, suggesting a role for macrophage activation in AIH.

Pig (Porcine) CD163 Molecule (CD163) interaction partners

  1. deletion of Exon 7 of the CD163 gene, encoding SRCR5 had no adverse effects in pigs and these animals showed complete resistance to viral infection by the positive-strand RNA PRRS virus

  2. CD163 is not necessary for infection with African swine fever virus.

  3. CD163 represents an additional candidate gene for resistance against porcine reproductive and respiratory syndrome.

  4. Overexpression of ADAM17 (show ADAM17 Proteins) induced downregulation of CD163 expression and a reduction in reproductive and respiratory syndrome virus infection.

  5. Fusion protein of sialoadhesin (show SIGLEC1 Proteins) and domains 5-9 of CD163 receptors blocked the respiratory syndrome virus infection.

  6. GP4 (show CD36 Proteins) is involved in interaction with cellular receptor CD163.

  7. ). These results provided fundamental evidence for CD163 and SN as two functional candidate genes affecting immunity in pigs.

  8. Porcine reproductive and respiratory syndrome virus GP4 (show CD36 Proteins) was found to co-localize with CD163 in the lipid rafts on the plasma membrane.

  9. Our results suggest that the intracellular domain of CD163 may be associated with an important yet-unknown function during porcine reproductive and respiratory syndrome virus replication.

  10. The newly established porcine alveolar macrophage cell lines were demonstrated to express robust levels of CD163 and to be fully permissive for both type 1 and 2 porcine reproductive and respiratory syndrome virus strains.

CD163 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with CD163 Molecule Proteins (CD163)

  • deleted in malignant brain tumors 1 protein-like (LOC426820)
  • CD163 molecule (CD163)
  • CD163 antigen (Cd163)
  • CD163 molecule (Cd163)
  • CD163 protein
  • CD163v2 protein
  • CD163v3 protein
  • DMBT1 protein
  • M130 protein
  • MM130 protein

Protein level used designations for CD163 Molecule Proteins (CD163)

CD163 antigen , CD163 molecule , scavenger receptor cysteine-rich type 1 protein M130-like , scavenger receptor cysteine-rich type 1 protein M130 , hemoglobin scavenger receptor , macrophage-associated antigen , CD163v2 , CD163v3

GENE ID SPECIES
426820 Gallus gallus
451815 Pan troglodytes
100393445 Callithrix jacchus
100605146 Nomascus leucogenys
93671 Mus musculus
312701 Rattus norvegicus
9332 Homo sapiens
397031 Sus scrofa
533844 Bos taurus
477704 Canis lupus familiaris
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