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NB1, a glycosyl-phosphatidylinositol (GPI)-linked N-glycosylated cell surface glycoprotein, was first described in a case of neonatal alloimmune neutropenia (Lalezari et al., 1971 [PubMed 5552408]).[supplied by OMIM, Mar 2008].. Additionally we are shipping CD177 Proteins (11) and CD177 Kits (7) and many more products for this protein.
Showing 10 out of 136 products:
Human Monoclonal CD177 Primary Antibody for FACS, IP - ABIN119765
Dillon, Minear, Johnson, Lannutti: Expression of the GPI-anchored receptor Prv-1 enhances thrombopoietin and IL-3-induced proliferation in hematopoietic cell lines. in Leukemia research 2008
Show all 10 references for ABIN119765
Human Monoclonal CD177 Primary Antibody for FACS - ABIN2661536
Lalezari, Murphy, Allen: NB1, a new neutrophil-specific antigen involved in the pathogenesis of neonatal neutropenia. in The Journal of clinical investigation 1971
Show all 6 references for ABIN2661536
Human Monoclonal CD177 Primary Antibody for FACS, IHC - ABIN2662479
Temerinac, Klippel, Strunck, Röder, Lübbert, Lange, Azemar, Meinhardt, Schaefer, Pahl: Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera. in Blood 2000
Show all 6 references for ABIN2662479
Human Monoclonal CD177 Primary Antibody for FACS, IP - ABIN94001
Korkmaz, Kuhl, Bayat, Santoso, Jenne: A hydrophobic patch on proteinase 3, the target of autoantibodies in Wegener granulomatosis, mediates membrane binding via NB1 receptors. in The Journal of biological chemistry 2008
Show all 4 references for ABIN94001
Human Monoclonal CD177 Primary Antibody for FACS, IP - ABIN119768
Bauer, Abdgawad, Gunnarsson, Segelmark, Tapper, Hellmark: Proteinase 3 and CD177 are expressed on the plasma membrane of the same subset of neutrophils. in Journal of leukocyte biology 2007
Show all 4 references for ABIN119768
Human Polyclonal CD177 Primary Antibody for IF (p), IHC (p) - ABIN687187
Li, Li, Sanders, Mohler, Backs, Olson, Anderson, Grumbach et al.: The multifunctional Ca2+/calmodulin-dependent kinase II delta (CaMKIIdelta) controls neointima formation after carotid ligation and vascular smooth muscle cell proliferation through cell cycle ... in The Journal of biological chemistry 2011
Show all 3 references for ABIN687187
Human Monoclonal CD177 Primary Antibody for FACS - ABIN119766
Kissel, Scheffler, Kerowgan, Bux: Molecular basis of NB1 (HNA-2a, CD177) deficiency. in Blood 2002
Show all 2 references for ABIN119766
Human Monoclonal CD177 Primary Antibody for FACS - ABIN119767
Caruccio, Bettinotti, Matsuo, Sharon, Stroncek: Expression of human neutrophil antigen-2a (NB1) is increased in pregnancy. in Transfusion 2003
Show all 2 references for ABIN119767
Human Polyclonal CD177 Primary Antibody for FACS, WB - ABIN4899677
Jerke, Rolle, Dittmar, Bayat, Santoso, Sporbert, Luft, Kettritz: Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation. in The Journal of biological chemistry 2011
Abundance of CD177hi neutrophils correlates with homozygosity for CD177 reference allele, while heterozygosity for ectopic CD177P1 gene conversion correlates with increased CD177neg neutrophils, in which both CD177P1 partially incorporated allele and paired intact CD177 allele are transcribed
Data indicate that high percentage of CD177 antigen-positive neutrophils undergo dynamic change during sepsis.
the CD177 SNP is the primary genetic determinant for HNA-2 deficiency and expression variations. The mechanistic delineation of HNA-2 genetics will enable the development of genetic tests for diagnosis and prognosis of HNA-2-related human diseases.
This is the first report showing a prognostic correlation between CD177 expression and solid tumor behavior.
Skewed low neutrophil CD177(%) is highly associated with clonal myeloid disorders, particularly myelodysplasia, and may be useful for detecting clonal myeloid disorders.
CD177/PECAM-1 (show PECAM1 Antibodies) adhesive interaction, while contributing to neutrophil-endothelial cell interaction in neutrophil transendothelial migration, does not contribute to or is redundant in platelet-neutrophil interactions
PRV1 overexpression is associated with Essential Thrombocythemia and Myelofibrosis.
NB1-proteinase 3 (show PRTN3 Antibodies) interactions may play a role in aiding neutrophil transmigration.
pivotal role of the NB1-Mac-1 receptor interaction for PR3-ANCA-mediated neutrophil activation
The increased membrane expression of PR3 (show PRTN3 Antibodies) found in ANCA-associated systemic vasculitis is not linked directly to circulating PR3 (show PRTN3 Antibodies) or PR3 (show PRTN3 Antibodies) gene transcription, but is dependent upon CD177 expression and correlated with the transcription of the CD177 gene.
Herein we established a novel genetic mouse model to study the role of CD177 and found that CD177 plays an important role in neutrophils.
NB1, a glycosyl-phosphatidylinositol (GPI)-linked N-glycosylated cell surface glycoprotein, was first described in a case of neonatal alloimmune neutropenia (Lalezari et al., 1971
, CD177 molecule
, CD177 antigen-like
, NB1 glycoprotein
, cell surface receptor
, human neutrophil alloantigen 2a
, polycythemia rubra vera 1
, polycythemia rubra vera protein 1