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CD47 encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. Additionally we are shipping CD47 Antibodies (278) and CD47 Kits (7) and many more products for this protein.
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Human CD47 Protein expressed in HEK-293 Cells - ABIN2180804
Piccio, Vermi, Boles, Fuchs, Strader, Facchetti, Cella, Colonna: Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation. in Blood 2005
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atherogenesis is associated with upregulation of CD47, a key anti-phagocytic molecule that is known to render malignant cells resistant to programmed cell removal, or 'efferocytosis'
Erythrocyte CD47 has a key role in hematoma clearance after intracerebral hemorrhage.
These data indicate that CD47 plays protective roles against disseminated candidiasis and alters pro-inflammatory and immunosuppressive pathways known to regulate innate and T cell immunity.
CD47 deficiency ameliorates lupus nephritis in Fas(lpr (show FAS Proteins)) mice via suppression of IgG autoantibody production.
the cell adhesion molecule (show MCAM Proteins) CD47 participates in multiple phases of granule cell development, including proliferation, migration, and neurite differentiation
CD47 mediates signaling from the extracellular matrix that coordinately regulates basal metabolism and cytoprotective responses to radiation injury
Taken together, these data revealed a novel role for CD47 in the development of obesity and its related metabolic complications.
NF KB mediated CD47 up regulation promotes sorafenib resistance treating hepatocellular carcinoma.
Loss of cell surface CD47 clustering formation and binding avidity to SIRPalpha facilitate apoptotic cell clearance by macrophages.
findings prove that the TSP-1 (show GZMA Proteins)/CD47/SIRP (show SIRPA Proteins)-alpha signal axis is important to the evolution of tumor cells in the microenvironment of immunotherapy and identify thrombospondin-1 (show THBS1 Proteins) as a key signal
Data show that anti-human CD47 antibody B6H12 decreased expression of epidermal growth factor receptor (EGFR (show EGFR Proteins)) and the stem cell transcription factors.
suggest that microglial activation may be partially caused by CD47/signal regulatory protein-alpha (show SIRPA Proteins)- and CD200 (show CD200 Proteins)/CD200R (show CD200R1 Proteins)-mediated reductions in the immune inhibitory pathways
Our results highlight an underappreciated contribution of the adaptive immune system to anti-CD47 adjuvant therapy and suggest that targeting both innate and adaptive immune checkpoints can potentiate the vaccinal effect of antitumor antibody therapy.
Data suggest a reduction in the CD47 antigen/signal-regulatory protein alpha (show SIRPA Proteins) (SIRPalpha) pathway by programmed cell death protein 1 (PD-1 (show PDCD1 Proteins)) blockade, which regulates Myeloid-derived suppressor cells (MDSCs) and tumor associated macrophages (TAMs).
CD47 is a critical regulator in the metastasis of osteosarcoma and results suggest that targeted inhibition of this antigen by anti-CD47 may be a novel immunotherapeutic approach in the management of this tumor.
agents that block the CD47:SIRP (show SIRPA Proteins)-alpha engagement are attractive therapeutic targets as a monotherapy or in combination with additional immune-modulating agents for activating antitumor T cells in vivo
CD47 is an adverse prognostic factor and promising therapeutic target in gastric cancer.
study demonstrates that antigen-presenting cells(CD47+) in coculture with human macrophages show a CD47 concentration-dependent inhibition of phagocytosis
CD47 expression contributes to the lethal breast cancer phenotype that is mediated by HIF-1 (show HIF1A Proteins).
Amyloid-beta inhibits No-cGMP signaling in a CD36 (show CD36 Proteins)- and CD47-dependent manner
Genetic induction of human CD47 on porcine cells could provide inhibitory signaling to SIRPalpha on human macrophages, providing a novel approach to preventing macrophage-mediated xenograft rejection.
This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene.
, integrin-associated protein
, leukocyte surface antigen CD47
, CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
, CD47 glycoprotein
, antigen identified by monoclonal antibody 1D8
, antigenic surface determinant protein OA3
, integrin associated protein
, integrin-associated signal transducer
, CD47 antigen