CD68 Molecule Proteins (CD68)

CD68 encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. Additionally we are shipping CD68 Antibodies (630) and CD68 Kits (31) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CD68 12514 P31996
CD68 287435  
CD68 968 P34810
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Top CD68 Proteins at antibodies-online.com

Showing 10 out of 33 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human Fc Tag Human CD68, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Log in to see 11 Days
$275.00
Details
HOST_Human Cells Human Fc Tag,His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Human Cells Rat His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 2 to 3 Days
$375.00
Details
HOST_Baculovirus infected Insect Cells Human His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 15 to 19 Days
$407.00
Details
HOST_HEK-293 Cells Human Fc Tag The purity of Human CD68 Fc Tag was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue. 50 μg Log in to see 2 to 3 Days
$715.00
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 15 to 18 Days
$800.00
Details

CD68 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , ,
, , ,
Rat (Rattus) ,
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Human , , , , , ,
, , , ,

Top referenced CD68 Proteins

  1. Human CD68 Protein expressed in HEK-293 Cells - ABIN2180823 : Kunisch, Fuhrmann, Roth, Winter, Lungershausen, Kinne: Macrophage specificity of three anti-CD68 monoclonal antibodies (KP1, EBM11, and PGM1) widely used for immunohistochemistry and flow cytometry. in Annals of the rheumatic diseases 2004 (PubMed)
    Show all 4 references for 2180823

  2. Human CD68 Protein expressed in Escherichia coli (E. coli) - ABIN1098674 : Shun, Yeh, Chang, Wu, Lien, Chen, Wang, Chia: Activation of human valve interstitial cells by a viridians streptococci modulin induces chemotaxis of mononuclear cells. in The Journal of infectious diseases 2009 (PubMed)
    Show all 2 references for 1098674

  3. Rat (Rattus) CD68 Protein expressed in Human Cells - ABIN2009458 : Sadovnikova, Parovichnikova, Savchenko, Zabotina, Stauss: The CD68 protein as a potential target for leukaemia-reactive CTL. in Leukemia 2002 (PubMed)
    Show all 2 references for 2009458

  4. Human CD68 Protein expressed in Human Cells - ABIN2004070 : Strojnik, Kavalar, Zajc, Diamandis, Oikonomopoulou, Lah: Prognostic impact of CD68 and kallikrein 6 in human glioma. in Anticancer research 2009 (PubMed)
    Show all 2 references for 2004070

More Proteins for CD68 Molecule (CD68) Interaction Partners

Mouse (Murine) CD68 Molecule (CD68) interaction partners

  1. Findings indicate that human CD68 and its mouse ortholog macrosialin located in the lysosomal membrane and share many structural similarities.

  2. Myeloid osteoclast precursors do not express CD68.

  3. CD68, a putative receptor for sporozoite invasion of Kupffer cells that acts as a gateway for malaria infection of the liver.

  4. Results showed that activated microglia in Alzheimer's disease-like mice showed two-step transition: a CD68-negative activated form at 6-9 months and a CD68-positive form from 12 months of age

  5. Statins promote the beneficial remodeling of plaques in diseased mouse arteries through the stimulation of the CCR7 (show CCR7 Proteins) / CD68 emigration pathway in macrophages

  6. These findings demonstrate a role for CD68 in the function of osteoclasts.

  7. CD68-null mononuclear phagocytes exhibited a trend toward enhanced antigen presentation to CD4+ T cells, indicating that CD68 may function to negatively regulate antigen uptake, loading, or major histocompatibility complex class II trafficking.

  8. Atherogenic diet-induced reduction in lipid levels of Reversa model mouse leads to decreased monocyte-derived CD68-positive cells in advanced atherosclerotic plaques and is associated with emigration of these cells from the atherosclerotic plaques.

  9. Macrosialin does not function as an oxLDL receptor on the cell surface.

  10. Data show that macrosialin (CD68), a macrophage-specific protein, is increased by aging in selected brain regions of male C57BL/6NNia mice.

Human CD68 Molecule (CD68) interaction partners

  1. Most cases of histiocytic sarcoma expressed histiocytic markers CD68 (6 of 7 cases), CD163 (show CD163 Proteins) (5 of 5 cases), and PU.1 (3 of 4 cases).

  2. Renal expression of CD68 and the chronicity index are associated with progression to chronic kidney disease in patients with proliferative lupus nephritis.

  3. Results indicate that the expression of FoxP3 (show FOXP3 Proteins) was not significantly associated with survival, and suggest prognostic significance of high CD68 expression in primary central nervous system lymphoma (PCNSL).

  4. Her-2 (show ERBB2 Proteins) overexpression results in ICA were similar to previous reports, the finding of 28% in HGD (show HGD Proteins) was unexpected and may have clinical implications. Positive Her-2 (show ERBB2 Proteins) DISH in 6% of LGD is novel, suggesting a role of Her-2 (show ERBB2 Proteins) during BE progression

  5. CD68 may play key roles in the pathogenesis of Alzheimer's disease (AD) and its complications may be via induction of inflammation; CD68 may be considered as a risk factor for development of AD and also psychotic symptoms in the patients

  6. hCD68GFP/ApoE (show APOE Proteins)(-/-) mice provide a new approach to study macrophage accumulation in atherosclerotic plaque progression and to identify cells recruited from adoptively transferred monocytes.

  7. Findings indicate that human CD68 and its mouse ortholog macrosialin located in the lysosomal membrane and share many structural similarities.

  8. The strong CD68 and S100 co-expression in our case did not allow a clear-cut discrimination between the immunophenotype of histiocytic neoplasms and amelanotic melanoma, because of CD68 immunoreactivity occurring in 75% of metastatic malignant melanomas

  9. Using double labeling with Iba-1 (show AIF1 Proteins) and cd68 could determine the physiological state of microglia in brain contusion based on their morphology and immunoreactivity.

  10. we confirmed the similarities between epithelial ovarian cancer and fallopian tube, normal and adenocarcinoma using FOLR1 (show FOLR1 Proteins), FOLR2 (show FOLR2 Proteins), CD68 and CD11b (show ITGAM Proteins) markers

CD68 Protein Profile

Protein Summary

This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.

Gene names and symbols associated with CD68 Molecule Proteins (CD68)

  • CD68-like (LOC100344094)
  • CD68 antigen (Cd68)
  • Cd68 molecule (Cd68)
  • CD68 molecule (CD68)
  • GP110 protein
  • LAMP4 protein
  • SCARD1 protein

Protein level used designations for CD68 Molecule Proteins (CD68)

macrosialin , CD68 antigen , macrophage antigen CD68 , scavenger receptor class D, member 1

GENE ID SPECIES
100344094 Oryctolagus cuniculus
12514 Mus musculus
287435 Rattus norvegicus
968 Homo sapiens
504960 Bos taurus
101099002 Felis catus
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