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CD68 encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. Additionally we are shipping CD68 Antibodies (631) and CD68 Kits (33) and many more products for this protein.
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Findings indicate that human CD68 and its mouse ortholog macrosialin located in the lysosomal membrane and share many structural similarities.
Myeloid osteoclast precursors do not express CD68.
CD68, a putative receptor for sporozoite invasion of Kupffer cells that acts as a gateway for malaria infection of the liver.
Results showed that activated microglia in Alzheimer's disease-like mice showed two-step transition: a CD68-negative activated form at 6-9 months and a CD68-positive form from 12 months of age
Statins promote the beneficial remodeling of plaques in diseased mouse arteries through the stimulation of the CCR7 (show CCR7 Proteins) / CD68 emigration pathway in macrophages
These findings demonstrate a role for CD68 in the function of osteoclasts.
CD68-null mononuclear phagocytes exhibited a trend toward enhanced antigen presentation to CD4+ T cells, indicating that CD68 may function to negatively regulate antigen uptake, loading, or major histocompatibility complex class II trafficking.
Atherogenic diet-induced reduction in lipid levels of Reversa model mouse leads to decreased monocyte-derived CD68-positive cells in advanced atherosclerotic plaques and is associated with emigration of these cells from the atherosclerotic plaques.
Macrosialin does not function as an oxLDL receptor on the cell surface.
Data show that macrosialin (CD68), a macrophage-specific protein, is increased by aging in selected brain regions of male C57BL/6NNia mice.
High expression of CD68 is associated with nonalcoholic steatohepatitis.
increased amount of CD68+TAM (show CCNA1 Proteins) in gaps of ductal tumor structures is protective against metastatic spread in regional lymph nodes.
Most cases of histiocytic sarcoma expressed histiocytic markers CD68 (6 of 7 cases), CD163 (show CD163 Proteins) (5 of 5 cases), and PU.1 (3 of 4 cases).
Renal expression of CD68 and the chronicity index are associated with progression to chronic kidney disease in patients with proliferative lupus nephritis.
Results indicate that the expression of FoxP3 (show FOXP3 Proteins) was not significantly associated with survival, and suggest prognostic significance of high CD68 expression in primary central nervous system lymphoma (PCNSL).
Her-2 (show ERBB2 Proteins) overexpression results in ICA were similar to previous reports, the finding of 28% in HGD (show HGD Proteins) was unexpected and may have clinical implications. Positive Her-2 (show ERBB2 Proteins) DISH in 6% of LGD is novel, suggesting a role of Her-2 (show ERBB2 Proteins) during BE progression
CD68 may play key roles in the pathogenesis of Alzheimer's disease (AD) and its complications may be via induction of inflammation; CD68 may be considered as a risk factor for development of AD and also psychotic symptoms in the patients
hCD68GFP/ApoE (show APOE Proteins)(-/-) mice provide a new approach to study macrophage accumulation in atherosclerotic plaque progression and to identify cells recruited from adoptively transferred monocytes.
The strong CD68 and S100 co-expression in our case did not allow a clear-cut discrimination between the immunophenotype of histiocytic neoplasms and amelanotic melanoma, because of CD68 immunoreactivity occurring in 75% of metastatic malignant melanomas
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.
, CD68 antigen
, macrophage antigen CD68
, scavenger receptor class D, member 1