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The catalytic conversion of UTP to CTP is accomplished by the enzyme cytidine-5-prime-triphosphate synthetase. Additionally we are shipping CTP Synthase, CTPS Antibodies (23) and and many more products for this protein.
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Rods and rings (RR) are protein assemblies composed of CTPS1 and IMPDH2. Glutamine deprivation initiates reversible assembly of mammalian rods and rings.
results highlight a key and specific role of CTPS1 in the immune system by its capacity to sustain the proliferation of activated lymphocytes during the immune response
analysis of the kinetic properties of hCTPS1 and hCTPS2, and determination that Ser (show SIGLEC1 Proteins)(68) is a major site of CTPS2 (show CTPS2 Proteins) regulation by phosphorylation
CTP synthetase is phosphorylated by protein kinase A
Data indicate that protein kinase C phosphorylation at Ser (show SIGLEC1 Proteins)(462) stimulates human CTP synthetase 1 activity, whereas phosphorylation at Thr (show TRH Proteins)(455) inhibits activity.
analysis of phosphorylation and regulation of human CTPS1 in human cells shows that GSK3 is a novel regulator of CTPS activity
studies provide novel information on the potential interacting proteins that may regulate CTPS1 function or intracellular localization
CTPS1 inhibition selectively blocks smooth muscle cell proliferation without disturbing or even promoting re-endothelialization for effective vascular repair after injury.
Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway.
The catalytic conversion of UTP to CTP is accomplished by the enzyme cytidine-5-prime-triphosphate synthetase. The enzyme is important in the biosynthesis of phospholipids and nucleic acids, and plays a key role in cell growth, development, and tumorigenesis. The region to which the CTPS gene has been mapped is the location of breakpoints involved in several tumor types
CTP synthase 1
, CTP synthase 1-B
, CTP synthetase 1-B
, UTP--ammonia ligase 1-B
, cytidine 5'-triphosphate synthase
, CTP synthetase 1
, UTP--ammonia ligase 1
, cytidine 5'-triphosphate synthetase
, cytidine 5-prime triphosphate synthetase
, CTP synthase a