anti-C-Type Lectin Domain Family 4, Member E (CLEC4E) Antibodies

CLEC4E encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Additionally we are shipping CLEC4E Kits (16) and CLEC4E Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CLEC4E 26253 Q9ULY5
CLEC4E 56619 Q9R0Q8
CLEC4E 450223 Q67EQ1
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Top anti-CLEC4E Antibodies at antibodies-online.com

Showing 10 out of 63 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated EIA, IF, IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Human Mouse Un-conjugated ELISA, ICC, IF, IHC, IHC (p), WB Western Blot: CLEC4E Antibody (16E3) [NBP1-49311] - Cell lysates of HeLa (35ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human CLEC4E (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Immunohistochemistry-Paraffin: CLEC4E Antibody (16E3) [NBP1-49311] - Paraffin embedded sections of colorectal cancer tissue were incubated with anti-human MINCLE antibody (1:50) for 2 hours at room temperature. Antigen retrieval was performed in 0.1M sodium citrate buffer and detected using Diaminobenzidine (DAB). 0.1 mL Log in to see 10 to 13 Days
$381.94
Details
Human Mouse Un-conjugated ELISA, WB CLEC4E monoclonal antibody (M08), clone 2D12. Western Blot analysis of CLEC4E expression in K-562. Western Blot detection against Immunogen (49.83 KDa) . 100 μg Log in to see 11 to 12 Days
$430.00
Details
Human Mouse Un-conjugated WB 100 μg Log in to see 2 to 3 Days
$260.00
Details
Human Mouse Un-conjugated FACS, IHC, WB Immunohistochemistry: CLEC4E Antibody (2A8) [NBP2-45629] - Analysis of Human Ovary tissue. Immunohistochemistry: CLEC4E Antibody (2A8) [NBP2-45629] - Analysis of Adenocarcinoma of Human ovary tissue. 0.1 mL Log in to see 8 to 11 Days
$513.19
Details
Human Mouse Un-conjugated FACS, IHC (p), WB 100 μL Log in to see 7 to 9 Days
$529.83
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 2 to 3 Days
$240.00
Details
Human Rabbit Un-conjugated WB Western blot testing of human samples with CLEC4E antibody at 2ug/ml. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB Western Blot: CLEC4E Antibody [NBP2-27093] - analysis of CLEC4E using CLEC4E antibody. Human spleen cell lysate in the 1) absence and 2) presence of immunizing peptide, 3) mouse spleen, 4) rat spleen, 5) Ramos and 6) THP1 cell lysate probed with 2 ug/ml of CLEC4E antibody. ¡¦s goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test. 0.1 mg Log in to see 7 to 9 Days
$317.63
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: CLEC4E Antibody [NBP2-13844] - Staining of human cell line U-251MG shows positivity in cytoplasm. Dilution: 1 - 4 ug/ml Western Blot: CLEC4E Antibody [NBP2-13844] - Lane 1: Marker [kDa] 229, 112, 84, 48, 32, 27, 17.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp.Lane 4: Human plasma (IgG/HSA depleted).Lane 5: Human liver tissue.Lane 6: Human tonsil tissue 0.1 mL Log in to see 10 to 13 Days
$439.69
Details

CLEC4E Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-CLEC4E Antibodies

  1. Human Monoclonal CLEC4E Primary Antibody for EIA, IF - ABIN487350 : Ishikawa, Ishikawa, Morita, Toyonaga, Yamada, Takeuchi, Kinoshita, Akira, Yoshikai, Yamasaki: Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle. in The Journal of experimental medicine 2009 (PubMed)
    Show all 3 references for 487350

  2. Human Monoclonal CLEC4E Primary Antibody for ELISA, WB - ABIN565251 : Bugarcic, Hitchens, Beckhouse, Wells, Ashman, Blanchard: Human and mouse macrophage-inducible C-type lectin (Mincle) bind Candida albicans. in Glycobiology 2008 (PubMed)
    Show all 2 references for 565251

  3. Human Monoclonal CLEC4E Primary Antibody for ELISA, ICC - ABIN4299166 : de Rivero Vaccari, Brand, Berti, Alonso, Bullock, de Rivero Vaccari: Mincle signaling in the innate immune response after traumatic brain injury. in Journal of neurotrauma 2015 (PubMed)

More Antibodies against CLEC4E Interaction Partners

Human C-Type Lectin Domain Family 4, Member E (CLEC4E) interaction partners

  1. combination adjuvant systems demonstrate markedly different immune activation with age, with combined DC activation via Macrophage-inducible C-type lectin and TLR7 (show TLR7 Antibodies)/8 representing a novel approach to enhance the efficacy of early-life vaccines.

  2. We here show that Mincle gene expression was induced in alveolar macrophages and neutrophils in bronchoalveolar lavage fluids of mice and patients with pneumococcal pneumonia

  3. a nonredundant role for Clec4e in coordinating major biological pathways involved in atherosclerosis

  4. CLEC4E expression is significantly upregulated in human masticatory mucosa during wound healing

  5. The expression of Mincle increases significantly during the early period of Aspergillus fumigatus infection, while expression of eight corresponding cytokines changes. Mincle, as a pattern recognition receptor, may play a role in the early innate immune response of the corneal resistance against fungus.

  6. Induction of Mincle by Helicobacter pylori and consequent anti-inflammatory signaling denote a bacterial survival strategy.

  7. our findings identify mincle as a contributor to the inflammatory response after traumatic brain injury

  8. Data indicate that MINCLE receptor is able to mediate the response to trehalose-6,6-dimycolate (TDM) dependent on SYK (show SYK Antibodies) kinase and CARD9 (show CARD9 Antibodies) protein.

  9. mincle is a fungal receptor that can suppress antifungal immunity and, as such, is a potential therapeutic target.

  10. These results demonstrated that GroMM is a unique ligand for human Mincle that is not recognized by mouse Mincle.

Mouse (Murine) C-Type Lectin Domain Family 4, Member E (CLEC4E) interaction partners

  1. Mincle deletion results in TLR4 (show TLR4 Antibodies)-mediated inflammation.

  2. Priming by Mincle-deficient dendritic cells (DCs).

  3. Thus, macrophage activation by the corynebacterial cell wall relies on TLR2 (show TLR2 Antibodies)-driven robust Mincle expression and the cooperative action of both receptors.

  4. this study shows that immune activation in vitro and in vivo by trehalose esters of simple fatty acids requires two acyl chains of length and involves Mincle

  5. Attenuated neutrophil extracellular trap formation in Mincle-/- neutrophils correlates with impaired autophagy activation in vitro and in vivo, whereas reactive oxygen species formation in these neutrophils remained intact.

  6. We here show that Mincle gene expression was induced in alveolar macrophages and neutrophils in bronchoalveolar lavage fluids of mice and patients with pneumococcal pneumonia

  7. this study shows a significant role for Mincle in Pneumocystis modulating host defense during infection

  8. The authors report that microbial stimulation triggers Mincle (Clec4e) expression through the myeloid differentiation primary response gene 88 (MyD88 (show MYD88 Antibodies)) pathway; a process that does not require MCL (Clecsf8 (show CLEC4D Antibodies), Clec4d (show CLEC4D Antibodies)). Conversely, they show that MCL (show CLEC4D Antibodies) is constitutively expressed but retained intracellularly until Mincle is induced, whereupon the receptors form heterodimers which are translocated to the cell surface.

  9. a nonredundant role for Clec4e in coordinating major biological pathways involved in atherosclerosis

  10. this paper shows that mycobacterial cell envelope glycolipid TDM modulates TLR2 (show TLR2 Antibodies)-mediated IL-10 (show IL10 Antibodies) and IL-12p40 responses in macrophages through Mincle, which is, in turn, up-regulated by Mycobacterium bovis BCG (show SLC11A1 Antibodies)

Cow (Bovine) C-Type Lectin Domain Family 4, Member E (CLEC4E) interaction partners

  1. The structure of an extended portion of the extracellular domain of mincle, beyond the minimal C-type carbohydrate recognition domain, also constrains the way the binding domains may interact on the surface of macrophages.

  2. The data demonstrate how mincle bridges between the surfaces of the macrophage and the mycobacterium.

Guinea Pig C-Type Lectin Domain Family 4, Member E (CLEC4E) interaction partners

  1. the function of the guinea pig homologue of Mincle (gpMincle) and MCL (show CLEC4D Antibodies) (gpMCL). gpMincle directly bound to trehalose-6,6'-dimycolate

CLEC4E Antigen Profile

Protein Summary

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

Gene names and symbols associated with CLEC4E

  • C-type lectin domain family 4, member E (CLEC4E) antibody
  • C-type lectin domain family 4, member e (Clec4e) antibody
  • C-type lectin domain family 4, member E (Clec4e) antibody
  • C-type lectin domain family 4, member E (LOC100350649) antibody
  • C86253 antibody
  • CLEC4E antibody
  • Clecsf9 antibody
  • Mincle antibody

Protein level used designations for CLEC4E

C-type lectin domain family 4, member E , C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9 , C-type lectin domain family 4 member E , C-type lectin superfamily member 9 , macrophage-inducible C-type lectin , C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 9 , C-type lectin, superfamily member 9 , immunoreceptor

GENE ID SPECIES
611538 Canis lupus familiaris
722250 Macaca mulatta
735637 Pan troglodytes
100135686 Ovis aries
26253 Homo sapiens
56619 Mus musculus
450223 Rattus norvegicus
514797 Bos taurus
100350649 Oryctolagus cuniculus
100726838 Cavia porcellus
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