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The protein encoded by CAST is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. Additionally we are shipping Calpastatin Kits (14) and Calpastatin Proteins (12) and many more products for this protein.
Showing 10 out of 77 products:
Human Polyclonal Calpastatin Primary Antibody for - ABIN2172219
Huang, Rose, Hoffmann, Hashimoto, Bertino, Denk, Takano, Iwata, Saido, Hoffmann: Calpastatin prevents NF-?B-mediated hyperactivation of macrophages and attenuates colitis. in Journal of immunology (Baltimore, Md. : 1950) 2013
Loss of CAST in angiogenic ECs facilitates mu (show JAK3 Antibodies)-calp (show STAT1 Antibodies)ain-induced SOCS3 degradati (show SOCS3 Antibodies)on, which amplifies p (show VEGFC Antibodies)athological angiogenesis through interleukin-6/STAT3/VEGF-C axis.
We describe PLACK syndrome, as a clinical entity of defective epidermal adhesion, caused by loss-of-function mutations in calpastatin.
Calpastatin binds with Cav1.2 (show CACNA1C Antibodies) amino acid motifs in a calcium dependent manner.
Calpastatin gene (CAST) is not associated with late onset sporadic Parkinson's disease in the Han Chinese population.
HER2 (show ERBB2 Antibodies) inhibited calpain-1 (show CAPN1 Antibodies) activity through upregulating calpastatin, an endogenous calpain inhibitor.
The results suggest that calpain-2 (show CAPN2 Antibodies) and calpastatin expression is important in pancreatic cancers, influencing disease progression
Neuronal overexpression of calpastatin modulates amyloid precursor protein (show APP Antibodies) processing in brains of transgenic beta-amyloid depositing mice.
Calpastatin overexpression reduces calpain-mediated proteolysis and behavioral impairment after traumatic brain injury.
Mycoplasma hyorhinis membrane lipoproteins induce calpastatin upregulation in human cells
calpastatin-calpain balance varied during Th-1,2, and -17 development; overexpression of a domain of calpastatin suppressed production of IL-6 (show IL6 Antibodies) and IL-17 (show IL17A Antibodies) by Th cells and of IL-6 (show IL6 Antibodies) by fibroblasts; suppression of IL-6 (show IL6 Antibodies) occurred by reducing NF-kappaB (show NFKB1 Antibodies) signaling
CT1 (show SLC6A8 Antibodies) decreases cell death through a mechanism related to Stat3 (show STAT3 Antibodies) and Akt (show AKT1 Antibodies) phosphorylation and activation of calpastatin in D-galactosamine-treated hepatocytes.
CAST gene affected post-mortem activation time of calpain and drip loss.
The quality of meat influenced by RYR1 (show RYR1 Antibodies) genotype may be modified by the simultaneous influence of genotype as regards the CAST locus
The effect of the beta-adrenergic agonist clenbuterol and porcine ST (pST (show SULT1A1 Antibodies)) treatment on calpastatin promoter usage in vivo and in vitro are reported.
The Decreased expression of calpastatin mRNA during development is highly correlated with muscle protein accumulation in neonatal Sus scrofa.
The suppression of calpastatin resulted in the increased expression of mu-calpain (show CAPNL1 Antibodies), caspases, and HSPs which in turn regulate apoptotic cell death.
This work is supportive of the importance of CAPN1 (show CAPNL1 Antibodies) and CAST for mean tenderness in beef.
bovine CAPN-CAST interaction were well reflected in the geometry between the pharmacophore features and its shape constraints identified using our modeled bovine CAPN1 (show CAPNL1 Antibodies)/CAST4 complex structures
CAST binds and inhibits CAPN via its CAPN-inhibitor domains(CAST1 (show ERC2 Antibodies)-4) .CAST4 docks near the flexible active site of CAPN1 (show CAPNL1 Antibodies), conformational changes at the interaction site after binding could be directly related to CAST4 inhibitory activity.
This work confirms the importance of CAPN1 (show CAPNL1 Antibodies) and CAST for tenderness in beef, provides a new effect of CAST on beef tenderness, and questions the utility of GHR (show GHR Antibodies) as a selection marker for beef quality.
The association of single nucleotide polymorphisms in calpastatin with muscle tenderness was studied.
Association of polymorphisms in calpain 1 (show CAPN1 Antibodies), (mu/I) large subunit, calpastatin, and cathepsin D (show CTSD Antibodies) genes with meat quality traits in double-muscled Piemontese cattle.
The CAST28 genotypes showing allele frequencies of C (0.429) and T (0.571) were significantly associated with calpastatin activity and Warner-Bratzler Shear Force in beef.
The association of polymorphisms in calpastatin and mu-calpain (show CAPNL1 Antibodies) genes with meat tenderness in 3 French beef breeds is reported.
characteristic properties of ER membrane m-calpain (show CAPN2 Antibodies) (MCp (show CD46 Antibodies)), calpastatins and lumen m-calpain (show CAPN2 Antibodies) (LCp (show KLHDC2 Antibodies)) and a brief comparative study between MCp (show CD46 Antibodies) and LCp (show KLHDC2 Antibodies)
Defective scar formation after myocardial infarction in calpastatin transgenic mice was associated with blunted CD4 (show CD4 Antibodies)(+) T-cell and M2-macrophage recruitment.
Over-expression of Cast inhibits calpain activation and attenuates post-infarction myocardial remodeling.
EC-specific transgenic CAST downregulated JAK (show JAK3 Antibodies)/STAT (show STAT1 Antibodies) signals, upregulated SOCS3 (show SOCS3 Antibodies), and depleted VEGF-C (show VEGFC Antibodies), counteracting unstable pathological neovessels and disease progression in tumors and oxygen-induced retinopathy lesions in mice.
Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-synuclein (show SNCA Antibodies) processing, aggregation and synaptic impairment in transgenic mice.
We observed that ischemia induction results in increased expression of CaN, Calp (show KCNIP4 Antibodies) and Calpn.
Over-expression of calpastatin enhances doxorubicin-induced cardiac injuries through calpain inhibition.
The calpain/calpastatin system has opposing roles in growth and metastatic dissemination of melanoma.
yeast A34.5 (show CD3EAP Antibodies)/A49 and mammalian PAF49 (show CD3EAP Antibodies)/PAF53 (show POLR1E Antibodies) heterodimeric complexes interact through species-specific sequence elements that appear to assume similar structural motifs.
Data show that genetic deficiency of calpastatin (CS) augmented Abeta (show APP Antibodies) amyloidosis, tau phosphorylation, microgliosis, and somatodendritic dystrophy, and increased mortality in amyloid precursor protein (APP (show APP Antibodies)) transgenic mice.
PIN1 apparently restrains the ability of calpastatin to inhibit calpain, maintaining calpain activity in endothelial cells.
The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described.
, calpain inhibitor
, sperm BS-17 component
, calpastatin isoform III
, calpastatin type I
, calpastatin type II
, calpastatin type III
, CD3 epsilon associated protein; antisense to Ercc1
, CD3-epsilon-associated protein
, CD3E-associated protein
, DNA-directed RNA polymerase I subunit RPA34
, RNA polymerase I-associated factor PAF49
, anti-sense to ERCC-1 protein