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The protein encoded by CASQ1 is a mitochondrial calcium-binding protein located in the luminal space of the terminal cisternae of the sarcoplasmic reticulum. Additionally we are shipping Calsequestrin Antibodies (27) and Calsequestrin Proteins (11) and many more products for this protein.
Showing 5 out of 11 products:
Calcium entry activated by ablation of both JP45 (show JSRP1 ELISA Kits)-CASQ1 and JP45 (show JSRP1 ELISA Kits)-CASQ2 (show CASQ2 ELISA Kits) complexes supports tetanic force development in slow twitch soleus muscles.
Transient knockdown of annexin A6 (show ANXA6 ELISA Kits) and calsequestrin 1 protein of high-active mice with vivo-morpholinos resulted in decreased physical activity levels (P = 0.001).
Ca(2 (show CA2 ELISA Kits)+) transients evoked by tetanic stimulation are the result of massive Ca(2 (show CA2 ELISA Kits)+) influx due to enhanced Ca(v)1.1 (show CACNA1S ELISA Kits) channel activity, which restores muscle strength in JP45 (show JSRP1 ELISA Kits)/CASQ1 double knockout mice.
Protein levels of CSQ1, SERCA1 (show ATP2A1 ELISA Kits), and SERCA2 (show ATP2A2 ELISA Kits) are re-adjusted in skeletal muscles depending on the demands of diverse exercise training programs.
results support the view that in skeletal muscles, CASQ1 plays a key role in both Ca(2 (show CA2 ELISA Kits)+) homeostasis and terminal cisternae structure
The results presented in this paper unmask a differential effect of CASQ1&2 ablation in fast versus slow fibers
Calsequestrin not only stores Ca(2 (show CA2 ELISA Kits)+), but also varies its affinity in ways that progressively increase the ability of the store to deliver Ca(2 (show CA2 ELISA Kits)+) as it becomes depleted, a novel feedback mechanism of potentially valuable functional implications.
effect of nockdown of CSQ1 in adult mouse skeletal muscle on Store-operated Ca(2 (show CA2 ELISA Kits)+) entry
knocking down CSQ2, but not CSQ1, leads to reduced Ca2 (show CA2 ELISA Kits)+ storage and release in C2C12 myotubes
CSQ1 is essential for the normal development of the sarcoplasmic reticulum (SR) and its calcium release units and for the storage and release of appropriate amounts of SR Ca(2 (show CA2 ELISA Kits)+).
a mechanism for the observed in vitro and in vivo dynamic high-capacity and low-affinity Ca(2 (show CA2 ELISA Kits)+)-binding activity of calsequestrin
Purified skeletal ryanodine receptors are similarly activated by purified triadin (show TRDN ELISA Kits) or purified junctin (show ASPH ELISA Kits) added to their luminal side, although a lack of competition indicated that the proteins act at independent sites.
the p.D244G variant in CASQ1 is associated with a skeletal muscle disease and alters sarcoplasmic calcium release
Calsequestrin-1 monomers suppress Store-Operated Ca2 (show CA2 ELISA Kits)+ Entry by interacting with STIM1 (show STIM1 ELISA Kits) and attenuating STIM1 (show STIM1 ELISA Kits) aggregation via its C-terminal amino acid 362-396.
the protein aggregate myopathy with benign evolution and muscle inclusions composed of excess CASQ1 due to the D244G heterozygous missense mutation in the CASQ1 gene
Equilibrium dialysis and turbidity measurements showed that D244G and, to a lesser extent, M87T partially lose Ca(2 (show CA2 ELISA Kits)+) binding exhibited by wild type calsequestrin 1 at high Ca(2 (show CA2 ELISA Kits)+) concentrations.
Missense mutation in CASQ1 gene causes the formation of abnormal sarcoplasmic reticulum (SR) vacuoles containing aggregates of CASQ1 results in altered Ca2 (show CA2 ELISA Kits)+ release, and vacuolar myopathy patients phenotype.
The sarcoplasmic reticulum calcium content in human type II fibres is primarily determined by the CSQ1 abundance, and in type I fibres, by the combined amounts of both CSQ1 and CSQ2.
a direct interaction of dysferlin (show DYSF ELISA Kits) with Trim72/MG53 (show TRIM72 ELISA Kits), AHNAK (show AHNAK ELISA Kits), cytoplasmic dynein (show DYNC1H1 ELISA Kits), myomesin-2 (show MYOM2 ELISA Kits) and calsequestrin-1, but not with caveolin-3 (show CAV3 ELISA Kits) or dystrophin (show DMD ELISA Kits), is reported.
CASQ1 is not a major malignant hyperthermia susceptibility locus in the North American population
Downregulation of CSQ-1 in diabetic platelets and impairment of CSQ-1 in normal cells leads to disturbed Ca(2 (show CA2 ELISA Kits)+) release, demonstrating a potential role for CSQ-1 in the regulation of the platelet Ca(2 (show CA2 ELISA Kits)+) release process
The protein encoded by this gene is a mitochondrial calcium-binding protein located in the luminal space of the terminal cisternae of the sarcoplasmic reticulum. The protein binds and putatively stores calcium ions. The protein is absent in patients with Duchenne and Becker types of muscular dystrophy.
, calsequestrin, skeletal muscle isoform
, laminin-binding protein
, skeletal muscle calsequestrin 1
, Laminin-binding protein
, calsquestrin 1
, calsequestrin homologue