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Transcriptional repressor which may play a role in development of the central nervous system (CNS).. Additionally we are shipping CIC Kits (4) and and many more products for this protein.
Showing 10 out of 46 products:
Cow (Bovine) Polyclonal CIC Primary Antibody for IHC, WB - ABIN2779683
Lee, Chan, Cheung, Cheng, Appleby, Orme, Scotting: CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons. in Brain research. Molecular brain research 2002
Show all 2 Pubmed References
Results indicate an important role for transcriptional repression factor Capicua (CIC) in regulating neural cell proliferation and lineage specification, and suggest that CIC mutations may impact the pathogenesis and therapeutic targeting of oligodendroglioma.
The data shows that Cic is an essential gene in mouse development and that systemic disruption of Cic DNA binding in adult mice causes T-cell acute lymphoblastic lymphoma
Our findings indicate that CIC is a critical regulator of BA homeostasis, and that its dysfunction might be associated with chronic liver disease and metabolic disorders.
mechanism by which constitutive reduction of Cic rescues Spinocerebellar ataxia type 1
Severe developmental bone phenotype in Cic deficient mice is reported.
Results describe the identification and characterization of a new gene, Cic, in both human and mouse genomes, that is implicated in granule cell development.
The ATXN1L (show ATXN1L Antibodies)-CIC-ETS transcription factor (show FEV Antibodies) axis as a mediator of resistance to MAPKi.
CIC deficiency was associated with disruptions in the expression of genes involved in cell-cell adhesion, and in the development of several cell and tissue types. We also showed that loss of CIC leads to overexpression of downstream members of the mitogen-activated protein kinase (show MAPK1 Antibodies) (MAPK (show MAPK1 Antibodies)) signalling cascade, indicating that CIC deficiency may present a novel mechanism for activation of this oncogenic pathway.
Case Report: genetically distinct variant of CIC-rearranged sarcomas with a novel NUTM2A-CIC fusion.
Findings show CIC-DUX4 sarcomas occur mostly in young adults within the somatic soft tissues, having a wide spectrum of morphology including round, epithelioid and spindle cells, and associated with an aggressive clinical course, with an inferior survival compared with Ewing sarcoma. Results support classification of CIC-rearranged tumors as an independent molecular and clinical subset of small blue round cell tumors.
Targeted next-generation sequencing of CIC-DUX4 soft tissue sarcomas demonstrates low mutational burden and recurrent chromosome 1p loss.
Data indicate that the HMG (show SSRP1 Antibodies)-box of Capicua (CIC) does not bind DNA alone but instead requires a distant motif (referred to as C1) present at the C-terminus of all CIC proteins.
The aim of this study was to describe seven cases of CIC-DUX4 fusion-positive sarcomas, including the first reported example arising primarily in bone. Our series confirms that CIC-DUX4 fusion-positive sarcomas are aggressive tumours with an adverse prognosis
analysis of homozygous deletions of 19q13.2 and CIC in neuroblastoma (show ARHGEF16 Antibodies)
Report CIC genetic alterations in angiosarcomas.
Transcriptional repressor which may play a role in development of the central nervous system (CNS).
capicua homolog (Drosophila)
, capicua homolog
, protein capicua homolog