anti-Capicua Homolog (Drosophila) (CIC) Antibodies

Transcriptional repressor which may play a role in development of the central nervous system (CNS).. Additionally we are shipping CIC Kits (4) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CIC 71722 Q924A2
CIC 23152 Q96RK0
CIC 308435  
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Top anti-CIC Antibodies at antibodies-online.com

Showing 10 out of 46 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB <b>WB Suggested Anti-CIC Antibody Titration: </b>1.25ug/ml<br><b>Positive Control: </b>Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IHC (p), WB CIC Antibody (N-term)  western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the CIC antibody detected the CIC protein (arrow). CIC antibody (N-term)  immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.  This data demonstrates the use of the CIC antibody (N-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB <span>CIC antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CIC antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.</span> <span>CIC Antibody (N-term) western blot analysis in mouse testis tissue lysates (35µg/lane).This demonstrates the CIC antibody detected the CIC protein (arrow).</span> 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Dog Rabbit Un-conjugated ICC, IF, IP Immunocytochemistry/Immunofluorescence: Capicua Antibody [ABIN2586285] - Capicua antibody was tested in Neuro 2A cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). 0.1 mg Log in to see 7 to 9 Days
$415.44
Details
Dog Rabbit Un-conjugated ICC, IF, IP, WB Western Blot: Capicua Antibody [ABIN2586306] - WB detection of Human Capicua /CIC in whole cell lysates of HeLa (5, 15 and 50 ug ) and 293T (T, 50 ug) cells using affinity purified rabbit Capicua antibody ABIN2586306 used at 1 ug/ml concentration. 0.1 mg Log in to see 7 to 9 Days
$556.31
Details
Human Rabbit Un-conjugated IF (p), IHC (p) Formalin-fixed and paraffin embedded mouse embryonic brain labeled with Anti-Capicua/CIC Polyclonal Antibody, Unconjugated (ABIN1387648) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$306.90
Details
Human Rabbit Un-conjugated WB Western blot analysis of CIC expression in HEK293T (A), Raw264.7 (B), PC12 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Cy5 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Cy5.5 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details

CIC Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-CIC Antibodies

  1. Cow (Bovine) Polyclonal CIC Primary Antibody for IHC, WB - ABIN2779683 : Lee, Chan, Cheung, Cheng, Appleby, Orme, Scotting: CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons. in Brain research. Molecular brain research 2002 (PubMed)
    Show all 2 Pubmed References

More Antibodies against CIC Interaction Partners

Mouse (Murine) Capicua Homolog (Drosophila) (CIC) interaction partners

  1. Results indicate an important role for transcriptional repression factor Capicua (CIC) in regulating neural cell proliferation and lineage specification, and suggest that CIC mutations may impact the pathogenesis and therapeutic targeting of oligodendroglioma.

  2. The data shows that Cic is an essential gene in mouse development and that systemic disruption of Cic DNA binding in adult mice causes T-cell acute lymphoblastic lymphoma

  3. Our findings indicate that CIC is a critical regulator of BA homeostasis, and that its dysfunction might be associated with chronic liver disease and metabolic disorders.

  4. mechanism by which constitutive reduction of Cic rescues Spinocerebellar ataxia type 1

  5. Severe developmental bone phenotype in Cic deficient mice is reported.

  6. Results describe the identification and characterization of a new gene, Cic, in both human and mouse genomes, that is implicated in granule cell development.

Human Capicua Homolog (Drosophila) (CIC) interaction partners

  1. Results indicate an important role for transcriptional repression factor Capicua (CIC) in regulating neural cell proliferation and lineage specification, and suggest that CIC mutations may impact the pathogenesis and therapeutic targeting of oligodendroglioma.

  2. The ATXN1L (show ATXN1L Antibodies)-CIC-ETS transcription factor (show FEV Antibodies) axis as a mediator of resistance to MAPKi.

  3. CIC deficiency was associated with disruptions in the expression of genes involved in cell-cell adhesion, and in the development of several cell and tissue types. We also showed that loss of CIC leads to overexpression of downstream members of the mitogen-activated protein kinase (show MAPK1 Antibodies) (MAPK (show MAPK1 Antibodies)) signalling cascade, indicating that CIC deficiency may present a novel mechanism for activation of this oncogenic pathway.

  4. Case Report: genetically distinct variant of CIC-rearranged sarcomas with a novel NUTM2A-CIC fusion.

  5. Findings show CIC-DUX4 sarcomas occur mostly in young adults within the somatic soft tissues, having a wide spectrum of morphology including round, epithelioid and spindle cells, and associated with an aggressive clinical course, with an inferior survival compared with Ewing sarcoma. Results support classification of CIC-rearranged tumors as an independent molecular and clinical subset of small blue round cell tumors.

  6. Targeted next-generation sequencing of CIC-DUX4 soft tissue sarcomas demonstrates low mutational burden and recurrent chromosome 1p loss.

  7. Data indicate that the HMG (show SSRP1 Antibodies)-box of Capicua (CIC) does not bind DNA alone but instead requires a distant motif (referred to as C1) present at the C-terminus of all CIC proteins.

  8. The aim of this study was to describe seven cases of CIC-DUX4 fusion-positive sarcomas, including the first reported example arising primarily in bone. Our series confirms that CIC-DUX4 fusion-positive sarcomas are aggressive tumours with an adverse prognosis

  9. analysis of homozygous deletions of 19q13.2 and CIC in neuroblastoma (show ARHGEF16 Antibodies)

  10. Report CIC genetic alterations in angiosarcomas.

CIC Antigen Profile

Protein Summary

Transcriptional repressor which may play a role in development of the central nervous system (CNS).

Gene names and symbols associated with CIC

  • capicua transcriptional repressor b (cicb) antibody
  • capicua transcriptional repressor (CIC) antibody
  • capicua transcriptional repressor (Cic) antibody
  • 1200010B10Rik antibody
  • CIC antibody
  • mKIAA0306 antibody
  • wu:fb93c01 antibody

Protein level used designations for CIC

capicua homolog (Drosophila) , capicua homolog , protein capicua homolog

GENE ID SPECIES
323246 Danio rerio
456073 Pan troglodytes
484475 Canis lupus familiaris
71722 Mus musculus
23152 Homo sapiens
538483 Bos taurus
308435 Rattus norvegicus
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