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The protein encoded by CTNNBIP1 binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. Additionally we are shipping CTNNBIP1 Antibodies (40) and CTNNBIP1 Kits (4) and many more products for this protein.
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Human CTNNBIP1 Protein expressed in Escherichia coli (E. coli) - ABIN667025
Daniels, Weis: ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules. in Molecular cell 2002
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miR (show MLXIP Proteins)-29b plays a pivotal role in fetal mouse neurogenesis by regulating ICAT-mediated Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
Mechanistic studies revealed that CTNNBIP1 suppresses Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling and that miR (show MLXIP Proteins)-215 promotes beta-catenin (show CTNNB1 Proteins) activation and upregulates alpha-SMA (show SMN1 Proteins) and fibronectin (show FN1 Proteins) expression in TGF-beta1 (show TGFB1 Proteins)-treated MMCs by targeting CTNNBIP1
Overexpression of Icat induces G(2) arrest and cell death in tumor cell mutants for adenomatous polyposis coli (show APC Proteins), beta-catenin (show CTNNB1 Proteins), or Axin (show AXIN1 Proteins).
ICAT plays an important role in the anteriorization of neural cells by inhibiting the posteriorizing activity of Wnt (show WNT2 Proteins) signaling
These results suggest that the loss of ICAT gene function causes the arrest of UB branching and the apoptotic death of MM cells, resulting in renal agenesis.
Inhibition of beta-catenin (show CTNNB1 Proteins) signaling in articular chondrocytes causes increased cell apoptosis and articular cartilage destruction in Col2a1 (show COL2A1 Proteins)-ICAT- transgenic mice.
Data show that microRNA miR (show MLXIP Proteins)-215 activates beta-catenin (show CTNNB1 Proteins) pathways by decreasing catenin beta interacting protein 1 (CTNNBIP1)expression in gliomas.
Simultaneous silencing of beta-catenin (show CTNNB1 Proteins) and STAT3 (show STAT3 Proteins) synergistically induces apoptosis and inhibits cell proliferation in HepG2 liver cancer cells.
Finally, pro-incubation with idebenone inhibited mitochondrial dysfunction induced by oxLDL through the mitochondrial-dependent apoptotic pathway and GSK3beta/beta-catenin (show CTNNB1 Proteins) signalling pathways.
A potent beta-catenin (show CTNNB1 Proteins) inhibitor, ICAT/CTNNBIP1 was a direct target of miR (show MLXIP Proteins)-424-5p.
Particulate matter (PM10) downregulates E-Cadherin (show CDH1 Proteins)/beta-Catenin (show CTNNB1 Proteins) expression.
A statistically significant lapatinib- and gefitinib-induced repression of cyclin D1 (show CCND1 Proteins), MMP9 (show MMP9 Proteins) and beta-catenin (show CTNNB1 Proteins) in CERV196 cells.
Nuclear YAP (show YAP1 Proteins) and cytoplasmic beta-catenin (show CTNNB1 Proteins) play important roles in carcinogenesis.
miR (show MLXIP Proteins)-603 regulates glioma development via Wnt (show WNT2 Proteins)-beta-cateninn signaling pathway and its WIF1 (show WIF1 Proteins) and CTNNBIP1 targets.
These results indicate that beta-catenin translation is initiated via the IRES and this is regulated by PTX, suggesting that regulation of the IRES-dependent translation of beta-catenin may be involved in the cancer cell response to PTX treatment.
ICAT may serve as a tumor-suppressor in human glioma.
The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene.
, beta-catenin-interacting protein 1
, catenin, beta interacting protein 1 a
, catenin beta interacting protein 1 b
, catenin, beta interacting protein 1
, inhibitor of beta-catenin and Tcf-4
, beta-catenin-interacting protein ICAT