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May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1) (By similarity).. Additionally we are shipping CTNNAL1 Antibodies (25) and CTNNAL1 Kits (4) and many more products for this protein.
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Force-dependent conformational switch of alpha-catenin (show CTNNA1 Proteins) controls vinculin (show VCL Proteins) binding.
Alpha-catenin (show CTNNA1 Proteins) has a novel role in fine-tuning of tissues' viscosity and surface tension through contractility.
the interaction between alpha-catulin and alpha-dystrobrevin (show DTNA Proteins) is evolutionarily conserved in C. elegans and mouse muscles and strongly suggests that this interaction contributes to the integrity of the dystrophin (show DMD Proteins) complex
We observed the temporal and spatial distribution of CTNNAL1 expression in mouse lung tissue with the OVA-sensitized asthma model and found that the level of CTNNAL1 mRNA showed a prominent negative correlation with pulmonary resistance.
This study identifies the E-cadherin (show CDH1 Proteins)/catenin complex as a discriminative, partly polyamine-regulated feature of IL-4 (show IL4 Proteins)/IL-13 (show IL13 Proteins)-exposed alternatively activated macrophages
Alpha-catulin contributes to drug-resistance of melanoma by activating NF-kappaB (show NFKB1 Proteins) and AP-1 (show FOSB Proteins)
these results strongly indicate that alpha-catulin contributes to the invasive behavior of metastatic cells and may be used as a prognostic marker and future therapeutic target for patients with cancer.
our study shows that alpha-catulin plays a critical role in cancer metastasis
findings show that alpha-catulin is highly expressed in melanoma cells; expression of alpha-catulin promoted melanoma progression and occurred concomitantly with the downregulation of E-cadherin (show CDH1 Proteins) and the upregulation of expression of mesenchymal genes
a robust transcriptional CTNNAL1 up-regulation occurs during acute ozone-induced stress and is mediated at least in part by ozone-induced recruitments of LEF-1 (show LEF1 Proteins) and AP-2alpha (show TFAP2A Proteins) to the human CTNNAL1 promoter
Study provides evidence that alpha-catulin promotes tumor growth by preventing cellular senescence and suggests that downregulating alpha-catulin may be a promising therapeutic approach for cancer treatment.
Data show that alpha-dystrobrevin (show DTNA Proteins)-1 recruits alpha-catulin, which supersensitizes alpha(1D)-AR functional responses by recruiting effector molecules to the signalosome.
the Lbc/alpha-catulin axis participates in 5-HT (show DDC Proteins)-induced PASMC mitogenesis and RhoA (show RHOA Proteins)/ROCK signaling, and may be an interventional target in diseases involving vascular smooth muscle remodeling.
alpha-catulin maps precisely to the familial dysautonomia candidate region on 9q31.
Results show that alpha-catulin co-expression leads to increased Lbc-induced serum response factor activation and may modulate Rho pathway signaling in vivo by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor.
May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1) (By similarity).
, catenin alpha-like 1
, catenin (cadherin-associated protein), alpha-like 1
, alpha-catenin related protein
, alpha-catenin-related protein
, catenin alpha-like protein 1