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Cathepsin B Proteins (CTSB)

The protein encoded by CTSB is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally we are shipping Cathepsin B Antibodies (153) and Cathepsin B Kits (66) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CTSB 1508 P07858
CTSB 13030 P10605
CTSB 64529  
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Top Cathepsin B Proteins at antibodies-online.com

Showing 10 out of 47 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 50 μg Log in to see 16 to 41 Days
$346.50
Details
HOST_Escherichia coli (E. coli) Human GST tag Cathepsin B (CTSB) (AA 82-333), (partial) protein (GST tag) 50 μg Log in to see 9 to 11 Days
$242.00
Details
HOST_Human Cells Human His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Mouse His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_HEK-293 Human Un-conjugated   10 μg Log in to see 10 to 12 Days
$206.55
Details
HOST_HEK-293 Human His tag 10 μg Log in to see 2 to 3 Days
$252.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$563.20
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$739.20
Details

CTSB Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
,
Mouse (Murine) , ,

Rat (Rattus) , ,

Top referenced Cathepsin B Proteins

  1. Human Cathepsin B Protein expressed in HEK-293 - ABIN2666495 : Brix, Dunkhorst, Mayer, Jordans: Cysteine cathepsins: cellular roadmap to different functions. in Biochimie 2008 (PubMed)
    Show all 6 references for ABIN2666495

  2. Human Cathepsin B Protein expressed in Human Cells - ABIN2002943 : Chan, San Segundo, McCormick, Steiner: Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs. in Proceedings of the National Academy of Sciences of the United States of America 1986 (PubMed)
    Show all 4 references for ABIN2002943

  3. Human Cathepsin B Protein expressed in HEK-293 Cells - ABIN2180942 : Basrur, Yang, Kushimoto, Higashimoto, Yasumoto, Valencia, Muller, Vieira, Watabe, Shabanowitz, Hearing, Hunt, Appella: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. in Journal of proteome research 2003 (PubMed)
    Show all 3 references for ABIN2180942

  4. Mouse (Murine) Cathepsin B Protein expressed in Human Cells - ABIN2007292 : Roshy, Sloane, Moin: Pericellular cathepsin B and malignant progression. in Cancer metastasis reviews 2003 (PubMed)
    Show all 3 references for ABIN2007292

  5. Human Cathepsin B Protein expressed in Escherichia coli (E. coli) - ABIN1046772 : Cao, Taggart, Berquin, Moin, Fong, Sloane: Human gastric adenocarcinoma cathepsin B: isolation and sequencing of full-length cDNAs and polymorphisms of the gene. in Gene 1994 (PubMed)
    Show all 2 references for ABIN1046772

More Proteins for Cathepsin B (CTSB) Interaction Partners

Silk Worm Cathepsin B (CTSB) interaction partners

  1. Cathepsin B is involved in the programmed cell death of the fat body during B. mori metamorphosis, and that cathepsin B and cathepsin B contribute to B (show TDO2 Proteins). mori metamorphosis.

Human Cathepsin B (CTSB) interaction partners

  1. CTSB might be involved in the development and progression of hepatocellular carcinoma.

  2. Cathepsin B knockdown in oral cancer cells reduces cell migration.

  3. the authors applied the technique of nanoelectrode arrays to try to detect and compare cathepsin B activities in normal and breast cancer cells. It was found that protease activity correlated positively with the degree of malignancy cancer cells.

  4. shedding of surface proteins by extracellular cathepsins impacts intracellular signaling as demonstrated for regulation of Ras GTPase (show RACGAP1 Proteins) activity.

  5. High cathepsin is associated with drug resistance in neuroblastoma (show ARHGEF16 Proteins).

  6. The expressions of cathepsin B strongly correlated with the Mini-Mental State Examination scores of the Alzheimer disease. patients

  7. Integrin alphavbeta3 (show ITGAV Proteins) is required for cathepsin B-induced hepatocellular carcinoma progression

  8. The serum level of cathepsin L (show CTSL1 Proteins) decreased with age, while cathepsin B remained no significant difference between young and aged individuals

  9. enhanced activity and expression of cathepsin B contributes to an increased remodelling of extracellular matrix that favours leiomyoma growth

  10. SCD5 impairs SPARC (show SPARC Proteins) and cathepsin B secretion in human melanoma cells and intracellular pH acidification.

Mouse (Murine) Cathepsin B (CTSB) interaction partners

  1. IGF-1 (show IGF1 Proteins) promotes the growth and metastasis of hepatocellular carcinoma by inhibition of proteasome-mediated cathepsin B degradation.

  2. Aggregatibacter actinomycetemcomitans invasion of macrophages induces interleukin-1beta production through reactive oxygen species and cathepsin B.

  3. Findings indicate that Ctsb-/- BMDC display more pro-Th1 (show HAND1 Proteins) properties than their WT and Ctsl (show CTSL1 Proteins)-/- counterparts, and therefore suggest that Ctsb down-regulates the Th1 (show HAND1 Proteins) response to L. major.

  4. Cathepsin B showed the highest protein levels in the anterior segments of the gastrointestinal tract, whereas the highest activity was observed in the jejunum

  5. CtsB and CtsL (show CTSL1 Proteins) are essential in alpha-syn lysosomal degradation

  6. Reactive oxygen species and cathepsin B activities are necessary for maximal iNOS (show NOS2 Proteins) induction in C. muridarum-infected macrophages.

  7. CTSB protein functions as a necessary modulator of hypertrophic response by regulating TNF-alpha (show TNF Proteins)/ASK1 (show MAP3K5 Proteins)/JNK (show MAPK8 Proteins) signaling pathway involved in cardiac remodeling.

  8. Abeta (show APP Proteins) oligomers, but not fibrils, induce IL-1beta (show IL1B Proteins) production in primary microglia in a cathepsin B- and reactive oxygen species -dependent manner.

  9. Cathepsin B produces full-length amyloid-beta (Ab(1-40/42)) and pyroglutamate amyloid-beta (pyroGluAb(3-40/42) and is a key drug target for treating Alzheimer's disease by reducing these amyloid-beta species

  10. cysteine cathepsins B and S can directly cleave Rip1 (show RALBP1 Proteins)

Cow (Bovine) Cathepsin B (CTSB) interaction partners

  1. The cathepsin B deserves further evaluation as therapeutic targets to develop disease modifying drugs to treat Alzheimer's disease.

  2. evidence shows cathepsin B activity may not be redox regulated; however, the stability of the enzyme at neutral pH is dependent on redox potential, and on the presence of oxidising agents.

  3. Overexpressing cathepsin B reduced the Vascular Endothelial Growth Factor-dependent tube response

  4. The peptides, all of which contain a C-terminal free acid, were tested as inactivators of bovine cathepsin B, in an attempt at exploiting the known and, amongst the cysteine proteinases, unique carboxy dipeptidyl peptidase (show ACE Proteins) activity of the protease.

Pig (Porcine) Cathepsin B (CTSB) interaction partners

  1. Findings showed that CTSB facilitates adipogenesis, and its effect is associated with fibronectin degradation and Wnt/b-catenin signaling pathway.

  2. CTSB may be required to remodel endometrial and placental tissues for close apposition between maternal and fetal vasculatures and to facilitate transplacental transport of gases, micronutrients (amino acids, glucose), and macromolecules (proteins).

Cathepsin B (CTSB) Protein Profile

Protein Summary

The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with Cathepsin B Proteins (CTSB)

  • cathepsin B (ctsb)
  • cathepsin B (LOC692390)
  • cathepsin B (Catb-2744)
  • cathepsin B-1674 (Catb-1674)
  • cathepsin B-84 (Catb-84)
  • cathepsin B-3098 (Catb-3098)
  • cathepsin B-16D2 (Catb-16d2)
  • cathepsin B-1874 (Catb-1874)
  • cathepsin B-3483 (Catb-3483)
  • cathepsin B-10270 (Catb-10270)
  • cathepsin B (CTSB)
  • cathepsin B (Ctsb)
  • cathepsin B (LOC100101593)
  • ACYPI000009 protein
  • ACYPI000014 protein
  • ACYPI000017 protein
  • ACYPI000018 protein
  • ACYPI000019 protein
  • ACYPI000020 protein
  • ACYPI000021 protein
  • APPS protein
  • catb-16D protein
  • Catb-16d2 protein
  • Catb-84 protein
  • catb-1674a protein
  • Catb-1874 protein
  • Catb-2744 protein
  • Catb-3098 protein
  • Catb-3483 protein
  • Catb-10270 protein
  • CB protein
  • CPSB protein
  • CTSB protein
  • LOC692390 protein

Protein level used designations for Cathepsin B Proteins (CTSB)

cathepsin B , cathepsin B-2744 , cathepsin B-1674 , cathepsin B-84 , cathepsin B-3098 , cathepsin B-16D2 , cathepsin B-1874 , cathepsin B-3483 , cathepsin B-10270 , APP secretase , amyloid precursor protein secretase , cathepsin B1 , cysteine protease , RSG-2 , BCSB

GENE ID SPECIES
379257 Xenopus laevis
692390 Bombyx mori
100144781 Acyrthosiphon pisum
100144784 Acyrthosiphon pisum
100144787 Acyrthosiphon pisum
100144790 Acyrthosiphon pisum
100144791 Acyrthosiphon pisum
100144794 Acyrthosiphon pisum
100144795 Acyrthosiphon pisum
100144796 Acyrthosiphon pisum
100424758 Macaca mulatta
463993 Pan troglodytes
1508 Homo sapiens
13030 Mus musculus
64529 Rattus norvegicus
281105 Bos taurus
396329 Gallus gallus
100037961 Sus scrofa
780470 Ovis aries
100101593 Oryctolagus cuniculus
100173564 Pongo abelii
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