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Cathepsin C Proteins (CTSC)

The protein encoded by CTSC, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. Additionally we are shipping Cathepsin C Antibodies (80) and Cathepsin C Kits (28) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CTSC 1075 P53634
CTSC 13032 P97821
CTSC 25423 P80067
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Top Cathepsin C Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$827.20
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$844.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Dog His tag   1 mg Log in to see 56 to 66 Days
$2,203.67
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$2,205.50
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,205.50
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,205.50
Details

CTSC Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced Cathepsin C Proteins

  1. Human CTSC Protein expressed in Human Cells - ABIN2002945 : Cigi?, Dahl, Pain: The residual pro-part of cathepsin C fulfills the criteria required for an intramolecular chaperone in folding and stabilizing the human proenzyme. in Biochemistry 2000 (PubMed)
    Show all 5 references for ABIN2002945

More Proteins for Cathepsin C (CTSC) Interaction Partners

Human Cathepsin C (CTSC) interaction partners

  1. Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases.

  2. CTSC was associated with albuminuria in type 2 diabetes patients.

  3. Homozygous mutation 901G>A in exon 7 of CTSC gene is associated with Papillon-Lefevre syndrome.

  4. Results identify a missense mutation in CTSC gene that segregate within a family with Papillon-Lefevre syndrome.

  5. Papillon-Lefevre syndrome cause by homozygous nonsense mutation of cathepsin C gene.

  6. CatC has a role in the selective tuning of innate and adaptive immune responses, relevant to a chronic immune disease, such as atherosclerosis.

  7. cathepsin C in GCF (show GUCY2F Proteins) does not seem to have an effect on the pathogenesis of periodontal diseases.

  8. The present account of the 148.621 kb homozygous deletion on chromosome 11 is the first report of a mutational mechanism encompassing the whole CTSC gene.

  9. CTSC mutations in 5 Iranian families with Papillon-Lefevre syndrome (PLS)analyzed; modeled the protein for mutations found in 2 of them; presence of this mutation provides evidence for founder CTSC mutations in PLS; this P35delL mutation leads to loss of a leucine residue; results indicate the phenotypes in these 2 patients likely due to CTSC mutations

  10. Report novel deletion mutation in CTSC gene in Hungarian family with Papillon-Lefevre syndrome.

Mouse (Murine) Cathepsin C (CTSC) interaction partners

  1. Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases.

  2. Double immunofluorescence analysis showed that CTLA-2alpha was co-localized with cathepsin L (show CTSL1 Proteins), cathepsin C, and TINAGL1 (show TINAGL1 Proteins) in placenta.

  3. CatC has a role in the selective tuning of innate and adaptive immune responses, relevant to a chronic immune disease, such as atherosclerosis.

  4. Data indicate that all-trans retinoic acid (ATRA), which induces miR (show MLXIP Proteins)-23a expression, decreases cathepsin C (CTSC) expression and granzyme B activity leading to impaired NK cell cytotoxicity.

  5. These results establish that DPPI is a major determinant of survival following Klebsiella pneumoniae lung infection and suggest that the survival disadvantage in DPPI(+/+) mice is in part due to processing of surfactant protein D (show SFTPD Proteins) by DPPI.

  6. found no significant role for CtsC during mammary carcinogenesis but revealed squamous carcinogenesis to be functionally dependent on CtsC

  7. Late stage cathepsin C, CXCL13 (show CXCL13 Proteins) and Ki-67 (show MKI67 Proteins) overexpression correlate with regional neuropathology in a bovine spongiform encephalopathy transgenic murine model.

  8. Proinflammatory cytokines induce expression and release of cathepsin C in microglial cells during neuroinflammatory progression.

  9. The production of IL-1beta (show IL1B Proteins) by macrophages, neutrophils, and mast cells in vitro is dependent on caspase-1 (show CASP1 Proteins) but not on cathepsin C.

  10. NADPH oxidase (show NOX1 Proteins) in antimicrobial host defense against A. fumigatus and B. cepacia, whereas the proteases neutrophil elastase (show ELANE Proteins), cathepsin G (show CTSG Proteins), and lysosomal cysteine protease cathepsin C/ dipeptidyl peptidase I are dispensable

Cathepsin C (CTSC) Protein Profile

Protein Summary

The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Cathepsin C Proteins (CTSC)

  • cathepsin C (ctsc)
  • cathepsin C (CTSC)
  • cathepsin C (TP03_0357)
  • cathepsin C (CMU_003360)
  • cathepsin C (TGME49_089620)
  • cathepsin C (NAEGRDRAFT_80477)
  • cathepsin C (NAEGRDRAFT_37577)
  • cathepsin C (Ctsc)
  • cathepsin C (LOC100101594)
  • cathepsin C (Smp_183330)
  • cathepsin J (Ctsj)
  • AI047818 protein
  • CATC protein
  • CATP protein
  • CatRLP protein
  • CPPI protein
  • Ctsp protein
  • DPP-I protein
  • DPP1 protein
  • DPPI protein
  • HMS protein
  • JP protein
  • JPD protein
  • MGC69126 protein
  • MGC107782 protein
  • PALS protein
  • PDON1 protein
  • PLS protein

Protein level used designations for Cathepsin C Proteins (CTSC)

cathepsin C , dipeptidyl peptidase 1 , dipeptidyl peptidase 1 isoform a preproprotein , DPPI , DPP-I , cathepsin J , Dipeptidyl-peptidase 1 , dipeptidyl peptidase I , dipeptidyl transferase , dipeptidyl-peptidase I , dipeptidyl-peptidase 1 , dipeptidylpeptidase 1 , Cat P , cathepsin L-related protein , cathepsin P , catlrp-p , gene/Cathepsin L-related protein

GENE ID SPECIES
380203 Xenopus laevis
407938 Xenopus (Silurana) tropicalis
451469 Pan troglodytes
705320 Macaca mulatta
3500364 Theileria parva strain Muguga
6997925 Cryptosporidium muris RN66
7899372 Toxoplasma gondii ME49
8851692 Naegleria gruberi strain NEG-M
8855504 Naegleria gruberi strain NEG-M
100172530 Pongo abelii
352958 Bos taurus
1075 Homo sapiens
13032 Mus musculus
25423 Rattus norvegicus
100101594 Oryctolagus cuniculus
100714387 Cavia porcellus
403458 Canis lupus familiaris
419014 Gallus gallus
101112686 Ovis aries
8346758 Schistosoma mansoni
26898 Mus musculus
29174 Rattus norvegicus
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