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The protein encoded by CDC27 shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2.
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Cdc27 directs cyclin D1 (show CCND1 Antibodies) to alternative degradation by anaphase promoting complex/cyclosome.
Data indicate that UBE2S and APC3 co-regulate the expression level of P21 at G2/M check point via the ubiquitin-proteasome system.
Cdc27 is a novel binding partner of Elmo1 (show ELMO1 Antibodies).Cdc27-Elmo1 (show ELMO1 Antibodies) has a cellular role independent from the Elmo-Dock1 (show DOCK1 Antibodies)-Rac (show AKT1 Antibodies) signal module.
miR (show MLXIP Antibodies)-27a could modulate proliferation and radiosensitivity of TNBC cells. CDC-27 is a direct target of miR (show MLXIP Antibodies)-27a and its downregulation conferred increased radioresistance of the cells.
These findings suggested that polymorphisms in cdc27 may contribute to the susceptibility of BC though functional studies are needed to further elucidate the underling mechanisms of the associations
The structures show how one APC16 binds asymmetrically to the symmetric APC3 dimer and, together with biochemistry and prior data, explain how APC16 recruits APC7 (show ANAPC7 Antibodies) to APC3.
Low cdc27 and high securin (show PTTG1 Antibodies) expression predict short survival for breast cancer patients.
Down-regulation of CDC27 protein is associated with radiation resistance.
Data indicate that additional density present in the anaphase-promoting complex (APC (show APC Antibodies)/C) structure, proximal to Apc3/Cdc27 of the (tetratricopeptide repeat) lobe, is assigned to the TPR subunit Apc7 (show ANAPC7 Antibodies), a subunit specific to vertebrate APC (show APC Antibodies)/C.
the biochemical, structural, and cellular determinants of the novel interaction between MCPH1 (show MCPH1 Antibodies) and Cdc27 and suggest that this interaction may occur within the larger context of MCPH1 (show MCPH1 Antibodies)-APC (show APC Antibodies)/C.
phosphorylation of Cdc27 by CKII (show CSNK2A1 Antibodies) is involved in TGF-beta (show TGFB1 Antibodies)-induced activation of APC (show APC Antibodies).
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
cell division cycle 27 homolog
, cell division cycle protein 27 homolog
, cell division cycle protein 27
, CDC27 homolog
, anaphase promoting complex subunit 3
, anaphase-promoting complex subunit 3
, anaphase-promoting complex, protein 3
, nuc2 homolog