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CEP152 encodes a protein that is thought to be involved with centrosome function.
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Human Polyclonal CEP152 Primary Antibody for IHC, ELISA - ABIN1534750
Andersen, Wilkinson, Mayor, Mortensen, Nigg, Mann: Proteomic characterization of the human centrosome by protein correlation profiling. in Nature 2003
both mouse and human Cep63 (show CEP63 Antibodies) and Cep152 cooperate to ensure efficient centriole duplication by promoting the accumulation of essential centriole duplication factors upstream of SAS-6 (show SASS6 Antibodies) recruitment and procentriole formation.
Plk4 (show PLK4 Antibodies) is intricately regulated in time and space through ordered interactions with two distinct scaffolds, Cep192 and Cep152, and a failure in this process may lead to human cancer.
Found that both sc-54 and ab18 antibodies recognize not only Cdk1 (show CDK1 Antibodies) but also Cep152 in Western blot and immunofluorescence assays.
Loss of the Cep192- or Cep152-dependent interaction with Plk4 (show PLK4 Antibodies) resulted in impaired centriole duplication that led to delayed cell proliferation.
cooperation between Cep192 and Cep152 is crucial for centriole recruitment of Plk4 (show PLK4 Antibodies) and centriole duplication during the cell cycle.
Cep57 (show CEP57 Antibodies), Cep63 (show CEP63 Antibodies), and Cep152 are parts of a ring-like complex localizing around the proximal end of centrioles.
CEP152 is a genome maintenance protein disrupted in Seckel syndrome
Results suggest that Cep152 recruits Plk4 (show PLK4 Antibodies) and CPAP (show CENPJ Antibodies) to the centrosome to ensure a faithful centrosome duplication process.
Data show that Cep152 can be phosphorylated by Plk4 (show PLK4 Antibodies) in vitro, suggesting that Cep152 acts with Plk4 (show PLK4 Antibodies) to initiate centriole formation.
Drosophila Asl (show ADSL Antibodies) and human CEP152 are required for the centrosomal loading of Plk4 (show PLK4 Antibodies) in Drosophila and CPAP (show CENPJ Antibodies) in human cells, respectively
This gene encodes a protein that is thought to be involved with centrosome function. Mutations in this gene have been associated with primary microcephaly (MCPH4). Alternative splicing results in multiple transcript variants.
centrosomal protein 152kDa
, centrosomal protein of 152 kDa
, microcephaly, primary autosomal recessive 4