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CXCR3 encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Additionally we are shipping CXCR3 Antibodies (248) and CXCR3 Kits (40) and many more products for this protein.
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CXCR3 expression in chronic lymphocytic leukemia cells was a strong determinant of a worse clinical outcome.
Speculate that aberrant expression of CXCR3 in marginal zone lymphoma of the skin is associated with migration of lymphoma cells to the epidermis and could lead to an epidermotropic pattern.
CXCR3 role in autoimmune thyroiditis [review]
Both CXCL10 (show CXCL10 Proteins) and CXCR3 appeared to be useful in differentiating T1R reaction in borderline leprosy while CXCR3 alone differentiated BT from BT-T1R
CXCR3 expression was upregulated in advanced gastric cancer and was associated with increased CD4 (show CD4 Proteins)+, CD8 (show CD8A Proteins)+ tumor-infiltrating lymphocyte infiltration and improved overall survival
CXCR3 was also linked to steatosis through inducing hepatic lipogenic genes
congruent with the concept that inflammation plays a key role in the pathogenesis of LV dysfunction, MIG, IP10 and I-TAC add diagnostic accuracy over and beyond NT-pro BNP.
Suggest that aberrant CXCR3 expression may play crucial roles in suppressing prostate carcinoma metastasis by inhibiting cell proliferation and invasion through the PCLbeta signaling pathway.
The expression of the chemokine receptors CXCR3, CXCR4 and CXCR7 and their ligands.
This study is aimed at the optimization of a new analytical method for metabolic profiling with parallel bioaffinity assessment of CXCR3 ligands of the azaquinazolinone and piperazinyl-piperidine class and their metabolites.
CXCR3 interacts with IL-10 (show IL10 Proteins) secreted by CD8 (show CD8A Proteins)+CD122 (show IL2RB Proteins)+ regulatory T cells in a mouse model of Acute Lung Injury and promotes interferon-gamma (show IFNG Proteins) and CXCL10 (show CXCL10 Proteins) release.
This study demonstrates a previously unrecognized role of CXCR3 signaling in glial cells in negatively regulating Th17 cell expansion during experimental autoimmune encephalomyelitis
findings demonstrate that targeting CXCR3 is effective in both tumor and host compartments, and suggest that CXCR3 inhibition is likely to avoid adverse effects on host cells
Activation of the CXCL10 (show CXCL10 Proteins)/CXCR3 pathway has an important role in retinal inflammation and neuronal injury after high intraocular pressure-induced ischemia.
STAT3 (show STAT3 Proteins) in CD8 (show CD8A Proteins)+ T Cells Inhibits Their Tumor Accumulation by Downregulating CXCR3/CXCL10 (show CXCL10 Proteins) Axis
CXCR3-mediated trafficking of regulatory T cells could represent a mechanism of homeostatic immunoregulation during diabetogeneesis.
These studies identify CXCR3-mediated trafficking at the tumour vascular interface as a critical checkpoint to effective T-cell-based cancer immunotherapy.
activated T cells display a subtle distance-dependent chemotaxis toward clusters of infected cells and this is mediated by CXCR3 and its ligands.
results suggest that CXCR3 plays an important role in recruiting proinflammatory cells to the colon during colitis and that CXCR3 may be a therapeutic target to reduce the influx of proinflammatory cells in the inflamed colon.
Transcript analysis showed that antigen stimulation of WC1(+)gammadelta T cells substantially increased CXCR3 expression
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716).
chemokine (C-X-C motif) receptor 3
, C-X-C chemokine receptor type 3
, G protein-coupled receptor 9
, IP-10 receptor
, IP10 receptor
, Mig receptor
, chemokine (C-X-C) receptor 3
, interferon-inducible protein 10 receptor
, CXC chemokine receptor 3
, Interferon-inducible protein 10 receptor