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CLCN2 encodes a voltage-gated chloride channel. Additionally we are shipping Chloride Channel 2 Antibodies (56) and many more products for this protein.
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Identification and characterization of the zebrafish ClC (show CLCF1 Proteins)-2a/b/c chloride channel (show CLCA1 Proteins) orthologs.
Genetic ablation of ClC-2 resulted in reduced gastric gland region, reduced parietal cell number, reduced H/K ATPase (show ATP4b Proteins), reduced tubulovesicles and reduced stimulated acid secretion.
Data indicate that membrane protein MLC1 is crucial for proper localization of adhesion molecule (show NCAM1 Proteins) GlialCAM (show HEPACAM Proteins) and chloride channel (show CLCA1 Proteins) ClC-2, and for changing ClC-2 currents.
Loss of ClC-2 is associated with increased development of DSS (show PMP22 Proteins)-induced colitis.
The PCR data revealed the existence of two astrocytic subpopulations markedly differing in their gene expression levels for inwardly rectifying K+ channels (Kir4.1 (show KCNJ10 Proteins)), K(2P) channels (TREK-1 (show KCNK2 Proteins) and TWIK-1 (show KCNK1 Proteins)) and Cl- channels (ClC2).
ClC-2 channels are required for colonic electroneutral absorption of NaCl and KCl.
permeant Cl(-) ions contribute to V(m)-dependent gating of the broadly distributed ClC-2 Cl() channel.
GABAA (show GABRg1 Proteins) receptor-mediated synaptic inputs from basket cells were modulated by ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons.
ClC-2 reduces barrier function in normal mucosa. Ultrastructural morphology of tight junctions and myosin light chain kinase (show MYLK Proteins) appear to be important to the function of ClC-2 in normal mucosa.
these findings raise the possibility that ClC-2 expression plays a subtle neuroprotective role in the aging hippocampus
Heterozygous nmf240 mice present with a reduced electroretinography light peak component suggests that CLCN2 is necessary for the generation of this response component.
ClC-2-mediated intestinal Cl - secretion restores transepithelial resistance in ischemia-injured intestine.
The extracellular domain of GlialCAM (show HEPACAM Proteins) is necessary for cell junction targeting and for mediating interactions with itself or with MLC1 and ClC-2.
both ubiquitous (AP-1A) and epithelium-specific (AP-1B) forms of the tetrameric clathrin adaptor AP-1 (show FOSB Proteins) are capable of carrying out basolateral sorting of ClC-2.
SPAK (show STK39 Proteins) and OSR1 (show OXSR1 Proteins) are powerful negative regulators of the cell volume regulatory Cl- channel ClC-2
Correlation between CLC-2 gene expression and the cytoskeleton in human trabecular meshwork cells.
Our observations substantiate the concept that ClC-2 is involved in brain ion and water homoeostasis
JAK2 (show JAK2 Proteins) down-regulates ClC-2 activity and thus counteracts Cl(-) exit, an effect which may impact on cell volume regulation
This study demonistrated that the first auxiliary subunit of ClC-2 and suggests that ClC-2 may play a role in the pathology of MLC disease.
ClC-2 plays an important role in the modulation of tight junctions by influencing caveolar trafficking of tight junction protein occludin (show OCLN Proteins).
Sequence analysis of CLCN2 at genomic DNA and cDNA levels in 18 megalencephalic leukoencephalopathy MLC1 mutations revealed some nucleotide changes, but they were predicted to be nonpathogenic.
found significant expression of ClC-2 at the apex (show APEX1 Proteins) of ciliated cells in both rat and human airways
This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene.
chloride channel 2
, novel protein similar to vertebrate chloride channel 2 (CLCN2)
, chloride channel protein 2
, PKA-activated chloride channel ClC-2G