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CBX5 encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. Additionally we are shipping CBX5 Antibodies (272) and CBX5 Kits (1) and many more products for this protein.
Showing 7 out of 8 products:
Identify a nucleosome interaction module within KDM2A (show KDM2A Proteins) consisting of a CXXC type zinc finger, a PHD (show PDC Proteins) domain and a newly identified Heterochromatin Protein 1 (HP1 (show DEFA1 Proteins)) interaction motif that mediates direct binding between KDM2A (show KDM2A Proteins) and HP1 (show DEFA1 Proteins). This nucleosome interaction module enables KDM2A (show KDM2A Proteins) to decode nucleosomal H3K9me3 modification in addition to CpG methylation signals.
These data suggests that up-regulated HP1A (show TFF1 Proteins) and H3K9me3 in glioma cells are functionally associated with glioma pathogenesis and progression.
Loss of HP1alpha and gamma isoforms inhibits the upregulation of Suv39h1 (show SUV39H1 Proteins) and H3K9me3 that is observed under stress conditions.
we showed the essential role of HP1 (show DEFA1 Proteins) in regulating HR through BRCA1/BARD1 (show BARD1 Proteins)-mediated accumulation of FANCJ and CtIP (show RBBP8 Proteins) at DSB sites. This mechanism may affect tumorigenesis and chemosensitivity and is thus of high clinical significance.
We demonstrate that an hnRNPA1 (show HNRNPA1 Proteins) and CBX5 bi-directional core promoter fragment does not comprise intrinsic capacity for specific CBX5 down-regulation in metastatic cells
HP1alpha plays an important role in the differentiation and angiogenic function of Endothelial Progenitor Cells.
Jra recruits the HP1a (show TFF1 Proteins)/KDM4A (show KDM4A Proteins) complex to its gene body region upon osmotic stress to reduce H3K36 methylation levels and disrupt H3K36 methylation-dependent histone deacetylation
SET interacts with the Kruppel-associated box (KRAB)-associated co-repressor KAP1 (show CDKN3 Proteins), and its overexpression results in the sustained retention of KAP1 (show CDKN3 Proteins) and Heterochromatin protein 1 (HP1 (show DEFA1 Proteins)) on chromatin
HP1 (show DEFA1 Proteins) regulates this gene's alternative splicing in a methylation-dependent manner by recruiting splicing factors to its methylated form.
PIP5K1A (show PIP5K1A Proteins) modulates ribosomal RNA gene silencing through its interaction with histone H3 (show HIST3H3 Proteins) lysine 9 trimethylation and heterochromatin protein HP1-alpha.
HP1-alpha oligomerization is critical to the maintenance of heterochromatin and the tunable dynamics of this HP1 isoform.
demonstrate an actin-driven differential modulation of core histone H2B and heterochromatin HP1alpha protein dynamics with chromatin
the molecular behavior of HP1alpha throughout the cell cycle
There is a functional link between prelamin A, HP1alpha, chromatin remodeling, DNA repair, and early senescence in Zmpste24 (show Zmpste24 Proteins)-deficient mice, suggesting a potential therapeutic strategy for laminopathy-based premature aging via the intervention of HP1alpha.
the TIF1beta (show TRIM28 Proteins)-HP1 system functions as a critical repressive machinery that targets genes not normally activated in the hematopoietic compartment, thereby maintaining the transcriptional signature specific to HSCs.
HP1 mobility in apoptotic cells appeared to be unique.
Elimination of HP1alpha by siRNA interfered with centromere relocation from heterochromatin surrounding NPBs to pro-chromocenters at the two-cell stage but did not affect preimplantation develoment to the blastocyst stage.
Depletion of Senp7 (show SENP7 Proteins) delocalizes HP1 alpha from pericentric heterochromatin without affecting H3K9me3 levels.
The interplay between MU2 (show AP2M1 Proteins) and HP1a is dynamic and may be different in euchromatin and heterochromatin during DNA break recognition and repair.
KAP1 (show TRIM28 Proteins) and HP1 tether activation-induced cytidine deaminase (show AICDA Proteins) (AID) to H3K9me3 residues at the donor switch region, thus linking AID to epigenetic modifications during class switch recombination.
Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.
HP1 alpha homolog
, HP1Hs alpha
, antigen p25
, chromobox homolog 5 (HP1 alpha homolog, Drosophila)
, chromobox protein homolog 5
, heterochromatin protein 1 homolog alpha
, heterochromatin protein 1-alpha
, chromobox-like protein 5
, chromobox-like protein 5 (HP1 alpha homolog, Drosophila)
, neutrophil defensin 1
, HP1 alpha
, chromobox homolog 5
, heterochromatin protein 1 alpha
, chromobox homolog 5 tv3