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Chromobox Homolog 5 Proteins (CBX5)

CBX5 encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. Additionally we are shipping CBX5 Antibodies (248) and CBX5 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CBX5 12419 Q61686
CBX5 23468 P45973
Rat CBX5 CBX5 300266  
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Top CBX5 Proteins at

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

CBX5 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,

Top referenced CBX5 Proteins

  1. Human CBX5 Protein expressed in Escherichia coli (E. coli) - ABIN1098231 : Verreault, Kaufman, Kobayashi, Stillman: Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4. in Cell 1996 (PubMed)
    Show all 2 references for ABIN1098231

More Proteins for Chromobox Homolog 5 (CBX5) Interaction Partners

Mouse (Murine) Chromobox Homolog 5 (CBX5) interaction partners

  1. HP1-alpha oligomerization is critical to the maintenance of heterochromatin and the tunable dynamics of this HP1 isoform.

  2. demonstrate an actin-driven differential modulation of core histone H2B and heterochromatin HP1alpha protein dynamics with chromatin

  3. the molecular behavior of HP1alpha throughout the cell cycle

  4. There is a functional link between prelamin A, HP1alpha, chromatin remodeling, DNA repair, and early senescence in Zmpste24 (show Zmpste24 Proteins)-deficient mice, suggesting a potential therapeutic strategy for laminopathy-based premature aging via the intervention of HP1alpha.

  5. the TIF1beta (show TRIM28 Proteins)-HP1 system functions as a critical repressive machinery that targets genes not normally activated in the hematopoietic compartment, thereby maintaining the transcriptional signature specific to HSCs.

  6. HP1 mobility in apoptotic cells appeared to be unique.

  7. Elimination of HP1alpha by siRNA interfered with centromere relocation from heterochromatin surrounding NPBs to pro-chromocenters at the two-cell stage but did not affect preimplantation develoment to the blastocyst stage.

  8. Depletion of Senp7 (show SENP7 Proteins) delocalizes HP1 alpha from pericentric heterochromatin without affecting H3K9me3 levels.

  9. The interplay between MU2 (show AP2M1 Proteins) and HP1a is dynamic and may be different in euchromatin and heterochromatin during DNA break recognition and repair.

  10. KAP1 (show TRIM28 Proteins) and HP1 tether activation-induced cytidine deaminase (show AICDA Proteins) (AID) to H3K9me3 residues at the donor switch region, thus linking AID to epigenetic modifications during class switch recombination.

Human Chromobox Homolog 5 (CBX5) interaction partners

  1. we showed the essential role of HP1 (show DEFA1 Proteins) in regulating HR through BRCA1/BARD1 (show BARD1 Proteins)-mediated accumulation of FANCJ and CtIP (show RBBP8 Proteins) at DSB sites. This mechanism may affect tumorigenesis and chemosensitivity and is thus of high clinical significance.

  2. We demonstrate that an hnRNPA1 (show HNRNPA1 Proteins) and CBX5 bi-directional core promoter fragment does not comprise intrinsic capacity for specific CBX5 down-regulation in metastatic cells

  3. HP1alpha plays an important role in the differentiation and angiogenic function of Endothelial Progenitor Cells.

  4. Jra recruits the HP1a (show TFF1 Proteins)/KDM4A (show KDM4A Proteins) complex to its gene body region upon osmotic stress to reduce H3K36 methylation levels and disrupt H3K36 methylation-dependent histone deacetylation

  5. SET interacts with the Kruppel-associated box (KRAB)-associated co-repressor KAP1 (show CDKN3 Proteins), and its overexpression results in the sustained retention of KAP1 (show CDKN3 Proteins) and Heterochromatin protein 1 (HP1 (show DEFA1 Proteins)) on chromatin

  6. HP1 (show DEFA1 Proteins) regulates this gene's alternative splicing in a methylation-dependent manner by recruiting splicing factors to its methylated form.

  7. PIP5K1A (show PIP5K1A Proteins) modulates ribosomal RNA gene silencing through its interaction with histone H3 (show HIST3H3 Proteins) lysine 9 trimethylation and heterochromatin protein HP1-alpha.

  8. Paternal heterochromatin formation in human embryos is H3K9/HP1 (show DEFA1 Proteins) directed and primed by sperm-derived histone modifications.

  9. a considerable number of alternative splicing events could have a chromatin-dependent regulation involving the association of HP1alpha and CTCF (show CTCF Proteins) near regulated exons.

  10. Identify a nuclear localization signal within the 462-494 amino acid region of TRIM28 (show TRIM28 Proteins) that overlaps with its HP1 (show DEFA1 Proteins) binding site. GST (show SLCO6A1 Proteins)-pulldown experiments revealed the interaction of the arginine-rich TRIM28 (show TRIM28 Proteins) NLS (show ALDH1A2 Proteins) with various importin alpha (show KPNA4 Proteins) subtypes.

CBX5 Protein Profile

Protein Summary

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene names and symbols associated with Chromobox Homolog 5 Proteins (CBX5)

  • chromobox homolog 5 (HP1 alpha homolog, Drosophila) (cbx5)
  • chromobox homolog 5 (HP1 alpha homolog, Drosophila) (CBX5)
  • chromobox homolog 5 (cbx5)
  • chromobox 5 (Cbx5)
  • chromobox homolog 5 (CBX5)
  • chromobox homolog 5 (Cbx5)
  • 2610029O15Rik protein
  • C75991 protein
  • cbx5 protein
  • HP1 protein
  • HP1A protein
  • Hp1alpha protein
  • id:ibd2026 protein
  • MGC64354 protein
  • wu:fc63e02 protein
  • wu:fe47g12 protein
  • wu:fi03h05 protein
  • zgc:158601 protein

Protein level used designations for Chromobox Homolog 5 Proteins (CBX5)

chromobox protein homolog 5 , fc63e02 , chromobox homolog 5 (HP1 alpha homolog, Drosophila) , chromobox-like protein 5 (HP1 alpha homolog, Drosophila) , HP1 alpha , chromobox homolog 5 , heterochromatin protein 1 alpha , heterochromatin protein 1 homolog alpha , mHP1(alpha) , HP1 alpha homolog , HP1-ALPHA , HP1Hs alpha , antigen p25 , heterochromatin protein 1-alpha , chromobox-like protein 5 , chromobox homolog 5 tv3

563396 Danio rerio
467011 Pan troglodytes
100307036 Ovis aries
380557 Xenopus laevis
394502 Xenopus (Silurana) tropicalis
12419 Mus musculus
23468 Homo sapiens
477593 Canis lupus familiaris
538885 Bos taurus
300266 Rattus norvegicus
100519426 Sus scrofa
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