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Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier (By similarity). Additionally we are shipping and many more products for this protein.
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Cow (Bovine) Polyclonal Cingulin Primary Antibody for IHC (fro), IF - ABIN113474
Langbein, Grund, Kuhn, Praetzel, Kartenbeck, Brandner, Moll, Franke: Tight junctions and compositionally related junctional structures in mammalian stratified epithelia and cell cultures derived therefrom. in European journal of cell biology 2002
Show all 5 references for ABIN113474
Cow (Bovine) Monoclonal Cingulin Primary Antibody for IHC (fro), IHC (p) - ABIN112233
Keon, Schäfer, Kuhn, Grund, Franke: Symplekin, a novel type of tight junction plaque protein. in The Journal of cell biology 1996
Show all 4 references for ABIN112233
Cingulin modulates barrier function in endothelium.
MgcRacGAP (show RACGAP1 Antibodies) colocalizes with CGN and CGNL1 (show CGNL1 Antibodies) at TJs and forms a complex and interacts directly in vitro with CGN and CGNL1 (show CGNL1 Antibodies).
Co-imunoprecipitation and confocal microscopy experiments also revealed the tight junction protein (show OCLN Antibodies) cingulin as a new interacting partner of Ubn-1 (show UBN1 Antibodies)
Results indicate that cells underwent EMT (show ITK Antibodies) exhibited overactive TGFbeta (show TGFB1 Antibodies) signaling and loss of expression of the CDH1 (show CDH1 Antibodies), CGN, CLDN4 (show CLDN4 Antibodies), and KLK10 (show KLK10 Antibodies) genes as a result of hypermethylation of their corresponding promoter regions.
Cingulin (KIAA1319 protein) is localized in the cytoplasmic domain of vertebrate epithelial tight junctions, and it interacts with other tight junction proteins such as ZO-1 (show TJP1 Antibodies), and with the actomyosin cytoskeleton.
the regulated cingulin-microtubule association has a specific role in tight junction-related epithelial morphogenesis that is sensitive to metabolic homeostasis-related AMPK (show PRKAA1 Antibodies) activity.
cingulin is dispensable for the structure and barrier function of tight junctions, and is embedded in signaling networks that control the expression of claudin-2 (show CLDN2 Antibodies).
Data show by immunofluorescence labeling that the cytoskeletal-associated protein cingulin, commonly found at tight junctions, is also localized at neuronal gap junctions throughout the central nervous system.
cingulin does not have a critical role in tight-junction formation, but gene expression and tight junction protein (show OCLN Antibodies) levels are altered by the cingulin mutation
Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier (By similarity).
, hypothetical protein LOC100145755