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anti-Clarin 1 (CLRN1) Antibodies

CLRN1 encodes a protein that contains a cytosolic N-terminus, multiple helical transmembrane domains, and an endoplasmic reticulum membrane retention signal, TKGH, in the C-terminus. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CLRN1 7401 P58418
Anti-Mouse CLRN1 CLRN1 229320 Q8K445
Anti-Rat CLRN1 CLRN1 261738  
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Top anti-Clarin 1 Antibodies at antibodies-online.com

Showing 7 out of 10 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-CLRN1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Human brain WB Suggested Anti-CLRN1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: Human brain 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated EIA, IHC (fro), WB   0.2 mL Log in to see 6 to 8 Days
$533.50
Details
Human Rabbit Un-conjugated IHC, WB   100 μL Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   100 μL Log in to see 5 to 6 Days
$320.60
Details
Human Rabbit Un-conjugated IHC, IHC (p)   0.1 mL Log in to see 8 to 11 Days
$439.69
Details
Human Rabbit Un-conjugated WB   20 μL Log in to see 6 to 9 Days
$191.63
Details

CLRN1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human ,


More Antibodies against Clarin 1 Interaction Partners

Zebrafish Clarin 1 (CLRN1) interaction partners

  1. The zebrafish clrn1-/- mutants reported here show that Clrn1 is an essential hair bundle protein.

  2. Clarin-1 is functionally important for mechanotransduction channel activity and for proper localization of synaptic components.

  3. In the retina, Clarin-1 localizes to lateral cell contacts between photoreceptors and is associated with the outer limiting membrane and subapical processes emanating from Muller glial cells.

Human Clarin 1 (CLRN1) interaction partners

  1. This is the first report of Usher syndrome type 3 with a CLRN1 gene mutation in Asian populations.

  2. Possible digenism could not be excluded in two families segregating genomic variations in both MYO7A (show MYO7A Antibodies) and USH2A (show USH2A Antibodies), and two families with CLRN1 and USH2A (show USH2A Antibodies).

  3. Two novel mutations in the CLRN1 gene, p.R207X and p.I168N, have been found in patients with Usher syndrome type 3.

  4. High-resolution measures of retinal structure demonstrate patterns of cone loss associated with CLRN1 mutations.

  5. Here we describe a novel deletion in CLRN1. Our data support previously reported intra familial variability in the clinical features of Usher syndrome type I and III.

  6. The complexity of the CLRN1 gene and the identification of multiple splice variants may partially explain why mutations in CLRN1 result in substantial variation in clinical phenotype.

  7. a role for clarin-1 in hair cell and photoreceptor cell synapses, as well as a common pathophysiological pathway for different Usher syndromes

  8. revised structure of USH3 gene: new translation start site, 5' untranslated region, and transcript encoding 232-amino acid protein; four new disease-causing mutations; identified mouse and rat orthologues, and two human paralogues on chromosomes 4 and 10

  9. USH3A and USH2A (show USH2A Antibodies) share patterns of rod and cone dysfunction and retinal structural abnormalities.

  10. clarin-1 has a role in the regulation and homeostasis of actin filaments

Mouse (Murine) Clarin 1 (CLRN1) interaction partners

  1. CLRN1 expression is potentially supported by a variety of retinal cells, and the right combination of AAV vector dose, promoter, and delivery method needs to be selected to develop safe therapies for USH3 disorder.

  2. Mutations that are Clrn1-/- biallelic cause visual defects when placed under A/J background.

  3. A novel synaptic Usher complex comprised of clarin-1 and specific isoforms of CDH23, PCDH15 and VLGR1, was identified.

  4. a role for clarin-1 in hair cell and photoreceptor cell synapses, as well as a common pathophysiological pathway for different Usher syndromes

  5. Clarin-1 ribozyme induced apoptosis of cochlear hair cells and cells of stria vascularis. Suggest role for apoptosis in progressin of Usher syndrome type 3.

  6. Clrn1 is necessary for hair cell function and associated neural activation.

  7. clarin-1 has a role in the regulation and homeostasis of actin filaments

  8. The subcellular localization of clarin-1 in hair cells and photoreceptors suggests it functions at both the basal and apical poles of neurosensoriepithelia.

  9. CLRN1 is unnecessary in the murine retina but essential for normal cochlear development and function.

Clarin 1 (CLRN1) Antigen Profile

Protein Summary

This gene encodes a protein that contains a cytosolic N-terminus, multiple helical transmembrane domains, and an endoplasmic reticulum membrane retention signal, TKGH, in the C-terminus. The encoded protein may be important in development and homeostasis of the inner ear and retina. Mutations within this gene have been associated with Usher syndrome type IIIa. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Gene names and symbols associated with anti-Clarin 1 (CLRN1) Antibodies

  • clarin 1 (clrn1) antibody
  • clarin 1 (CLRN1) antibody
  • clarin 1 (LOC100342214) antibody
  • clarin 1 (Clrn1) antibody
  • A130002D11Rik antibody
  • RP61 antibody
  • Ush3 antibody
  • Ush3a antibody
  • zgc:91933 antibody

Protein level used designations for anti-Clarin 1 (CLRN1) Antibodies

clarin-1 , clarin 1 , clarin-1-like , Usher syndrome type-3 protein , Usher syndrome 3A homolog , usher syndrome type-3 protein homolog , Usher syndrome type III A

GENE ID SPECIES
436944 Danio rerio
538836 Bos taurus
611756 Canis lupus familiaris
710133 Macaca mulatta
738468 Pan troglodytes
771718 Gallus gallus
100342214 Oryctolagus cuniculus
7401 Homo sapiens
229320 Mus musculus
261738 Rattus norvegicus
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