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Coagulation Factor C Homolog, Cochlin (Limulus Polyphemus) Proteins (COCH)

The protein encoded by COCH is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Additionally we are shipping Coagulation Factor C Homolog, Cochlin (Limulus Polyphemus) Antibodies (60) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat COCH COCH 362735  
COCH 12810 Q62507
COCH 1690 O43405
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Top Coagulation Factor C Homolog, Cochlin (Limulus Polyphemus) Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_CHO Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

COCH Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
,

Top referenced Coagulation Factor C Homolog, Cochlin (Limulus Polyphemus) Proteins

  1. Human COCH Protein expressed in Human Cells - ABIN2004241 : Kommareddi, Nair, Raphael, Telian, Kim, Arts, El-Kashlan, Carey: Cochlin isoforms and their interaction with CTL2 (SLC44A2) in the inner ear. in Journal of the Association for Research in Otolaryngology : JARO 2007 (PubMed)
    Show all 2 references for ABIN2004241

  2. Human COCH Protein expressed in CHO Cells - ABIN2004243 : Mizuta, Ikezono, Iwasaki, Arai, Hashimoto, Pawankar, Watanabe, Shindo, Mineta: Ultrastructural co-localization of cochlin and type II collagen in the rat semicircular canal. in Neuroscience letters 2008 (PubMed)
    Show all 2 references for ABIN2004243

More Proteins for Coagulation Factor C Homolog, Cochlin (Limulus Polyphemus) (COCH) Interaction Partners

Mouse (Murine) Coagulation Factor C Homolog, Cochlin (Limulus Polyphemus) (COCH) interaction partners

  1. accumulation of acellular deposits in the incudomalleal and incudostapedi (show EPRS Proteins)al joints in Coch (G88E/G88E) mice similar to those found in human DFNA9-affected temporal bones

  2. study reports that cochlin is expressed by follicular dendritic cells (FDCs) and selectively localized in the fine extracellular network of conduits in the spleen and lymph nodes; by producing cochlin, FDCs contribute to the innate immune response in defense against bacteria

  3. COCH is a part of the downstream target network of BMP4 (show BMP4 Proteins) signaling and serves as another important effector to fine-tune mouse embryonic stem cell fates.

  4. Loss of Cochlin is associated with reduced intraocular pressure and mechanosensing.

  5. In Coch knock-in/knockout mouse models of sensorineural hearing loss and vestibular dysfunction vestibular function is compromised before cochlear function.

  6. Up-regulation of cochlin is an important etiologic factor leading to Usher syndrome type 1F.

  7. Areas that express COCH mRNA as determined by in situ hybridization, and to the regions of the inner ear which show histological abnormalities in autosomal dominant sensorineural deafness and vestibular disorder, DFNA9.

  8. Cochlin was found in the trabecular meshwork of very young mice, prior to elevated intraocular pressure, suggesting that over time the protein may contribute to the events leading to increased IOP and optic nerve damage--{REVIEW}

  9. introduced the G88E mutation by gene targeting into the mouse and have created a Coch(G88E/G88E) mouse model for the study of DFNA9 pathogenesis and cochlin function

Guinea Pig Coagulation Factor C Homolog, Cochlin (Limulus Polyphemus) (COCH) interaction partners

  1. The full-length 1991 bp Coch cDNA that encodes a 553 amino acid protein was isolated; the sequence had significant homology with other mammals.

Human Coagulation Factor C Homolog, Cochlin (Limulus Polyphemus) (COCH) interaction partners

  1. the impaired post-translational cleavage of cochlin mutants may be associated with pathological mechanisms underlying DFNA9-related sensorineural hearing loss.

  2. This family is the first case of a truncating COCH variant and supports the hypothesis that COCH haploinsufficiency is not the cause of hearing loss in humans.

  3. Targeted exon resequencing of selected genes using next-generation sequencing identified 3 COCH (one known, two novel) mutations in a cohort of hearing loss patients in Japan.

  4. This is the first report showing failure of mutant cochlin transport through the secretory pathway, abolishment of cochlin secretion, and formation and retention of dimers and large multimeric intracellular aggregates

  5. prominent in the incudomalleal joint, incudostapedial joint, and the pars (show EPRS Proteins) tensa of the tympanic membrane

  6. A new phenotypic and characteristic radiologic feature of DFNA9 has been discovered.

  7. new variants in genes such as COCH is associated with nonsyndromic deafness and vestibular dysfunction.

  8. Chinese DFNA9 family associated with novel COCH mutation with genotype-phenotype correlation.

  9. This study suggests lack of association of both COCH and TNFA (show TNF Proteins) with primary open-angle glaucoma pathogenesis.

  10. COCH and SLC26A5 (show SLC26A5 Proteins) mRNA are expressed in specific structures and cells of the inner ear in archival human temporal bone

Coagulation Factor C Homolog, Cochlin (Limulus Polyphemus) (COCH) Protein Profile

Protein Summary

The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated.

Gene names and symbols associated with COCH

  • cochlin (Coch)
  • coagulation factor C homolog (Limulus polyphemus) (Coch)
  • coagulation factor C homolog, cochlin (Limulus polyphemus) (COCH)
  • cochlin (COCH)
  • AW122937 protein
  • COCH-5B2 protein
  • COCH5B2 protein
  • D12H14S564E protein
  • DFNA9 protein

Protein level used designations for COCH

coagulation factor C homolog (Limulus polyphemus) , coagulation factor C homolog, cochlin (Limulus polyphemus) , cochlin , Coch-5B2

GENE ID SPECIES
362735 Rattus norvegicus
12810 Mus musculus
100174920 Cavia porcellus
504316 Bos taurus
395779 Gallus gallus
1690 Homo sapiens
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