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F3 encodes coagulation factor III which is a cell surface glycoprotein. Additionally we are shipping Coagulation Factor III (thromboplastin, Tissue Factor) Antibodies (189) and Coagulation Factor III (thromboplastin, Tissue Factor) Kits (93) and many more products for this protein.
Showing 10 out of 33 products:
Human F3 Protein expressed in Escherichia coli (E. coli) - ABIN1098373
Bogdanov, Balasubramanian, Hathcock, Vele, Lieb, Nemerson: Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein. in Nature medicine 2003
Show all 2 references for ABIN1098373
Mouse (Murine) F3 Protein expressed in Human Cells - ABIN2007770
Kinev, Roubey: Tissue factor in the antiphospholipid syndrome. in Lupus 2008
Thrombin (show F2 Proteins)-independent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease.
These findings reveal a novel biological function and mechanism of the protein C (show PROC Proteins) pathway in which protein S and the aPC (show APC Proteins)-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC (show APC Proteins) in the context of endotoxemia and infection
Lung epithelial tissue factor regulates alveolar procoagulant activity and permeability in acute lung injury.
PGE2 increases both TF expression and activity through the regulation of the EP1 (show PTGER1 Proteins)/SIRT1 (show SIRT1 Proteins) pathway.
Fas (show FAS Proteins)-initiated, caspase-3 (show CASP3 Proteins)-dependent hepatocyte apoptosis increases tissue factor procoagulant activity through a mechanism involving phosphatidylserine externalization.
Heme promotes tissue factor-dependent coagulation activation and induces tissue factor expression on leukocytes in vivo.
TF is essential for the development of pericyte coverage of tumor microvessels and aPL (show FASL Proteins)-induced tumor cell expression of chemokine ligand 2 (show CXCL2 Proteins), a mediator of pericyte recruitment
Alternatively spliced tissue factor promotes plaque angiogenesis through the activation of hypoxia-inducible factor-1alpha and vascular endothelial growth factor signaling.
Klkb1 (show KLKB1 Proteins)(-/-) mice have a novel mechanism for thrombosis protection in addition to reduced contact activation. This pathway arises when bradykinin delivery to vasculature is compromised and mediated by increased receptor Mas (show MAS1 Proteins), prostacyclin, Sirt1 (show SIRT1 Proteins), and KLF4 (show KLF4 Proteins)
study provides a novel mechanism for the posttranscriptional regulation of TF expression, indicating that this is selectively regulated by PARP-14.
Activation of P2Y2R (show P2RY2 Proteins) increased TF promoter activity and mRNA expression in coronary artery endothelial cells.
This study suggests that ROCK/YAP (show YAP1 Proteins)/Egr-1 (show EGR1 Proteins) signaling regulates tissue factor expression after stimulation with lipopolysaccharide in endothelial cells.
Soluble Tissue Factor" in the 21st Century: Definitions, Biochemistry, and Pathophysiological Role in Thrombus Formation.
The Role of Tissue Factor in Atherothrombosis and Coronary Artery Disease: Insights into Platelet Tissue Factor.
Structure-Function Relationship of the Interaction between Tissue Factor and Factor VIIa.
Tissue Factor Expressed by Neutrophils
Clinical Significance of Tissue Factor-Exposing Microparticles in Arterial and Venous Thrombosis.
Data suggest that allosteric regulation of FVIIa activity by tissue factor/thromboplastin binding appear to involve direct interaction with FVIIa active site, stabilizing segment 215-217, activating loop 3, and leading to enhanced FVIIa activity.
Data indicate that IGF-binding protein 3 (IGFBP3 (show IGFBP3 Proteins)) and F3 gene expression levels in formalin fixed paraffin embedded (FFPE) prostate cancer tissue would provide an improved survival prediction for prostate cancer patients.
asTF expression was associated with grade and stage in ER-positive breast tumors only. Tissue factor isoform and estrogen signaling share downstream targets in BrCa; concomitant asTF and estrogen signaling is required for BrCa cell proliferation.
Arterial (18)F-fluorodeoxyglucose uptake reflects balloon catheter-induced thrombus formation and tissue factor expression via nuclear factor-kappaB in rabbit atherosclerotic lesions.
Polycations could present a new class of anticoagulants with such unique upstream downregulation of blood coagulation, selectively blocking tissue factor-dependent factor VII (show TH Proteins) activation.
Upregulated TF expression and increased plasma TF level during reperfusion period, reduced plasma TFPI-1 (show TFPI Proteins) level during reperfusion period.
lectin-like oxidized LDL receptor (show OLR1 Proteins) Oxidized low-density lipoprotein receptor (show LDLR Proteins) 1expression appears to be closely associated with tissue factor expression, apoptotic events and morphological vulnerability in atherosclerotic lesions
Tissue factor expression on porcine neonatal islet cell clusters is an important initiator of instant blood-mediated inflammatory reaction in islet xenotransplantation.
Prolonged clopidogrel treatment reduced coronary tissue factor (TF) expression and tended to reduce the blood TF level post-PCI (show SERPINA5 Proteins), thus possibly modulating the risk of late thrombosis.
Procoagulant porcine tissue factor is induced in primary pig aortic endothelial cells only by fresh human plasma, and not by heat-inactivated plasma.
myocardial infarction induced proinflammatory gene and protein expression in peripheral blood mononuclear cells of tissue factor cyclo-oxygenase-2, monocyte chemoattractant protein-1 (show CCL2 Proteins) and CRP (show CRP Proteins)
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.
, coagulation factor III
, tissue factor
, brain tissue factor
, coagulation factor 3