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Coagulation Factor III (thromboplastin, Tissue Factor) Proteins (F3)

F3 encodes coagulation factor III which is a cell surface glycoprotein. Additionally we are shipping Coagulation Factor III (thromboplastin, Tissue Factor) Antibodies (189) and Coagulation Factor III (thromboplastin, Tissue Factor) Kits (93) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
F3 14066 P20352
F3 2152 P13726
F3 25584  
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Top Coagulation Factor III (thromboplastin, Tissue Factor) Proteins at

Showing 10 out of 33 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Rabbit His tag,ECD 10 μg Log in to see 16 Days
HOST_Human Cells Mouse His tag 10 μg Log in to see 16 Days
HOST_Human Cells Human His tag 10 μg Log in to see 16 Days
HOST_Human Cells Rat His tag 10 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Human His tag 20 μg Log in to see 7 to 8 Days
HOST_Escherichia coli (E. coli) Cow His tag,T7 tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days

F3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Human , , ,
Rat (Rattus) ,

Top referenced Coagulation Factor III (thromboplastin, Tissue Factor) Proteins

  1. Human F3 Protein expressed in Escherichia coli (E. coli) - ABIN1098373 : Bogdanov, Balasubramanian, Hathcock, Vele, Lieb, Nemerson: Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein. in Nature medicine 2003 (PubMed)
    Show all 2 references for ABIN1098373

  2. Mouse (Murine) F3 Protein expressed in Human Cells - ABIN2007770 : Kinev, Roubey: Tissue factor in the antiphospholipid syndrome. in Lupus 2008 (PubMed)

More Proteins for Coagulation Factor III (thromboplastin, Tissue Factor) (F3) Interaction Partners

Mouse (Murine) Coagulation Factor III (thromboplastin, Tissue Factor) (F3) interaction partners

  1. Thrombin (show F2 Proteins)-independent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease.

  2. These findings reveal a novel biological function and mechanism of the protein C (show PROC Proteins) pathway in which protein S and the aPC (show APC Proteins)-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC (show APC Proteins) in the context of endotoxemia and infection

  3. Lung epithelial tissue factor regulates alveolar procoagulant activity and permeability in acute lung injury.

  4. PGE2 increases both TF expression and activity through the regulation of the EP1 (show PTGER1 Proteins)/SIRT1 (show SIRT1 Proteins) pathway.

  5. Fas (show FAS Proteins)-initiated, caspase-3 (show CASP3 Proteins)-dependent hepatocyte apoptosis increases tissue factor procoagulant activity through a mechanism involving phosphatidylserine externalization.

  6. Heme promotes tissue factor-dependent coagulation activation and induces tissue factor expression on leukocytes in vivo.

  7. TF is essential for the development of pericyte coverage of tumor microvessels and aPL (show FASL Proteins)-induced tumor cell expression of chemokine ligand 2 (show CXCL2 Proteins), a mediator of pericyte recruitment

  8. Alternatively spliced tissue factor promotes plaque angiogenesis through the activation of hypoxia-inducible factor-1alpha and vascular endothelial growth factor signaling.

  9. Klkb1 (show KLKB1 Proteins)(-/-) mice have a novel mechanism for thrombosis protection in addition to reduced contact activation. This pathway arises when bradykinin delivery to vasculature is compromised and mediated by increased receptor Mas (show MAS1 Proteins), prostacyclin, Sirt1 (show SIRT1 Proteins), and KLF4 (show KLF4 Proteins)

  10. study provides a novel mechanism for the posttranscriptional regulation of TF expression, indicating that this is selectively regulated by PARP-14.

Human Coagulation Factor III (thromboplastin, Tissue Factor) (F3) interaction partners

  1. Activation of P2Y2R (show P2RY2 Proteins) increased TF promoter activity and mRNA expression in coronary artery endothelial cells.

  2. This study suggests that ROCK/YAP (show YAP1 Proteins)/Egr-1 (show EGR1 Proteins) signaling regulates tissue factor expression after stimulation with lipopolysaccharide in endothelial cells.

  3. Soluble Tissue Factor" in the 21st Century: Definitions, Biochemistry, and Pathophysiological Role in Thrombus Formation.

  4. The Role of Tissue Factor in Atherothrombosis and Coronary Artery Disease: Insights into Platelet Tissue Factor.

  5. Structure-Function Relationship of the Interaction between Tissue Factor and Factor VIIa.

  6. Tissue Factor Expressed by Neutrophils

  7. Clinical Significance of Tissue Factor-Exposing Microparticles in Arterial and Venous Thrombosis.

  8. Data suggest that allosteric regulation of FVIIa activity by tissue factor/thromboplastin binding appear to involve direct interaction with FVIIa active site, stabilizing segment 215-217, activating loop 3, and leading to enhanced FVIIa activity.

  9. Data indicate that IGF-binding protein 3 (IGFBP3 (show IGFBP3 Proteins)) and F3 gene expression levels in formalin fixed paraffin embedded (FFPE) prostate cancer tissue would provide an improved survival prediction for prostate cancer patients.

  10. asTF expression was associated with grade and stage in ER-positive breast tumors only. Tissue factor isoform and estrogen signaling share downstream targets in BrCa; concomitant asTF and estrogen signaling is required for BrCa cell proliferation.

Rabbit Coagulation Factor III (thromboplastin, Tissue Factor) (F3) interaction partners

  1. Arterial (18)F-fluorodeoxyglucose uptake reflects balloon catheter-induced thrombus formation and tissue factor expression via nuclear factor-kappaB in rabbit atherosclerotic lesions.

  2. Polycations could present a new class of anticoagulants with such unique upstream downregulation of blood coagulation, selectively blocking tissue factor-dependent factor VII (show TH Proteins) activation.

  3. Upregulated TF expression and increased plasma TF level during reperfusion period, reduced plasma TFPI-1 (show TFPI Proteins) level during reperfusion period.

  4. lectin-like oxidized LDL receptor (show OLR1 Proteins) Oxidized low-density lipoprotein receptor (show LDLR Proteins) 1expression appears to be closely associated with tissue factor expression, apoptotic events and morphological vulnerability in atherosclerotic lesions

Pig (Porcine) Coagulation Factor III (thromboplastin, Tissue Factor) (F3) interaction partners

  1. Tissue factor expression on porcine neonatal islet cell clusters is an important initiator of instant blood-mediated inflammatory reaction in islet xenotransplantation.

  2. Prolonged clopidogrel treatment reduced coronary tissue factor (TF) expression and tended to reduce the blood TF level post-PCI (show SERPINA5 Proteins), thus possibly modulating the risk of late thrombosis.

  3. Procoagulant porcine tissue factor is induced in primary pig aortic endothelial cells only by fresh human plasma, and not by heat-inactivated plasma.

  4. myocardial infarction induced proinflammatory gene and protein expression in peripheral blood mononuclear cells of tissue factor cyclo-oxygenase-2, monocyte chemoattractant protein-1 (show CCL2 Proteins) and CRP (show CRP Proteins)

Coagulation Factor III (thromboplastin, Tissue Factor) (F3) Protein Profile

Protein Summary

This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with F3

  • coagulation factor IIIa (f3a)
  • tissue factor (tf)
  • coagulation factor III (F3)
  • coagulation factor III (thromboplastin, tissue factor) (F3)
  • AA409063 protein
  • CD142 protein
  • Cf-3 protein
  • Cf3 protein
  • f3 protein
  • TF protein
  • TFA protein

Protein level used designations for F3

TFa , coagulation factor III , thromboplastin , tissue factor , TF , brain tissue factor , coagulation factor 3

567257 Danio rerio
100136035 Oncorhynchus mykiss
14066 Mus musculus
100135463 Cavia porcellus
280686 Bos taurus
2152 Homo sapiens
100009127 Oryctolagus cuniculus
25584 Rattus norvegicus
490153 Canis lupus familiaris
396677 Sus scrofa
429084 Gallus gallus
101118918 Ovis aries
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