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Coagulation Factor X Proteins (F10)

F10 encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. Additionally we are shipping Coagulation Factor X Antibodies (123) and Coagulation Factor X Kits (56) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
F10 14058 O88947
F10 2159 P00742
F10 29243 Q63207
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Top Coagulation Factor X Proteins at

Showing 10 out of 23 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag 10 μg Log in to see 20 to 21 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 50 μg Log in to see 9 to 11 Days
HOST_Mammalian Cells Mouse His tag   50 μg Log in to see 5 Days
HOST_Human Human Un-conjugated   1 mg Log in to see 2 to 3 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days

F10 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , , , ,
Human , , , ,
, ,
Rat (Rattus) ,

Top referenced Coagulation Factor X Proteins

  1. Human Coagulation Factor X Protein expressed in Baculovirus infected Insect Cells - ABIN2003917 : Fung, Hay, MacGillivray: Characterization of an almost full-length cDNA coding for human blood coagulation factor X. in Proceedings of the National Academy of Sciences of the United States of America 1985 (PubMed)

  2. Human Coagulation Factor X Protein expressed in Human - ABIN2544335 : Yang, Su, Ren, Chen: Synthesis of 3,4-diaminobenzoyl derivatives as factor Xa inhibitors. in European journal of medicinal chemistry 2015 (PubMed)

More Proteins for Coagulation Factor X (F10) Interaction Partners

Mouse (Murine) Coagulation Factor X (F10) interaction partners

  1. Macrophages regulate FX plasma levels in an SR-AI (show MSR1 Proteins)-dependent manner.

  2. Factor Xa has a role in inhibiting HMGB1 (show HMGB1 Proteins)-induced septic responses in human umbilical vein endothelial cells and in mice

  3. Selective inhibition of FXa improves the left ventricular function during CVB3-induced myocarditis and seems to be associated with an improved myocardial remodeling.

  4. Activated factor X signaling via protease-activated receptor 2 (show F2RL1 Proteins) suppresses pro-inflammatory cytokine production from lipopolysaccharide-stimulated myeloid cells.

  5. There was no detectable increase in plasma levels of mouse FX after active-site inhibited human APC (show APC Proteins) administration to mice overexpressing human EPCR (show PROCR Proteins). FX does not effectively interact with EPCR (show PROCR Proteins) in vivo, at least in regards to the mouse system.

  6. investigation of role of F10a in progression of diabetic nephropathy: data from studies using inhibitor of F10a suggest that F10a does play a role in development of proteinemia, glomerular hypertrophy, and protein deposition in kidney of db/db (show LEPR Proteins) mice

  7. Data suggest that tissue factor (show F3 Proteins) and factor V induction by LPS (show TLR4 Proteins) may in part accelerate mesangioproliferative glomerulonephritis through activation of factor X and downstream proinflammatory and procoagulant mechanisms.

  8. Gene targeting of tissue factor (show F3 Proteins), factor X, and factor VII (show TH Proteins) in mice: their involvement in embryonic development

  9. Factor Xa functions in airway remodeling in asthma by stimulating mucin (show SLC13A2 Proteins) production, through regulation of amphiregulin (show AREG Proteins) expression and collagen deposition.

  10. Results show that although factor Xa induces p42 (show EPB42 Proteins)/44 MAP Kinase (show MAPK1 Proteins) phosphorylation in endothelial cells, it has no direct effect on endothelial cell proliferation, protein synthesis and tube formation.

Human Coagulation Factor X (F10) interaction partners

  1. analysis of how physiological concentrations of Tissue factor pathway inhibitor (show TFPI Proteins) inhibit FXa

  2. According to our study, compounds 1a, 1g and 1s displayed evident FXa inhibitory activity and excellent selectivity over thrombin (show F2 Proteins) in in vitro inhibition activities studies.

  3. Large deletions play a minor but essential role in the mutational spectrum of the F7 and F10 genes. Copy number analyses (e. g. MLPA) should be considered if sequencing cannot clarify the underlying reason of an observed coagulopathy. Of note, in cases of combined FVII (show F7 Proteins)/FX deficiency, a deletion of the two contiguous genes might be part of a larger chromosomal rearrangement.

  4. homozygous mutation g.27881G>A(p.Val298Met) of the F10 gene has been identified, which probably accounts for the low FX concentrations in this pedigree

  5. Establish FXa as a potentially important asthma mediator, stimulating airway smooth muscle function through actions requiring PAR-1 (show MARK2 Proteins) and annexin A2 (show ANXA2 Proteins) and involving integrin coactivation.

  6. FXa may inhibit lipopolysaccharide-mediated expression of sPLA2-IIA (show PLA2G2A Proteins) by suppression of cytosolic phospholipase A2 (show PLA2G4A Proteins) and extracellular signal-regulated kinase 1/2 (show MAPK3 Proteins).

  7. Several members of a family had a c.112 G>C mutation in exon 2 of the F10 gene. Although in-silico analysis predicts this is a benign mutation, this family suggests that the amino acid substitution affects the properties of the factor X protein.

  8. Various acylcarnitines inhibited factor Xa-initiated clotting.

  9. The model of human prothrombinase presented here provides a powerful resource for contextualizing previous data and for designing future experiments

  10. Describe inhibition of tissue factor:factor VIIa-catalyzed factor IX and factor X activation by TFPI (show TFPI Proteins) and TFPI (show TFPI Proteins) constructs.

Cow (Bovine) Coagulation Factor X (F10) interaction partners

  1. Data suggest factor Xa (FXa) and factor Va (FVa) compete to bind FXa on both PS model membranes and microparticles from activated platelets; this competition between dimerization/prothrombinase (show FGL2 Proteins) complex formation appears to regulate blood coagulation.

  2. thrombin (show F2 Proteins) and factor Xa diffusion along the heparin molecule explains the effects of extended heparin chain lengths

  3. Factor Xa (fXa), a key serine protease (show F2 Proteins) of the coagulation system, was used as a model enzyme to test the canonical conformation hypothesis.

Coagulation Factor X (F10) Protein Profile

Protein Summary

This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds\; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.

Gene names and symbols associated with Coagulation Factor X Proteins (F10)

  • coagulation factor X (f10)
  • coagulation factor X precursor (F10)
  • coagulation factor X (F10)
  • coagulation factor X (CpipJ_CPIJ012712)
  • coagulation factor X (CpipJ_CPIJ014863)
  • coagulation factor X (CpipJ_CPIJ016937)
  • coagulation factor X (CpipJ_CPIJ017791)
  • Coagulation factor X (fa10)
  • coagulation factor X-like (F10)
  • Cf10 protein
  • F10 protein
  • fi12c10 protein
  • FX protein
  • FXA protein
  • wu:fi12c10 protein

Protein level used designations for Coagulation Factor X Proteins (F10)

coagulation factor 10 , coagulation factor X , vitamin K dependent serine protease , coagulation factor X preproprotein , Coagulation factor X , stuart factor , Stuart-Prower factor , factor Xa , prothrombinase , blood coagulation factor X , VAP , factor XA light chain , virus activating protease , virus-activating protease

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714132 Macaca mulatta
790961 Ornithorhynchus anatinus
6045845 Culex quinquefasciatus
6048453 Culex quinquefasciatus
6050511 Culex quinquefasciatus
6052088 Culex quinquefasciatus
100022394 Monodelphis domestica
100137443 Papio anubis
100380501 Salmo salar
100408094 Callithrix jacchus
100453258 Pongo abelii
100471482 Ailuropoda melanoleuca
100607918 Nomascus leucogenys
14058 Mus musculus
2159 Homo sapiens
476993 Canis lupus familiaris
100008647 Oryctolagus cuniculus
29243 Rattus norvegicus
100726878 Cavia porcellus
280787 Bos taurus
395876 Gallus gallus
101118624 Ovis aries
790178 Bos taurus
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