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The protein encoded by CFL1 can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Additionally we are shipping Cofilin 1 (Non-Muscle) Kits (58) and Cofilin 1 (Non-Muscle) Proteins (24) and many more products for this protein.
Showing 10 out of 274 products:
Human Monoclonal CFL1 Primary Antibody for IF, WB - ABIN394735
Garg, Verma, Cook, Soofi, Venkatareddy, George, Mizuno, Gurniak, Witke, Holzman: Actin-depolymerizing factor cofilin-1 is necessary in maintaining mature podocyte architecture. in The Journal of biological chemistry 2010
Show all 5 references for ABIN394735
Dog (Canine) Monoclonal CFL1 Primary Antibody for IF, WB - ABIN968754
Chan, Bailly, Zebda, Segall, Condeelis: Role of cofilin in epidermal growth factor-stimulated actin polymerization and lamellipod protrusion. in The Journal of cell biology 2000
Show all 3 references for ABIN968754
Human Polyclonal CFL1 Primary Antibody for IHC (p), WB - ABIN197372
Kobayashi, Nishita, Mishima, Ohashi, Mizuno: MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration. in The EMBO journal 2006
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Human Polyclonal CFL1 Primary Antibody for DB - ABIN650888
Klemke, Kramer, Konstandin, Wabnitz, Samstag: An MEK-cofilin signalling module controls migration of human T cells in 3D but not 2D environments. in The EMBO journal 2010
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Human Monoclonal CFL1 Primary Antibody for EIA, IHC (p) - ABIN336102
Mannherz, Ballweber, Galla, Villard, Granier, Steegborn, Schmidtmann, Jaquet, Pope, Weeds: Mapping the ADF/cofilin binding site on monomeric actin by competitive cross-linking and peptide array: evidence for a second binding site on monomeric actin. in Journal of molecular biology 2007
Show all 2 references for ABIN336102
Human Polyclonal CFL1 Primary Antibody for IF, IHC (p) - ABIN319381
Chen, Cizeau, Vande Velde, Park, Bozek, Bolton, Shi, Dubik, Greenberg: Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. in The Journal of biological chemistry 1999
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Human Polyclonal CFL1 Primary Antibody for ELISA, WB - ABIN1534356
Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. in Cell 2006
Human Polyclonal CFL1 Primary Antibody for FACS, WB - ABIN650759
Fazal, Bijli, Minhajuddin, Rein, Finkelstein, Rahman: Essential role of cofilin-1 in regulating thrombin-induced RelA/p65 nuclear translocation and intercellular adhesion molecule 1 (ICAM-1) expression in endothelial cells. in The Journal of biological chemistry 2009
Results suggest that elevation of actin dynamics by Xenopus ADF/cofilin (XAC) activation through Slingshot phosphatase (XSSH) phosphorylation is required for meiotic spindle assembly.
Gastrulation movement requires ADF/cofilin activity through dynamic regulation of its phosphorylation state.
proper actin turnover mediated by Cfl1 is essential for adhesion between the deep cell layer and the enveloping layer and cell movements during gastrulation in zebrafish
Silencing of cofilin-1 led to an Accumulation of F-actin fibers and significantly decreased podocyte migration. ability
Cofilin/Twinstar phosphorylation levels increase in response to impaired coenzyme a metabolism.
AIP1 enhances cofilin-mediated actin disassembly in the apical region of precluster cells to promote remodeling of adherense junctions.
Data show that cofilin is required for F-actin turnover and lamellipodial protrusion in the border cells.
tsr is required for planar cell polarity patterning.
These results indicate that changes in the extent of cofilin phosphorylation are regulated by Ssh in response to changes in the levels and/or organisation of F-actin.
Results show that twinstar (tsr), which encodes Drosophila cofilin/ADF (actin-depolymerizing factor), is required for elongation of the retinal cell body and the morphogenesis of the rhabdomere.
Aurora kinase A (show AURKA Antibodies) has a role in inducing papillary thyroid cancer lymph node metastasis by promoting cofilin-1 activity
analysis of human Cof1, Cof2, and ADF effects on actin filament severing and turnover
Cofilin 1 activation prevents the defects in axon elongation and guidance induced by extracellular alpha-synuclein (show SNCA Antibodies)
novel roles for actin-depolymerizing factor (show GSN Antibodies) and cofilin-1 in regulating the remodeling and permeability of epithelial junctions
cofilin1 is involved in hypertensive nephropathy by modulating the nuclear translocation of NF-kappaB (show NFKB1 Antibodies) and the expression of its downstream inflammatory factors in renal tubular epithelial cells
Cofilin-1 and transgelin (show TAGLN Antibodies) may play roles in the carcinogenesis and development of esophageal squamous cell carcinoma
results demonstrate that in VSMCs mechanical stimulation activates cofilin by a Nox4 (show NOX4 Antibodies)-dependent mechanism and that this pathway is required for cytoskeleton reorganization and cell reorientation
Cor1B, Cof1 and AIP1 work in concert through a temporally ordered pathway to induce highly efficient severing and disassembly of actin filaments.
the results of the present study suggested that miR (show MLXIP Antibodies)-429 inhibits the migration and invasion of colon cancer cells, partly at least, by mediating the expression of PAK6 (show PAK6 Antibodies), as well as the activity of cofilin signaling
These results indicated that cofilin might be involved in the modulation of Aspergillus fumigatus internalization into type II alveolar epithelial cells through the RhoA (show RHOA Antibodies)-ROCK-LIM (show PDLIM5 Antibodies) kinase pathway.
Myosin phosphatase and cofilin mediate cAMP/cAMP-dependent protein kinase-induced decline in endothelial cell isometric tension and myosin II regulatory light chain phosphorylation
Cyclic compression for 10 min up-regulated gene expression for the actin depolymerising proteins, cofilin and destrin (show DSTN Antibodies).
aberrant cofilin phosphorylation that induces actin polymerization might be a consequence of actin disassembly induced by the absence of Rac1.
novel roles for actin-depolymerizing factor (show DSTN Antibodies) and cofilin-1 in regulating the remodeling and permeability of epithelial junctions
reelin (show RELN Antibodies) and cofilin cooperate in controlling cytoskeletal dynamics during neuronal migration.
The data of this study identify overlapping functions for ADF (show TXN Antibodies) and n-cofilin in presynaptic physiology and vesicle in mice. trafficking.
Actin depolymerizing factor/cofilin double mutant mice exhibited hyperlocomotion, impulsivity, and impaired working memory. Hyperlocomotion and impulsive behavior were reversed by methylphenidate.
On the basal side of the neural plate, loss of CFL1 has the opposite effect on myosin: excess F-actin and myosin accumulate and the ectopic myosin light chain is phosphorylated.
LIMK1 (show LIMK1 Antibodies) and Cofilin phosphorylation depends on PKA and is essential for mouse sperm acrosomal exocytosis
prion protein is a co-receptor mediating neuronal cofilin-actin rod formation induced by beta-amyloid and proinflammatory cytokines
The principal role of cofilin in lamellipodia at steady state is to break down F-actin, control filament turnover, and regulate the rate of retrograde flow.
Subsequent analysis by MALDI-MS identified cofilin as one of the most prominently upregulated cytoskeletal protein (show ADD3 Antibodies) in pulmonary hypertension
In vitro, formation of cofilin oligomers was drastically reduced after phosphorylation by LIMK2 (show LIMK2 Antibodies).
glucose increases p-cofilin by phosphorylating LIMK1 through activation of Rho/Rho kinase, probably due to diacylglycerol-sensitive PKC activation resulting from increased glucose influx
Cofilin is necessary for maintaining the osmotic responsiveness of the cytoskeleton in tubular cells, and the Rho/ROCK/LIMK-mediated cofilin phosphorylation is a key mechanism in the hyperosmotic stress-induced F-actin increase.
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.
, non-muscle cofilin 1
, cofilin 1 (non-muscle)
, Cofilin/actin depolymerizing factor-like
, actin-depolymerizing factor
, no terminal filament
, twin star
, 18 kDa phosphoprotein
, cofilin, non-muscle isoform