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The protein encoded by CFL1 can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Additionally we are shipping Cofilin 1 (Non-Muscle) Kits (47) and Cofilin 1 (Non-Muscle) Proteins (24) and many more products for this protein.
Showing 10 out of 317 products:
Human Monoclonal CFL1 Primary Antibody for IF, WB - ABIN394735
Garg, Verma, Cook, Soofi, Venkatareddy, George, Mizuno, Gurniak, Witke, Holzman: Actin-depolymerizing factor cofilin-1 is necessary in maintaining mature podocyte architecture. in The Journal of biological chemistry 2010
Show all 5 references for ABIN394735
Dog (Canine) Monoclonal CFL1 Primary Antibody for IF, WB - ABIN968754
Chan, Bailly, Zebda, Segall, Condeelis: Role of cofilin in epidermal growth factor-stimulated actin polymerization and lamellipod protrusion. in The Journal of cell biology 2000
Show all 3 references for ABIN968754
Human Polyclonal CFL1 Primary Antibody for IHC (p), WB - ABIN197372
Kobayashi, Nishita, Mishima, Ohashi, Mizuno: MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration. in The EMBO journal 2006
Show all 3 references for ABIN197372
Human Polyclonal CFL1 Primary Antibody for DB - ABIN650888
Klemke, Kramer, Konstandin, Wabnitz, Samstag: An MEK-cofilin signalling module controls migration of human T cells in 3D but not 2D environments. in The EMBO journal 2010
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Human Monoclonal CFL1 Primary Antibody for EIA, IHC (p) - ABIN336102
Mannherz, Ballweber, Galla, Villard, Granier, Steegborn, Schmidtmann, Jaquet, Pope, Weeds: Mapping the ADF/cofilin binding site on monomeric actin by competitive cross-linking and peptide array: evidence for a second binding site on monomeric actin. in Journal of molecular biology 2007
Show all 2 references for ABIN336102
Human Polyclonal CFL1 Primary Antibody for IF, IHC (p) - ABIN319381
Chen, Cizeau, Vande Velde, Park, Bozek, Bolton, Shi, Dubik, Greenberg: Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. in The Journal of biological chemistry 1999
Show all 2 references for ABIN319381
Human Polyclonal CFL1 Primary Antibody for ELISA, WB - ABIN1534356
Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. in Cell 2006
Human Polyclonal CFL1 Primary Antibody for FACS, WB - ABIN650759
Fazal, Bijli, Minhajuddin, Rein, Finkelstein, Rahman: Essential role of cofilin-1 in regulating thrombin-induced RelA/p65 nuclear translocation and intercellular adhesion molecule 1 (ICAM-1) expression in endothelial cells. in The Journal of biological chemistry 2009
Results suggest that elevation of actin dynamics by Xenopus ADF/cofilin (XAC) activation through Slingshot phosphatase (XSSH) phosphorylation is required for meiotic spindle assembly.
Gastrulation movement requires ADF/cofilin activity through dynamic regulation of its phosphorylation state.
proper actin turnover mediated by Cfl1 is essential for adhesion between the deep cell layer and the enveloping layer and cell movements during gastrulation in zebrafish
Silencing of cofilin-1 led to an Accumulation of F-actin fibers and significantly decreased podocyte migration. ability
Cofilin/Twinstar phosphorylation levels increase in response to impaired coenzyme a metabolism.
AIP1 enhances cofilin-mediated actin disassembly in the apical region of precluster cells to promote remodeling of adherense junctions.
Data show that cofilin is required for F-actin turnover and lamellipodial protrusion in the border cells.
tsr is required for planar cell polarity patterning.
These results indicate that changes in the extent of cofilin phosphorylation are regulated by Ssh in response to changes in the levels and/or organisation of F-actin.
Results show that twinstar (tsr), which encodes Drosophila cofilin/ADF (actin-depolymerizing factor), is required for elongation of the retinal cell body and the morphogenesis of the rhabdomere.
These findings indicate that inhibition of the Rac1WAVE2Arp2/3 signaling pathway may promote radiosensitivity, which may partially result from the downregulation of CFL1 (show VPS72 Antibodies) in U251 human glioma cells.
The present findings demonstrated that the anticancer effect of docetaxel induces the apoptosis of prostate cancer via the suppression of the cofilin1 and paxillin (show PXN Antibodies) signaling pathways, which will assist in setting a stage for the clinical treatment of prostate cancer.
VEGFA (show VEGFA Antibodies) induced phosphorylation of Pak1 (show PAK1 Antibodies) and its effector cofilin in a manner that was dependent on time as well as p38MAPKbeta.
CFL1 (show VPS72 Antibodies) itself does not translocate actin into the cell nucleus but this transport requires the functional expression of IPO9 (show IPO9 Antibodies).
Abnormal CFL1 (show VPS72 Antibodies) expression may affect vulvar carcinogenesis and subsequent progression.
PAK1 (show PAK1 Antibodies)-cofilin phosphorylation mechanism to mediate lung adenocarcinoma cells migration promoted by apelin (show APLN Antibodies)-13
Progesterone (P4) increases human astrocytoma cells migration and invasion through its intracellular receptor, and that cofilin activation by P4 is independent of progesterone receptor (show PGR Antibodies) action.
the presence of the actin-severing protein, cofilin, in human sperm, is reported.
Aurora kinase A (show AURKA Antibodies) has a role in inducing papillary thyroid cancer lymph node metastasis by promoting cofilin-1 activity
analysis of human Cof1, Cof2, and ADF effects on actin filament severing and turnover
Myosin phosphatase and cofilin mediate cAMP/cAMP-dependent protein kinase-induced decline in endothelial cell isometric tension and myosin II regulatory light chain phosphorylation
Cyclic compression for 10 min up-regulated gene expression for the actin depolymerising proteins, cofilin and destrin (show DSTN Antibodies).
Data show that the primary effect of costimulation blockade was to decrease recruitment of the activator of actin nucleation WAVE2 (Wiskott-Aldrich syndrome protein family member protein 2) and cofilin (actin-severing protein) to F-actin.
These results strongly support the active role of cofilin in ischemia-induced neuronal degeneration and apoptosis.
Caspase-11 (show CASP4 Antibodies) targets cofilin via the RhoA GTPase, whereas caspase-1 (show CASP1 Antibodies) engages the Slingshot phosphatase
aberrant cofilin phosphorylation that induces actin polymerization might be a consequence of actin disassembly induced by the absence of Rac1.
novel roles for actin-depolymerizing factor (show DSTN Antibodies) and cofilin-1 in regulating the remodeling and permeability of epithelial junctions
reelin (show RELN Antibodies) and cofilin cooperate in controlling cytoskeletal dynamics during neuronal migration.
The data of this study identify overlapping functions for ADF (show TXN Antibodies) and n-cofilin in presynaptic physiology and vesicle in mice. trafficking.
Actin depolymerizing factor/cofilin double mutant mice exhibited hyperlocomotion, impulsivity, and impaired working memory. Hyperlocomotion and impulsive behavior were reversed by methylphenidate.
On the basal side of the neural plate, loss of CFL1 has the opposite effect on myosin: excess F-actin and myosin accumulate and the ectopic myosin light chain is phosphorylated.
In vitro, formation of cofilin oligomers was drastically reduced after phosphorylation by LIMK2 (show LIMK2 Antibodies).
glucose increases p-cofilin by phosphorylating LIMK1 through activation of Rho/Rho kinase, probably due to diacylglycerol-sensitive PKC activation resulting from increased glucose influx
Cofilin is necessary for maintaining the osmotic responsiveness of the cytoskeleton in tubular cells, and the Rho/ROCK/LIMK-mediated cofilin phosphorylation is a key mechanism in the hyperosmotic stress-induced F-actin increase.
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.
, non-muscle cofilin 1
, cofilin 1 (non-muscle)
, Cofilin/actin depolymerizing factor-like
, actin-depolymerizing factor
, no terminal filament
, twin star
, 18 kDa phosphoprotein
, cofilin, non-muscle isoform