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Cofilin 1 (Non-Muscle) Proteins (CFL1)

The protein encoded by CFL1 can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Additionally we are shipping Cofilin 1 (Non-Muscle) Antibodies (308) and Cofilin 1 (Non-Muscle) Kits (58) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CFL1 1072 P23528
CFL1 12631 P18760
CFL1 29271 P45592
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Top Cofilin 1 (Non-Muscle) Proteins at antibodies-online.com

Showing 10 out of 24 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$407.00
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HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$739.20
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,377.83
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Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$2,377.83
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Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,377.83
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,377.83
Details

CFL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

Rat (Rattus) ,

Top referenced Cofilin 1 (Non-Muscle) Proteins

  1. Human CFL1 Protein expressed in Escherichia coli (E. coli) - ABIN666701 : Mannherz, Ballweber, Galla, Villard, Granier, Steegborn, Schmidtmann, Jaquet, Pope, Weeds: Mapping the ADF/cofilin binding site on monomeric actin by competitive cross-linking and peptide array: evidence for a second binding site on monomeric actin. in Journal of molecular biology 2007 (PubMed)
    Show all 3 references for ABIN666701

  2. Human CFL1 Protein expressed in Escherichia coli (E. coli) - ABIN2006220 : Ichetovkin, Han, Pang, Knecht, Condeelis: Actin filaments are severed by both native and recombinant dictyostelium cofilin but to different extents. in Cell motility and the cytoskeleton 2000 (PubMed)

More Proteins for Cofilin 1 (Non-Muscle) (CFL1) Interaction Partners

Xenopus laevis Cofilin 1 (Non-Muscle) (CFL1) interaction partners

  1. Results suggest that elevation of actin dynamics by Xenopus ADF/cofilin (XAC) activation through Slingshot phosphatase (XSSH) phosphorylation is required for meiotic spindle assembly.

  2. Gastrulation movement requires ADF/cofilin activity through dynamic regulation of its phosphorylation state.

Zebrafish Cofilin 1 (Non-Muscle) (CFL1) interaction partners

  1. proper actin turnover mediated by Cfl1 is essential for adhesion between the deep cell layer and the enveloping layer and cell movements during gastrulation in zebrafish

  2. Silencing of cofilin-1 led to an Accumulation of F-actin fibers and significantly decreased podocyte migration. ability

Fruit Fly (Drosophila melanogaster) Cofilin 1 (Non-Muscle) (CFL1) interaction partners

  1. Cofilin/Twinstar phosphorylation levels increase in response to impaired coenzyme a metabolism.

  2. AIP1 enhances cofilin-mediated actin disassembly in the apical region of precluster cells to promote remodeling of adherense junctions.

  3. Data show that cofilin is required for F-actin turnover and lamellipodial protrusion in the border cells.

  4. tsr is required for planar cell polarity patterning.

  5. These results indicate that changes in the extent of cofilin phosphorylation are regulated by Ssh in response to changes in the levels and/or organisation of F-actin.

  6. Results show that twinstar (tsr), which encodes Drosophila cofilin/ADF (actin-depolymerizing factor), is required for elongation of the retinal cell body and the morphogenesis of the rhabdomere.

Human Cofilin 1 (Non-Muscle) (CFL1) interaction partners

  1. Progesterone (P4) increases human astrocytoma cells migration and invasion through its intracellular receptor, and that cofilin activation by P4 is independent of progesterone receptor (show PGR Proteins) action.

  2. the presence of the actin-severing protein, cofilin, in human sperm, is reported.

  3. Aurora kinase A (show AURKA Proteins) has a role in inducing papillary thyroid cancer lymph node metastasis by promoting cofilin-1 activity

  4. analysis of human Cof1, Cof2, and ADF effects on actin filament severing and turnover

  5. Cofilin 1 activation prevents the defects in axon elongation and guidance induced by extracellular alpha-synuclein

  6. novel roles for actin-depolymerizing factor (show GSN Proteins) and cofilin-1 in regulating the remodeling and permeability of epithelial junctions

  7. cofilin1 is involved in hypertensive nephropathy by modulating the nuclear translocation of NF-kappaB (show NFKB1 Proteins) and the expression of its downstream inflammatory factors in renal tubular epithelial cells

  8. Cofilin-1 and transgelin (show TAGLN Proteins) may play roles in the carcinogenesis and development of esophageal squamous cell carcinoma

  9. results demonstrate that in VSMCs mechanical stimulation activates cofilin by a Nox4 (show NOX4 Proteins)-dependent mechanism and that this pathway is required for cytoskeleton reorganization and cell reorientation

  10. Cor1B, Cof1 and AIP1 work in concert through a temporally ordered pathway to induce highly efficient severing and disassembly of actin filaments.

Cow (Bovine) Cofilin 1 (Non-Muscle) (CFL1) interaction partners

  1. Myosin phosphatase and cofilin mediate cAMP/cAMP-dependent protein kinase-induced decline in endothelial cell isometric tension and myosin II regulatory light chain phosphorylation

  2. Cyclic compression for 10 min up-regulated gene expression for the actin depolymerising proteins, cofilin and destrin (show DSTN Proteins).

Mouse (Murine) Cofilin 1 (Non-Muscle) (CFL1) interaction partners

  1. Caspase-11 (show CASP4 Proteins) targets cofilin via the RhoA GTPase, whereas caspase-1 (show CASP1 Proteins) engages the Slingshot phosphatase

  2. aberrant cofilin phosphorylation that induces actin polymerization might be a consequence of actin disassembly induced by the absence of Rac1.

  3. novel roles for actin-depolymerizing factor (show DSTN Proteins) and cofilin-1 in regulating the remodeling and permeability of epithelial junctions

  4. reelin (show RELN Proteins) and cofilin cooperate in controlling cytoskeletal dynamics during neuronal migration.

  5. The data of this study identify overlapping functions for ADF (show TXN Proteins) and n-cofilin in presynaptic physiology and vesicle in mice. trafficking.

  6. Actin depolymerizing factor/cofilin double mutant mice exhibited hyperlocomotion, impulsivity, and impaired working memory. Hyperlocomotion and impulsive behavior were reversed by methylphenidate.

  7. On the basal side of the neural plate, loss of CFL1 has the opposite effect on myosin: excess F-actin and myosin accumulate and the ectopic myosin light chain is phosphorylated.

  8. LIMK1 (show LIMK1 Proteins) and Cofilin phosphorylation depends on PKA and is essential for mouse sperm acrosomal exocytosis

  9. prion protein is a co-receptor mediating neuronal cofilin-actin rod formation induced by beta-amyloid and proinflammatory cytokines

  10. The principal role of cofilin in lamellipodia at steady state is to break down F-actin, control filament turnover, and regulate the rate of retrograde flow.

Pig (Porcine) Cofilin 1 (Non-Muscle) (CFL1) interaction partners

  1. In vitro, formation of cofilin oligomers was drastically reduced after phosphorylation by LIMK2 (show LIMK2 Proteins).

  2. glucose increases p-cofilin by phosphorylating LIMK1 through activation of Rho/Rho kinase, probably due to diacylglycerol-sensitive PKC activation resulting from increased glucose influx

  3. Cofilin is necessary for maintaining the osmotic responsiveness of the cytoskeleton in tubular cells, and the Rho/ROCK/LIMK-mediated cofilin phosphorylation is a key mechanism in the hyperosmotic stress-induced F-actin increase.

Cofilin 1 (Non-Muscle) (CFL1) Protein Profile

Protein Summary

The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.

Gene names and symbols associated with Cofilin 1 (Non-Muscle) Proteins (CFL1)

  • cofilin 1 (non-muscle) (cfl1-a)
  • cofilin 1 (non-muscle) (cfl1)
  • cofilin 1 (non-muscle) (CFL1)
  • twinstar (tsr)
  • Cof1p (COF1)
  • cofilin (TSTA_042790)
  • cofilin 1 (non-muscle) (Cfl1)
  • cofilin 1 (non-muscle)-like (LOC100341589)
  • cofilin 1, non-muscle (Cfl1)
  • COFILIN protein (COFILIN)
  • Contrafreeloading (CFL)
  • 12/8 protein
  • AA959946 protein
  • Adf protein
  • ADF/cofilin protein
  • Cadf protein
  • cb86 protein
  • CFL protein
  • CFL1 protein
  • CG4254 protein
  • Cof protein
  • cofilin protein
  • cofilin/actin depolymerizing factor homolog protein
  • cofilin/ADF protein
  • D-cof protein
  • D61 protein
  • Dmel\\CG4254 protein
  • l(2)03101 protein
  • l(2)k03101 protein
  • l(2)k05633 protein
  • l(2)k13409 protein
  • ntf protein
  • sb:cb86 protein
  • T8 protein
  • Tsr protein
  • wu:fb18a04 protein
  • wu:fk77b03 protein
  • xac1 protein
  • xac2 protein
  • zgc:56501 protein

Protein level used designations for Cofilin 1 (Non-Muscle) Proteins (CFL1)

ADF/cofilin-1 , cofilin-1-A , ADF/cofilin , cofilin-1 , non-muscle cofilin 1 , cofilin 1 (non-muscle) , ADFcofilin , CG4254-PA , Cofilin/actin depolymerizing factor-like , DCofilin , actin-depolymerizing factor , cofilin , no terminal filament , tsr-PA , twin star , Cof1p , 18 kDa phosphoprotein , cofilin, non-muscle isoform , p18

GENE ID SPECIES
379258 Xenopus laevis
407855 Xenopus (Silurana) tropicalis
406738 Danio rerio
745772 Pan troglodytes
37841 Drosophila melanogaster
850676 Saccharomyces cerevisiae S288c
8104756 Talaromyces stipitatus ATCC 10500
1072 Homo sapiens
476022 Canis lupus familiaris
534553 Bos taurus
100732287 Cavia porcellus
494432 Ovis aries
100341589 Oryctolagus cuniculus
12631 Mus musculus
29271 Rattus norvegicus
445532 Sus scrofa
100309654 Gallus gallus
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