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Complement Factor H-Related 5 Proteins (CFHR5)

CFHR5 is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Additionally we are shipping Complement Factor H-Related 5 Antibodies (28) and Complement Factor H-Related 5 Kits (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CFHR5 81494 Q9BXR6
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Top Complement Factor H-Related 5 Proteins at

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
HOST_HEK-293 Cells Human His tag   50 μg Log in to see 5 Days
HOST_Human Human Un-conjugated   10 μg Log in to see 11 to 14 Days

CFHR5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,

More Proteins for Complement Factor H-Related 5 (CFHR5) Interaction Partners

Human Complement Factor H-Related 5 (CFHR5) interaction partners

  1. Next-generation sequencing of the CFH (show CFH Proteins) region identified putatively functional variants (missense, splice site and indel) on the four common haplotypes. We found no expression of any of the five CFH (show CFH Proteins)-related genes in the retina or RPE (show RPE Proteins)/Choroid/Sclera, in contrast to the liver, which is the main source of the circulating proteins. [CFHR5]

  2. Studies indicate that complement factor H (show CFH Proteins)-related proteins (FHR1 (show CFHR1 Proteins)-5) may enhance complement activation, with important implications for the role of these proteins in disease.

  3. In this study, we identify pentraxin 3 (PTX3 (show PTX3 Proteins)) as a novel ligand of CFHR5

  4. At least two distinct intronic breakpoints within the CFHR5 gene can cause the same mutant CFHR5 protein and C3 glomerulopathy.

  5. A hybrid CFHR2 (show CFHR2 Proteins)-CFHR5 plasma protein, arising from a chromosomal deletion mutation stabilizes the C3 convertase and reduces factor H (show CFH Proteins)-mediated convertase decay.

  6. Recent investigations in London and Cyprus culminated in the identification of another autosomal dominant condition that presents with microscopic haematuria because of heterozygous mutations in the CFHR5 gene--{review}

  7. A potentially pathogenic sequence variation was found in CFHR5 in the patients with atypical hemolytic uremic syndrome.

  8. CFHR5 nephropathy is discussed.

  9. Describe the clinical course, significant variable expressivity, and marked gender difference regarding the development of chronic renal failure in familial C3 glomerulopathy associated with CFHR5 mutations.

  10. evidence for an inherited renal disease, endemic in Cyprus, characterised by microscopic and synpharyngitic macroscopic haematuria, renal failure and C3 glomerulonephritis; affected individuals have an internal duplication within the gene for CFHR5

Complement Factor H-Related 5 (CFHR5) Protein Profile

Protein Summary

This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS).

Gene names and symbols associated with CFHR5

  • complement factor H-related 5 (CFHR5)
  • CFHL5 protein
  • CFHR5D protein
  • FHR-5 protein
  • FHR5 protein

Protein level used designations for CFHR5

complement factor H-related protein 5 , factor H-related protein 5

81494 Homo sapiens
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